promonocytic

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HIV-1 promonocytic and lymphoid cell lines: an in vitro model of in vivo mitochondrial and apoptotic lesion.

Morén C1,2, González-Casacuberta I1,2, Álvarez-Fernández C3, Bañó M1,2, Catalán-Garcia M1,2, Guitart-Mampel M1,2, Juárez-Flores DL1,2, Tobías E1,2, Milisenda J1,2, Cardellach F1,2, Gatell JM3, Sánchez-Palomino S3, Garrabou G1,2.
Journal of cellular and molecular medicine.J Cell Mol Med.2017 Feb;21(2):402-409. doi: 10.1111/jcmm.12985. Epub 2016 Oct 18.
To characterize mitochondrial/apoptotic parameters in chronically human immunodeficiency virus (HIV-1)-infected promonocytic and lymphoid cells which could be further used as therapeutic targets to test pro-mitochondrial or anti-apoptotic strategies as in vitro cell platforms to deal with HIV-infect
PMID 27758070

Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNFα in human phagocytes.

M M Y1,2, O Yu K2,3, L I S3, O Yu A2, A V S4, M B E5,6, M G V2.
Cell stress & chaperones.Cell Stress Chaperones.2017 Jan;22(1):163-171. doi: 10.1007/s12192-016-0743-z. Epub 2016 Oct 26.
Human heat shock protein Hsp70 was experimentally inserted into polyelectrolyte microcapsules. Encapsulated recombinant Hsp70 was studied in terms of its effects on neutrophil apoptosis, the production of reactive oxygen species, and the secretion of tumor necrosis factor alpha by promonocytic THP-1
PMID 27783274

Selected polyphenols potentiate the apoptotic efficacy of glycolytic inhibitors in human acute myeloid leukemia cell lines. Regulation by protein kinase activities.

de Blas E1, Estañ MC2, Del Carmen Gómez de Frutos M3, Ramos J4, Del Carmen Boyano-Adánez M5, Aller P1.
Cancer cell international.Cancer Cell Int.2016 Sep 7;16(1):70. doi: 10.1186/s12935-016-0345-y. eCollection 2016.
BACKGROUND: The glycolysis inhibitor 2-deoxy-d-glucose (2-DG) is a safe, potentially useful anti-tumour drug, but its efficacy is normally low when used alone. Recent studies indicated that 2-DG stimulates the PI3K/Akt and MEK/ERK defensive pathways, which limits the apoptotic efficacy in tumour cel
PMID 27610044