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1. 大腸癌の分子遺伝学molecular genetics of colorectal cancer [show details]
…have lost the second APC allele (through deletion or somatic mutation), suggesting that loss of APC expression is a very early event in CRC tumorigenesis . The function of the APC gene product and the …
2. 消化管出血のマネージメントにおけるアルゴンプラズマ凝固法argon plasma coagulation in the management of gastrointestinal hemorrhage [show details]
…short bursts of APC are delivered. Specifically, the following three modes are available on the current VIO 300D/APC 2 system: Forced APC is the original continuous delivery mode. Pulsed APC fires intermittently …
3. 家族性腺腫性ポリポーシス：患者および家族のスクリーニングおよびマネージメントfamilial adenomatous polyposis screening and management of patients and families [show details]
…lifelong in Adenomatous Polyposis Coli (APC) mutation carriers. However, in first-degree relatives of affected individuals from families without an identified pathogenic APC mutation, intensive screening can …
4. 癌免疫療法の原則principles of cancer immunotherapy [show details]
…B7-1 and B7-2 (CD80/86) on the APC This costimulatory process is tightly regulated by both "agonist" molecules (eg, GITR, OX40, ICOS) and inhibitory signals on both the APC and T cells, often collectively …
5. デスモイド腫瘍：疫学、危険因子、分子学的病因、臨床症状、診断、および局所療法desmoid tumors epidemiology risk factors molecular pathogenesis clinical presentation diagnosis and local therapy [show details]
…Desmoids in familial adenomatous polyposis (FAP) arise from APC inactivation and subsequent accumulation of beta-catenin in cells . In contrast, APC mutations are uncommon in sporadic desmoids, which usually …

English Journal

Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism.

Blaszczak AM, Wright VP, Anandani K, Liu J, Jalilvand A, Bergin S, Nicoloro SM, Czech MP, Lafuse W, Deng T, Bradley D, Hsueh WA.
Journal of immunology (Baltimore, Md. : 1950). 2019 Apr;202(8)2451-2459.
Macrophages, B cells, and adipocytes are among the adipose tissue (AT) APCs that differentiate and activate naive CD4 T cells. Mice with adipocyte loss of MHC class II (MHC II) are more insulin sensitive. Because macrophages are professional APCs, mice with genetic myeloid MHC II depletion (myeloid
PMID 30850480

"Tweet"-format reflective writing: A hidden needs assessment?

Dressler JA, Ryder BA, Monteiro K, Cheschi E, Connolly M, Miner TJ, Harrington DT.
American journal of surgery. 2019 Feb;217(2)314-317.
Medical student reflection is integral for professional development. Preliminary findings suggest that short-format writing promotes reflection and identifies impactful experiences. We sought to determine whether reflective writing could be used as a clerkship needs assessment. During their surgical
PMID 30301518

Mechanism of Lycium barbarum polysaccharides liposomes on activating murine dendritic cells.

Bo R, Liu Z, Zhang J, Gu P, Ou N, Sun Y, Hu Y, Liu J, Wang D.
Carbohydrate polymers. 2019 Feb;205()540-549.
Dendritic cells (DCs) are professional antigen-presenting cells (APC) that play a central role in the initiation and regulation of immune responses. We have previously demonstrated that Lycium barbarum polysaccharides liposomes (LBPL) as immune adjuvant elicits strong antigen-specific Th1 immune res
PMID 30446138

Japanese Journal

小規模可搬APCの開発と東日本大震災における臨時災害放送局への導入(放送技術・番組制作技術,および一般)

伊藤正史,天谷啓介
映像情報メディア学会技術報告 36.23(0), 1-4, 2012
… 基づく臨時災害放送局が開局した.2011年末,その一つである「女川さいがいエフエム」の天谷は,在京局の局員として番組送出システムの設計に携わっていた伊藤の技術報告を読み,臨時災害放送局にも使える小型APCはないかとの相談をSNSで持ちかけた.現在,伊藤は送出部門の所属ではないが,任意団体において既存の大規模送出システムとは対照的な小型汎用送出システムの研究開発を続けており,放送技術者の社会的責任と …
NAID 110009480498

Characterization of Monocyte-Derived Dendritic Cells from Cats Infected with Feline Immunodeficiency Virus

Mizukoshi Fuminori,Baba Kenji,Horiuchi Hiroshi [他],GOTO-KOSHINO Yuko,SETOGUCHI-MUKAI Asuka,FUJINO Yasuhito,OHNO Koichi,MOORE Peter F,TSUJIMOTO Hajime
Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 71(7), 865-871, 2009
… Dendritic cells (DCs) are professional antigen presenting cells (APCs) that possess an extraordinary capacity to stimulate naïve T cells and initiate a primary immune response. … Monocyte-derived DCs from FIV-infected cats as well as those from healthy controls showed a dendritic appearance and expressed an APC-like phenotype (CD1c<sup>+</sup>, CD80<sup>+</sup> …
NAID 130000134420

肝類洞内皮細胞のＴ細胞抑制機構による移植免疫制御

大段秀樹
日本臨床免疫学会総会抄録集 36(0), 37-37, 2008
… 臓器移植後の拒絶機構には、レシピエントのT細胞が移植臓器内のドナー由来抗原提示細胞antigen-presenting cell (APC)から主要組織適合性抗原(MHC)を直接認識する経路とレシピエント自身のAPCから移植片由来のドナー抗原を間接認識する経路がある。 …
NAID 130006949055