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- 1. 幼児および小児における低カルシウム血症の病因 etiology of hypocalcemia in infants and children
- 2. 成人における低カルシウム血症の原因 etiology of hypocalcemia in adults
- 3. 慢性腎臓病に伴う骨・ミネラル代謝異常（CKD-MBD）の概要 overview of chronic kidney disease mineral bone disease ckd mbd
English Journal
- Potential treatment of hypoparathyroidism with recombinant plasmids encoding preproparathyroid hormone.
- Liu D1, Zhu Y, Yang C, Long J, Yao C, Li J, Wang S.
- Journal of endocrinological investigation.J Endocrinol Invest.2012 May;35(5):479-84. doi: 10.3275/7966. Epub 2011 Sep 27.
- Hypoparathyroidism cannot be cured by oral or intravenous calcium supplements. Using molecular biology techniques to induce the production of PTH is an ideal option to treat hypoparathyroidism. In this study, we established a recombinant plasmid encoding a mutant preproPTH with a skeletal muscle cre
- PMID 21952560
- GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone.
- Thomée C1, Schubert SW, Parma J, Lê PQ, Hashemolhosseini S, Wegner M, Abramowicz MJ.
- The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2005 May;90(5):2487-92. Epub 2005 Feb 22.
- Isolated hypoparathyroidism is an uncommon metabolic disorder characterized by hypocalcemia and hyperphosphatemia, with absent or low levels of PTH. It may present as an apparently sporadic disorder or may be transmitted in families as a genetic trait. Mutations of the calcium-sensing receptor gene
- PMID 15728199
- The murine gene encoding parathyroid hormone: genomic organization, nucleotide sequence and transcriptional regulation.
- He B1, Tong TK, Hiou-Tim FF, Al-Akad B, Kronenberg HM, Karaplis AC.
- Journal of molecular endocrinology.J Mol Endocrinol.2002 Oct;29(2):193-203.
- The type 1 parathyroid hormone receptor (PTHR1) binds, with equal affinity, two ligands with distinct biological functions: PTH, the major peptide hormone controlling calcium homeostasis, and the paracrine factor, PTH-related peptide (PTHrP), a local regulator of cellular proliferation and different
- PMID 12370121
Japanese Journal
- Lack of Mutations of Preproparathyroid Hormone Gene in Three Kindreds with Familial Isolated Hypoparathyroidism
- YAMAMOTO TOSHIKAZU,YOSHIMASA YASUNAO,KOSHIYAMA HIROYUKI,SUGIYAMA KYOKO,OKIGAKI MITSUHIKO,YAMADA TAKAYUKI,ISHII HITOSHI,YAGURA TOSHIHIRO,FUJIMOTO KAZUMITSU,OHNISHI TOSHIAKI,KOH TOSHIKIYO,HINO MEGUMI,KURAHACHI HIROYUKI,YOSHIMASA TAKAAKI,NAKAO KAZUWA
- Endocrine journal 44(1), 175-180, 1997-02-01
- NAID 10016356658
- Lack of Mutations of Preproparathyroid Hormone Gene in Three Kindreds with Familial Isolated Hypoparathyroidism.
- YAMAMOTO TOSHIKAZU,OHNISHI TOSHIAKI,KOH TOSHIKIYO,HINO MEGUMI,KURAHACHI HIROYUKI,YOSHIMASA TAKAAKI,NAKAO KAZUWA,YOSHIMASA YASUNAO,KOSHIYAMA HIROYUKI,SUGIYAMA KYOKO,OKIGAKI MITSUHIKO,YAMADA TAKAYUKI,ISHII HITOSHI,YAGURA TOSHIHIRO,FUJIMOTO KAZUMITSU
- Endocrine Journal 44(1), 175-180, 1997
- … The mutations of the preproparathyroid hormone (preproPTH) gene have been reported to cause some cases of familial isolated hypoparathyroidism (FIH). … We investigated the preproPTH gene of five affected subjects of three Japanese kindreds with FIH. … Exons 1, 2 and 3 of the preproPTH gene and its exon-intron boundaries were analyzed with either polymerase chain reaction and single strand conformational polymorphism, or direct sequencing of the amplified DNA. …
- NAID 130003549721
- High phosphorus diet increases preproPTH mRNA independent of calcium and calcitriol in normal rats.
- HERNANDEZ A
- Kidney Int., 50, 1872-1878, 1996
- NAID 30027672534
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