プリマキン貧血
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- 1. 旅行者におけるマラリア感染の予防prevention of malaria infection in travelers [show details]
… daily for seven days following exposure. Dosing is outlined in the tables . Primaquine can cause hemolytic anemia in those with G6PD deficiency. Therefore, a G6PD level must be determined prior to …
- 2. 抗マラリア剤：概要antimalarial drugs an overview [show details]
…eliminating dormant hypnozoites. Primaquine also has activity against the preerythrocytic stage and gametocytes of P. falciparum . Primaquine can cause hemolytic anemia in those with glucose-6-phosphate …
- 3. 大赤血球症/大球性貧血macrocytosis macrocytic anemia [show details]
… topic discusses causes of macrocytosis and macrocytic anemia. Additional topics discuss the following: Microcytosis/microcytic anemia – General anemia evaluation; Child – Adult – Vitamin B12 and folate …
- 4. グルコース-6-リン酸脱水素酵素（G6PD）欠損症の診断とマネージメントdiagnosis and management of glucose 6 phosphate dehydrogenase g6pd deficiency [show details]
… hemolytic anemia. Pathophysiology and genetics of G6PD deficiency – Diagnostic approach to the child with hemolytic anemia – Diagnostic approach to the adult with hemolytic anemia – G6PD… primaquine, quinine, rasburicase, and others. A common example is a patient who requires presumptive anti-relapse therapy with primaquine to eradicate the…
- 5. マラリアにおける貧血anemia in malaria [show details]
… Treatment of anemia in malaria is discussed further separately. There are two situations where anemia may be a complication of therapy. First, there is the well-recognized risk that primaquine used to treat …
English Journal
- The impact of using primaquine without prior G6PD testing: a case series describing the obstacles to the medical management of haemolysis.
- Chu CS, Bancone G, Soe NL, Carrara VI, Gornsawun G, Nosten F.
- Wellcome open research. 2019 ;4()25.
- Radical cure of malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. This is the only recommended regimen for this patient sub-group. If national malaria programs mandate daily primaquine dosing (the recommended regimen for G6PD normal individu
- PMID 31069260
- The tolerability of single low dose primaquine in glucose-6-phosphate deficient and normal falciparum-infected Cambodians.
- Dysoley L, Kim S, Lopes S, Khim N, Bjorges S, Top S, Huch C, Rekol H, Westercamp N, Fukuda MM, Hwang J, Roca-Feltrer A, Mukaka M, Menard D, Taylor WR.
- BMC infectious diseases. 2019 Mar;19(1)250.
- The WHO recommends single low-dose primaquine (SLDPQ, 0.25 mg/kg body weight) in falciparum-infected patients to block malaria transmission and contribute to eliminating multidrug resistant Plasmodium falciparum from the Greater Mekong Sub region (GMS). However, the anxiety regarding PQ-induced ac
- PMID 30871496
Japanese Journal
- Reactivity of Blood Samples Spotted onto Filter Papers in the WST-8 Method for Screening of G6PD Deficiency.
- Arai Meiji,Kosuge Kazuko,Kawamoto Fumihiko,Matasuoka Hiroyuki
- Acta Medica Okayama 60(2), 127-134, 2006-04
- … <p>Deficiency of glucose-6-phosphate dehydrogenase (G6PD) causes acute hemolytic anemia triggered by oxidative drugs such as primaquine. … It is therefore essential in malaria-endemic areas for malaria patients to be confirmed for their G6PD activity before taking primaquine. …
- NAID 120002305857
- グルコース-6-リン酸脱水素酵素異常症の迅速スクリーニング法の開発
- An Improved Single-step Screening Method for Glucose-6-Phosphate Dehydrogenase Deficiency.
- HIRONO AKIRA,FUJII HISAICHI,MIWA SHIRO
- 日本熱帯医学会雑誌 26(1), 1-4, 1998
- … Our method is particularly suitable for field detection of G6PD-deficient subjects prior to administration of primaquine <I>in situ</I>. …
- NAID 130003975951
Related Links
- 1. J Pharmacol Exp Ther. 2004 Apr;309(1):79-85. Epub 2004 Jan 14. Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine. Bowman ZS(1 ...
- Primaquine is used alone or with another medication to treat malaria (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death) and to prevent the disease from coming back in people that are ...
- It has been recognized for a long time that 8-aminoquinoline compounds may cause hemolytic anemia in certain individuals, but until recently the mechanism of such sensitivity has remained obscure. The use of modern ...
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- primaquine anemia
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- 抗マラリア薬