プログルメタシン
- 関
- proglumetacin maleate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/05 00:46:09」(JST)
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Proglumetacin
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Systematic (IUPAC) name |
3-{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl N2-benzoyl-N,N-dipropyl-α-glutaminate
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pharmacokinetic data |
Metabolism |
Hepatic. Undergoes enterohepatic recirculation |
Identifiers |
CAS Number |
57132-53-3 59209-40-4 |
ATC code |
M01AB14 |
PubChem |
CID 4921 |
ChemSpider |
4752 Y |
UNII |
FV919079LU Y |
ChEBI |
CHEBI:76263 |
Synonyms |
3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate |
Chemical data |
Formula |
C46H58ClN5O8 |
Molar mass |
844.43442 g/mol |
SMILES
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Clc1ccc(cc1)C(=O)n3c2ccc(OC)cc2c(c3C)CC(=O)OCCN4CCN(CC4)CCCOC(=O)CCC(C(=O)N(CCC)CCC)NC(=O)c5ccccc5
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InChI
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InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55) Y
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Key:PTXGHCGBYMQQIG-UHFFFAOYSA-N Y
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(verify) |
Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.
References
- ^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267.
Prostanoid signaling
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Receptor
(ligands) |
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Enzyme
(inhibitors) |
COX (PTGS) |
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PGD2 synthase |
- Retinoids
- Selenium (selenium tetrachloride, sodium selenite, selenium disulfide)
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PGE synthase |
HQL-79
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PGF synthase |
Bimatoprost
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PGI2 synthase |
Tranylcypromine
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TXA synthase |
- Camonagrel
- Dazmegrel
- Dazoxiben
- Furegrelate
- Isbogrel
- Midazogrel
- Nafagrel
- Nicogrelate
- Ozagrel
- Picotamide
- Pirmagrel
- Ridogrel
- Rolafagrel
- Samixogrel
- Terbogrel
- U63557A
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Others |
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- Prostaglandin G2
- Prostaglandin H2
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See also: Leukotrienergics
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English Journal
- [Sports-induced acute epicondylitis of the elbow and conservative therapy].
- Förster KK, Schmid K, Reichelt A.SourceAbt. Klinische Forschung, Opfermann Arzneimittel GmbH, Wiehl Orthop. Universitätsklinik, Freiburg.
- Sportverletzung Sportschaden : Organ der Gesellschaft für Orthopädisch-Traumatologische Sportmedizin.Sportverletz Sportschaden.1997 Mar;11(1):16-20.
- 48 patients with an acute lateral and/or medial epicondylitis of the elbow, induced by sporting activities, were treated in a prospective, controlled, double-blind, and randomised clinical study over a period of one to two weeks in a standard manner, either with taping and the oral NSAID proglumetac
- PMID 9213940
- Deleuse L.
- Revue médicale de Bruxelles.Rev Med Brux.1993 Oct;14(8):262.
- PMID 8272684
- Possible mechanisms of gastroduodenal mucosal damage in volunteers treated with nonsteroidal antiinflammatory drugs--the usefulness of prodrugs.
- Yanagawa A, Fukumura T, Matsui H, Uemura H, Endo T, Nakagawa T, Mizushima Y.SourceInstitute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan.
- The Journal of rheumatology.J Rheumatol.1992 Jul;19(7):1075-82.
- A controlled double blind study on the incidence of nonsteroidal antiinflammatory drug (NSAID) gastropathy was performed in 29 healthy volunteers administered diclofenac Na (10 subjects) or a prodrug (loxoprofen Na in 10 subjects and proglumetacin maleate in 9 subjects). The incidence of NSAID gastr
- PMID 1512761
Japanese Journal
- 疼痛克服とDDS : 経口麻薬性鎮痛薬·非ステロイド性抗炎症薬の進歩
- 佐伯 茂
- Drug Delivery System 20(5), 521-529, 2005
- 徐放性麻薬性鎮痛薬には, 主成分がモルヒネであるMSコンチン, MSツワイスロン, モルペス細粒, カディアン, ピーガード錠などがある. 前3者は1日2回の内服, 後2者は1日1回の内服ですむ, 一方, アヘンから抽出されるテバインを原料に合成された麻薬:オキシコドンの徐放性製剤としてオキシコンチンがある. この薬物は1日2回の内服ですむ. これらの徐放性製剤は, がん性疼痛にのみ適応が認められ …
- NAID 130000747974
- マレイン酸プログルメタシンの結晶多形が溶出特性および血中動態に及ぼす影響
- 安友 照人,白井 悟,佐藤 利治,矢田 いく代,松田 芳久,大塚 誠
- 薬剤学 = The archives of practical pharmacy 61(3), 97-108, 2001-09-20
- NAID 10007945422
Related Links
- InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9- 12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38- 33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9 ...
Related Pictures
★リンクテーブル★
[★]
- 英
- proglumetacin、proglumetacin maleate
- 関
- マレイン酸プログルメタシン
[★]
- 関
- proglumetacin