プレニラミン
- 関
- prenylamine lactate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/19 02:23:09」(JST)
[Wiki en表示]
Prenylamine
|
Systematic (IUPAC) name |
(RS)-N-(1-methyl-2-phenylethyl)-3,3-diphenylpropan-1-amine
|
Clinical data |
Routes of
administration |
Oral |
Legal status |
|
Identifiers |
CAS Number |
390-64-7 N |
ATC code |
C01DX02 (WHO) |
PubChem |
CID 9801 |
ChemSpider |
9418 N |
UNII |
K2OH82Z000 N |
ChEMBL |
CHEMBL24072 N |
Synonyms |
N-(3,3-diphenylpropyl)amphetamine |
Chemical data |
Formula |
C24H27N |
Molar mass |
329.48 g/mol |
SMILES
-
CC(Cc1ccccc1)NCCC(c2ccccc2)c3ccccc3
|
InChI
-
InChI=1S/C24H27N/c1-20(19-21-11-5-2-6-12-21)25-18-17-24(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,20,24-25H,17-19H2,1H3 N
-
Key:IFFPICMESYHZPQ-UHFFFAOYSA-N N
|
NY (what is this?) (verify) |
Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class which is used as a vasodilator in the treatment of angina pectoris. It has been shown to partially metabolize to amphetamine and can cause false positives for it in drug tests.[1][2][3] Prenylamine also appears to act as a vesicular monoamine transporter inhibitor, and has been demonstrated to deplete vesicular monoamine neurotransmitter stores similarly to reserpine.[4]
References
- ^ Kraemer T, Roditis SK, Peters FT, Maurer HH (March 2003). "Amphetamine concentrations in human urine following single-dose administration of the calcium antagonist prenylamine-studies using fluorescence polarization immunoassay (FPIA) and GC-MS". Journal of Analytical Toxicology 27 (2): 68–73. doi:10.1093/jat/27.2.68. PMID 12669999.
- ^ Musshoff F (February 2000). "Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine". Drug Metabolism Reviews 32 (1): 15–44. doi:10.1081/DMR-100100562. PMID 10711406.
- ^ Cody JT (May 2002). "Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results". Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine 44 (5): 435–50. doi:10.1097/00043764-200205000-00012. PMID 12024689.
- ^ Bagchi SP (1990). "Antidopaminergic action of verapamil and several other drugs: inactivation of vesicular dopamine". Life Sciences 46 (12): 857–63. doi:10.1016/0024-3205(90)90115-8. PMID 1969603.
Vasodilators used in cardiac diseases (C01D)
|
|
Nitrovasodilators |
- Nitroglycerin #
- Isosorbide dinitrate #
- Isosorbide mononitrate
- Linsidomine
- Molsidomine
- Nicorandil
- Pentaerythritol tetranitrate
- Propatylnitrate
- Tenitramine
- Trolnitrate
|
|
Quinolone vasodilators |
|
|
Others |
- Benziodarone
- Carbocromen
- Cinepazet
- Cloridarol
- Dilazep
- Efloxate
- Etafenone
- Gapicomine
- Heptaminol
- Hexobendine
- Imolamine
- Itramin tosilate
- Levosimendan
- Nesiritide
- Nicorandil
- Oxyfedrine
- Pimobendan
- Prenylamine
- Serelaxin
- Trapidil
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
Stimulants (N06B)
|
|
Adamantanes |
- Adaphenoxate
- Adapromine
- Amantadine
- Bromantane
- Chlodantane
- Gludantane
- Memantine
- Rimantadine
|
|
Adenosine antagonists |
- 8-Chlorotheophylline
- 8-Cyclopentyltheophylline
- 8-Phenyltheophylline
- Aminophylline
- Caffeine
- CGS-15943
- Dimethazan
- Paraxanthine
- SCH-58261
- Theobromine
- Theophylline
|
|
Alkylamines |
- Cyclopentamine
- Cypenamine
- Cyprodenate
- Heptaminol
- Isometheptene
- Methylhexaneamine
- Octodrine
- Propylhexedrine
- Tuaminoheptane
|
|
Ampakines |
- CX-516
- CX-546
- CX-614
- CX-691
- CX-717
- IDRA-21
- LY-404,187
- LY-503,430
- Nooglutyl
- Org 26576
- PEPA
- S-18986
- Sunifiram
- Unifiram
|
|
Arylcyclohexylamines |
- Benocyclidine
- Dieticyclidine
- Esketamine
- Eticyclidine
- Gacyclidine
- Ketamine
- Phencyclamine
- Phencyclidine
- Rolicyclidine
- Tenocyclidine
- Tiletamine
|
|
Benzazepines |
- 6-Br-APB
- SKF-77434
- SKF-81297
- SKF-82958
|
|
Cholinergics |
- A-84,543
- A-366,833
- ABT-202
- ABT-418
- AR-R17779
- Altinicline
- Anabasine
- Arecoline
- Bradanicline
- Cotinine
- Cytisine
- Dianicline
- Epibatidine
- Epiboxidine
- GTS-21
- Ispronicline
- Nicotine
- PHA-543,613
- PNU-120,596
- PNU-282,987
- Pozanicline
- Rivanicline
- Sazetidine A
- SIB-1553A
- SSR-180,711
- TC-1698
- TC-1827
- TC-2216
- Tebanicline
- UB-165
- Varenicline
- WAY-317,538
|
|
Convulsants |
- Anatoxin-a
- Bicuculline
- DMCM
- Flurothyl
- Gabazine
- Pentetrazol
- Picrotoxin
- Strychnine
- Thujone
|
|
Eugeroics |
- Adrafinil
- Armodafinil
- CRL-40,940
- CRL-40,941
- Fluorenol
- JZ-IV-10
- Modafinil
|
|
Oxazolines |
- 4-Methylaminorex
- Aminorex
- Clominorex
- Cyclazodone
- Fenozolone
- Fluminorex
- Pemoline
- Thozalinone
|
|
Phenethylamines |
- 1-(4-Methylphenyl)-2-aminobutane
- 1-Phenyl-2-(piperidin-1-yl)pentan-3-one
- 1-Methylamino-1-(3,4-methylenedioxyphenyl)propane
- 2-Fuoroamphetamine
- 2-Fuoromethamphetamine
- 2-OH-PEA
- 2-Phenyl-3-aminobutane
- 2-Phenyl-3-methylaminobutane
- 2,3-MDA
- 3-Fuoroamphetamine
- 3-Fluoroethamphetamine
- 3-Fluoromethcathinone
- 3-Methoxyamphetamine
- 3-Methylamphetamine
- 3,4-DMMC
- 4-BMC
- 4-CMC
- 4-Ethylamphetamine
- 4-Fluoroamphetamine
- 4-Fluoromethamphetamine
- 4-MA
- 4-Methylbuphedrone
- 4-Methylcathinone
- 4-MMA
- 4-Methylpentedrone
- 4-MTA
- 6-FNE
- AL-1095
- Alfetamine
- a-Ethylphenethylamine
- Amfecloral
- Amfepentorex
- Amfepramone
- Amidephrine
- 2-Amino-1,2-dihydronaphthalene
- 2-Aminoindane
- 5-(2-Aminopropyl)indole
- 2-Aminotetralin
- Acridorex
- Amphetamine (Dextroamphetamine, Levoamphetamine)
- Amphetaminil
- Arbutamine
- β-Methylphenethylamine
- β-Phenylmethamphetamine
- Benfluorex
- Benzedrone
- Benzphetamine
- BDB
- BOH
- 3-Benzhydrylmorpholine
- BPAP
- Buphedrone
- Bupropion
- Butylone
- Camfetamine
- Cathine
- Cathinone
- Chlorphentermine
- Cilobamine
- Cinnamedrine
- Clenbuterol
- Clobenzorex
- Cloforex
- Clortermine
- Cypenamine
- D-Deprenyl
- Denopamine
- Dimethoxyamphetamine
- Dimethylamphetamine
- Dimethylcathinone
- Dobutamine
- DOPA (Dextrodopa, Levodopa)
- Dopamine
- Dopexamine
- Droxidopa
- EBDB
- Ephedrine
- Epinephrine
- Epinine
- Etafedrine
- Ethcathinone
- Ethylnorepinephrine
- Ethylone
- Etilamfetamine
- Etilefrine
- Famprofazone
- Fencamfamine
- Fencamine
- Fenethylline
- Fenfluramine (Dexfenfluramine, Levofenfluramine)
- Fenproporex
- Feprosidnine
- Flephedrone
- Fludorex
- Formetorex
- Furfenorex
- Gepefrine
- Hexapradol
- HMMA
- Hordenine
- 4-Hydroxyamphetamine
- 5-Iodo-2-aminoindane
- Ibopamine
- IMP
- Indanylamphetamine
- Iofetamine
- Isoetarine
- Isoethcathinone
- Isoprenaline
- L-Deprenyl (Selegiline)
- Lefetamine
- Lisdexamfetamine
- Lophophine
- MBDB
- MDA
- MDBU
- MDEA
- MDMA
- MDMPEA
- MDOH
- MDPR
- MDPEA
- Mefenorex
- Mephedrone
- Mephentermine
- Metanephrine
- Metaraminol
- Mesocarb
- Methamphetamine (Dextromethamphetamine, Levomethamphetamine)
- Methoxamine
- Methoxyphenamine
- MMA
- Methcathinone
- Methedrone
- Methoxyphenamine
- Methylenedioxycathinone
- Methylone
- Mexedrone
- MMDA
- MMDMA
- MMMA
- Morforex
- N,alpha-Diethylphenylethylamine
- N-Benzyl-1-phenethylamine
- N-Ethylbuphedrone
- N,N-Dimethylphenethylamine
- Naphthylamphetamine
- Nisoxetine
- Norepinephrine
- Norfenefrine
- Norfenfluramine
- Normetanephrine
- L-Norpseudoephedrine
- Octopamine (drug)
- Orciprenaline
- Ortetamine
- Oxifentorex
- Oxilofrine
- PBA
- PCA
- PCMA
- PHA
- Pentorex
- Pentedrone
- Pentylone
- Phenatine
- Phenpromethamine
- Phentermine
- Phenylalanine
- Phenylephrine
- Phenylpropanolamine
- Pholedrine
- PIA
- PMA
- PMEA
- PMMA
- PPAP
- Phthalimidopropiophenone
- Prenylamine
- Propylamphetamine
- Pseudoephedrine
- Ropinirole
- Salbutamol (Levosalbutamol)
- Sibutramine
- Synephrine
- Theodrenaline
- Tiflorex
- Tranylcypromine
- Tyramine
- Tyrosine
- Xylopropamine
- Zylofuramine
|
|
Phenylmorpholines |
- 3-Fluorophenmetrazine
- Fenbutrazate
- Fenmetramide
- G-130
- Manifaxine
- Morazone
- Morforex
- Oxaflozane
- PD-128,907
- Phendimetrazine
- Phenmetrazine
- 2-Phenyl-3,6-dimethylmorpholine
- Pseudophenmetrazine
- Radafaxine
|
|
Piperazines |
- 2C-B-BZP
- 3C-PEP
- BZP
- CM156
- DBL-583
- GBR-12783
- GBR-12935
- GBR-13069
- GBR-13098
- GBR-13119
- MeOPP
- MBZP
- Vanoxerine
|
|
Piperidines |
- 1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine
- 1-(3,4-Dichlorophenyl)-1-(piperidin-2-yl)butane
- 2-Benzylpiperidine
- 2-Methyl-3-phenylpiperidine
- 3-Chloromethylphenidate
- 3,4-Dichloromethylphenidate
- 4-Benzylpiperidine
- 4-Fluoromethylphenidate
- 4-Methylmethylphenidate
- Desoxypipradrol
- Difemetorex
- Diphenylpyraline
- Ethylnaphthidate
- Ethylphenidate
- Methylnaphthidate
- Isopropylphenidate
- Methylphenidate (Dexmethylphenidate)
- N-Methyl-3β-propyl-4β-(4-chlorophenyl)piperidine
- Nocaine
- Phacetoperane
- Pipradrol
- Propylphenidate
- SCH-5472
|
|
Pyrrolidines |
- 2-Diphenylmethylpyrrolidine
- 5-DBFPV
- α-PPP
- α-PBP
- α-PHP
- α-PVP
- α-PVT
- Diphenylprolinol
- DMPVP
- FPOP
- FPVP
- MDPPP
- MDPBP
- MPBP
- MPHP
- MPPP
- MOPVP
- MOPPP
- Indapyrophenidone
- MDPV
- Naphyrone
- PEP
- Picilorex
- Prolintane
- Pyrovalerone
|
|
Racetams |
- Oxiracetam
- Phenylpiracetam
- Phenylpiracetam hydrazide
|
|
Tropanes |
- 3-CPMT
- 3'-Chloro-3a-(diphenylmethoxy)tropane
- 4-fluorotropacocaine
- 4'-Fluorococaine
- AHN-1055
- Altropane (IACFT)
- Brasofensine
- CFT (WIN 35,428)
- β-CIT (RTI-55)
- Cocaethylene
- Cocaine
- Dichloropane (RTI-111)
- Difluoropine
- FE-β-CPPIT
- FP-β-CPPIT
- Ioflupane (123I)
- Norcocaine
- PIT
- PTT
- RTI-31
- RTI-32
- RTI-51
- RTI-105
- RTI-112
- RTI-113
- RTI-117
- RTI-120
- RTI-121 (IPCIT)
- RTI-126
- RTI-150
- RTI-154
- RTI-171
- RTI-177
- RTI-183
- RTI-193
- RTI-194
- RTI-199
- RTI-202
- RTI-204
- RTI-229
- RTI-241
- RTI-336
- RTI-354
- RTI-371
- RTI-386
- Salicylmethylecgonine
- Tesofensine
- Troparil (β-CPT, WIN 35,065-2)
- Tropoxane
- WF-23
- WF-33
- WF-60
|
|
Tryptamines |
- 4-HO-αMT
- 4-Methyl-αET
- 4-Methyl-αMT
- 5-Chloro-αMT
- 5-Fluoro-αMT
- 5-MeO-αET
- 5-MeO-αMT
- 5-MeO-DIPT
- 6-Fluoro-αMT
- 7-Methyl-αET
- αET
- αMT
|
|
Others |
- 2-MDP
- 2-Phenylcyclohexylamine
- 3,3-Diphenylcyclobutanamine
- Amfonelic acid
- Amineptine
- Amiphenazole
- Atipamezole
- Atomoxetine
- Bemegride
- Benzydamine
- BTQ
- BTS 74,398
- Centanafadine
- Ciclazindol
- Clofenciclan
- Cropropamide
- Crotetamide
- D-161
- Diclofensine
- Dimethocaine
- Efaroxan
- Etamivan
- Fenisorex
- Fenpentadiol
- Gamfexine
- Gilutensin
- GSK1360707F
- GYKI-52895
- Hexacyclonate
- Idazoxan
- Indanorex
- Indatraline
- JNJ-7925476
- Lazabemide
- Leptacline
- Levopropylhexedrine
- Lomevactone
- LR-5182
- Mazindol
- Meclofenoxate
- Medifoxamine
- Mefexamide
- Methamnetamine
- Methastyridone
- Methiopropamine
- Naphthylaminopropane
- Nefopam
- Nikethamide
- Nomifensine
- O-2172
- Oxaprotiline
- PNU-99,194
- Propylhexedrine
- PRC200-SS
- Rasagiline
- Rauwolscine
- Rubidium chloride
- Setazindol
- Tametraline
- Tandamine
- Thiopropamine
- Thiothinone
- Trazium
- UH-232
- Yohimbine
|
|
- Category
- Index
- Outline
- Portal
|
|
Dopaminergics
|
|
Receptor ligands
|
|
DR |
Agonists |
- Adamantanes
- Amantadine
- Memantine
- Rimantadine
|
|
- Aminotetralins
- 7-OH-DPAT
- 8-OH-PBZI
- Rotigotine
- UH-232
|
|
- Benzazepines
- 6-Br-APB
- Fenoldopam
- SKF-38,393
- SKF-77,434
- SKF-81,297
- SKF-82,958
- SKF-83,959
|
|
- Ergolines
- Bromocriptine
- Cabergoline
- Dihydroergocryptine
- Epicriptine
- Lisuride
- LSD
- Pergolide
|
|
- Dihydrexidine derivatives
- 2-OH-NPA
- A-86929
- Adrogolide (ABT-431, DAS-431)
- Ciladopa
- Dihydrexidine
- Dinapsoline
- Dinoxyline
- Doxanthrine
|
|
- Others
- A-68930
- A-77636
- A-412,997
- ABT-670
- ABT-724
- Aplindore
- Apomorphine
- Aripiprazole
- Arketamine
- Bifeprunox
- BP-897
- Captodiame
- CY-208,243
- Dizocilpine
- Esketamine
- Etilevodopa
- Flibanserin
- Ketamine
- Melevodopa
- Modafinil
- Pardoprunox
- Phencyclidine
- PD-128,907
- PD-168,077
- PF-219,061
- Piribedil
- Pramipexole
- Propylnorapomorphine
- Pukateine
- Quinagolide
- Quinelorane
- Quinpirole
- RDS-127
- Ro10-5824
- Ropinirole
- Rotigotine
- Roxindole
- Salvinorin A
- SKF-89,145
- Sumanirole
- Terguride
- Umespirone
- WAY-100,635
|
|
|
Antagonists |
- Typical antipsychotics
- Acepromazine
- Azaperone
- Benperidol
- Bromperidol
- Clopenthixol
- Chlorpromazine
- Chlorprothixene
- Droperidol
- Flupentixol
- Fluphenazine
- Fluspirilene
- Haloperidol
- Levomepromazine
- Levosulpiride
- Loxapine
- Mesoridazine
- Nemonapride
- Penfluridol
- Perazine
- Periciazine
- Perphenazine
- Pimozide
- Prochlorperazine
- Promazine
- Sulforidazine
- Sulpiride
- Sultopride
- Thioridazine
- Thiothixene
- Trifluoperazine
- Triflupromazine
- Trifluperidol
- Zuclopenthixol
|
|
- Atypical antipsychotics
- Amisulpride
- Asenapine
- Blonanserin
- Cariprazine
- Carpipramine
- Clocapramine
- Clorotepine
- Clozapine
- Gevotroline
- Iloperidone
- Lurasidone
- Melperone
- Molindone
- Mosapramine
- Olanzapine
- Paliperidone
- Perospirone
- Piquindone
- Quetiapine
- Remoxipride
- Risperidone
- Sertindole
- Tiospirone
- Zicronapine
- Ziprasidone
- Zotepine
|
|
- Antiemetics
- AS-8112
- Alizapride
- Bromopride
- Clebopride
- Domperidone
- Metoclopramide
- Thiethylperazine
|
|
- Others
- Amoxapine
- Buspirone
- Butaclamol
- Ecopipam
- EEDQ
- Eticlopride
- Fananserin
- Hydroxyzine
- L-745,870
- Nafadotride
- Nuciferine
- PNU-99,194
- Raclopride
- Sarizotan
- SB-277,011-A
- SCH 23390
- SKF-83,959
- Sonepiprazole
- Spiperone
- Spiroxatrine
- Stepholidine
- Tetrahydropalmatine
- Tiapride
- UH-232
- Yohimbine
|
|
|
|
|
|
Reuptake modulators
|
|
DAT |
Inhibitors |
- Piperazines
- DBL-583
- GBR-12783
- GBR-12935
- GBR-13069
- GBR-13098
- Nefazodone
- Vanoxerine
|
|
- Piperidines
- 4-Fluoropethidine
- Benocyclidine (BTCP)
- Desoxypipradrol
- Dexmethylphenidate
- Difemetorex
- Ethylphenidate
- HDMP-28
- Methylphenidate
- Pethidine (meperidine)
- Phencyclidine
- Pipradrol
|
|
- Pyrrolidines
- Diphenylprolinol
- MDPV
- Naphyrone
- Prolintane
- Pyrovalerone
|
|
- Tropanes
- Altropane
- Benzatropine (benztropine)
- Brasofensine
- CFT
- Cocaine
- Dichloropane
- Difluoropine
- Etybenzatropine (ethybenztropine)
- FE-β-CPPIT
- FP-β-CPPIT
- Ioflupane (123I)
- RTI-55
- RTI-112
- RTI-113
- RTI-121
- RTI-126
- RTI-150
- RTI-177
- RTI-229
- RTI-336
- Tenocyclidine
- Tesofensine
- Troparil
- Tropoxane
- WF-11
- WF-23
- WF-31
- WF-33
|
|
- Others
- Adrafinil
- Amifitadine
- Armodafinil
- Amfonelic acid
- Amineptine
- Ansofaxine
- BTQ
- BTS 74,398
- Bupropion
- Chaenomeles speciosa
- Ciclazindol
- Dasotraline
- Desmethylsertraline
- Diclofensine
- Dimethocaine
- Diphenylpyraline
- Dizocilpine (MK-801)
- DOV-102,677
- DOV-216,303
- Efavirenz
- Esketamine
- EXP-561
- Fencamfamine
- Fezolamine
- Fluorenol
- GYKI-52895
- Indatraline
- Ketamine
- Lefetamine
- Levophacetoperane
- Liafensine
- LR-5182
- Manifaxine
- Mazindol
- Medifoxamine
- Mesocarb
- Metaphit
- MIN-117 (WF-516)
- Modafinil
- Nefopam
- Nomifensine
- NS-2359
- O-2172
- Oroxylin A
- Perafensine
- Pridefine
- Radafaxine
- Rimcazole
- Sertraline
- Sibutramine
- Tametraline
- Tedatioxetine
- Tripelennamine
- Venlafaxine
|
|
|
Enhancers |
|
|
Modulators |
|
|
- Antagonist-like
- SoRI-20041
|
|
|
|
VMATs |
- Inhibitors
- Amiodarone
- Amphetamines (e.g., amphetamine, methamphetamine, MDMA)
- Bietaserpine
- Deserpidine
- Efavirenz
- GBR-12935
- Ibogaine
- Ketanserin
- Lobeline
- Reserpine
- Rose bengal
- Tetrabenazine
- Vanoxerine (GBR-12909)
|
|
|
|
Releasing agents
|
|
- Morpholines
- Fenbutrazate
- Fenmetramide
- Morazone
- Morforex
- Phendimetrazine
- Phenmetrazine
- Pseudophenmetrazine
|
|
- Oxazolines
- 4-MAR
- Aminorex
- Clominorex
- Cyclazodone
- Fenozolone
- Fluminorex
- Pemoline
- Thozalinone
|
|
- Phenethylamines (also amphetamines, cathinones, etc)
- 2-OH-PEA
- 4-CAB
- 4-FA
- 4-FMA
- 4-MA
- 4-MMA
- Alfetamine
- Amfecloral
- Amfepentorex
- Amfepramone
- Amphetamine (Dextroamphetamine
- Levoamphetamine)
- Amphetaminil
- β-Me-PEA
- BDB
- BOH
- Benzphetamine
- Buphedrone
- Bupropion
- Butylone
- Cathine
- Cathinone
- Clobenzorex
- Clortermine
- D-Deprenyl
- DMA
- DMMA
- Dimethylamphetamine
- Ephedrine
- Ethcathinone
- EBDB
- Ethylone
- Etilamfetamine
- Famprofazone
- Fenethylline
- Fenproporex
- Flephedrone
- Fludorex
- Furfenorex
- Hordenine
- 4-Hydroxyamphetamine
- Iofetamine (123I)
- Lophophine
- Mefenorex
- Mephedrone
- Metamfepramone
- Methamphetamine
- Dextromethamphetamine
- Levomethamphetamine
- Methcathinone
- Methedrone
- MMDA
- MMDMA
- MBDB
- MDA
- MDEA
- MDMA
- MDMPEA
- MDOH
- MDPEA
- Methylone
- Morforex
- Ortetamine
- pBA
- pCA
- pIA
- Pholedrine
- Phenethylamine
- Pholedrine
- Phenpromethamine
- Prenylamine
- Propylamphetamine
- Pseudoephedrine
- Tiflorex
- Tyramine
- Xylopropamine
- Zylofuramine
|
|
- Piperazines
- 2C-B-BZP
- BZP
- MBZP
- MDBZP
- MeOPP
|
|
- Others
- 2-ADN
- 2-AI
- 2-AT
- 4-BP
- 5-APDI
- 5-IAI
- Clofenciclan
- Cyclopentamine
- Cypenamine
- Cyprodenate
- Feprosidnine
- Gilutensin
- Heptaminol
- Hexacyclonate
- Indanorex
- Isometheptene
- Methylhexanamine
- Naphthylaminopropane
- Octodrine
- Phthalimidopropiophenone
- Phenylbiguanide
- Propylhexedrine
- Levopropylhexedrine
- Tuaminoheptane
|
|
|
|
Enzyme inhibitors
|
|
PAH |
|
|
TH |
- 3-Iodotyrosine
- Aquayamycin
- Bulbocapnine
- Metirosine
- Oudenone
|
|
AAAD |
- Benserazide
- Carbidopa
- DFMD
- Genistein
- Methyldopa
|
|
MAO |
- Nonselective
- Benmoxin
- Caroxazone
- Echinopsidine
- Furazolidone
- Hydralazine
- Indantadol
- Iproclozide
- Iproniazid
- Isocarboxazid
- Isoniazid
- Linezolid
- Mebanazine
- Metfendrazine
- Nialamide
- Octamoxin
- Paraxazone
- Phenelzine
- Pheniprazine
- Phenoxypropazine
- Pivhydrazine
- Procarbazine
- Safrazine
- Tranylcypromine
|
|
- MAO-A selective
- Amiflamine
- Bazinaprine
- Befloxatone
- Brofaromine
- Cimoxatone
- Clorgiline
- CX157 (Tyrima)
- Eprobemide
- Esuprone
- Harmala alkaloids
- Methylene Blue
- Metralindole
- Minaprine
- Moclobemide
- Pirlindole
- Sercloremine
- Tetrindole
- Toloxatone
|
|
- MAO-B selective
- Almoxatone
- D-Deprenyl
- Ethanol
- Ladostigil
- Lazabemide
- Milacemide
- Nicotine
- Pargyline‡
- Rasagiline
- Safinamide
- Selegiline (L-Deprenyl)
|
|
|
COMT |
- Entacapone
- Nitecapone
- Tolcapone
|
|
DBH |
- Disulfiram
- Dopastin
- Fusaric acid
- Nepicastat
- Tropolone
|
|
|
|
Others
|
|
Precursors |
- L-Phenylalanine → L-Tyrosine → L-DOPA (levodopa)
|
|
Cofactors |
- Ferrous iron (Fe2+)
- Tetrahydrobiopterin
- Vitamin B3 (Niacin
- Nicotinamide → NADPH)
- Vitamin B6 (Pyridoxine
- Pyridoxamine
- Pyridoxal → Pyridoxal phosphate)
- Vitamin B9 (Folic acid → Tetrahydrofolic acid)
- Vitamin C (Ascorbic acid)
- Zinc (Zn2+)
|
|
Neurotoxins |
- Amphetamine
- Methamphetamine
- MPP+
- MPTP
- Norsalsolinol
- Oxidopamine (6-OHDA)
- Rotenone
|
|
Others |
- Activity enhancers
- BPAP
- PPAP
|
|
- Levodopa prodrugs
- XP21279
|
|
- Others
- Bromantane (dopamine synthesis enhancer)
|
|
|
|
|
- See also:
- Adrenergics
- Melatonergics
- Serotonergics
- List of dopaminergic drugs
|
|
English Journal
- Treatment for calcium channel blocker poisoning: a systematic review.
- St-Onge M1, Dubé PA, Gosselin S, Guimont C, Godwin J, Archambault PM, Chauny JM, Frenette AJ, Darveau M, Le Sage N, Poitras J, Provencher J, Juurlink DN, Blais R.
- Clinical toxicology (Philadelphia, Pa.).Clin Toxicol (Phila).2014 Nov;52(9):926-44. doi: 10.3109/15563650.2014.965827. Epub 2014 Oct 6.
- CONTEXT: Calcium channel blocker poisoning is a common and sometimes life-threatening ingestion.OBJECTIVE: To evaluate the reported effects of treatments for calcium channel blocker poisoning. The primary outcomes of interest were mortality and hemodynamic parameters. The secondary outcomes included
- PMID 25283255
- Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1.
- Raphemot R1, Kadakia RJ, Olsen ML, Banerjee S, Days E, Smith SS, Weaver CD, Denton JS.
- Assay and drug development technologies.Assay Drug Dev Technol.2013 Nov-Dec;11(9-10):532-43. doi: 10.1089/adt.2013.544. Epub 2013 Nov 22.
- The inward rectifier potassium (Kir) channel Kir4.1 plays essential roles in modulation of neurotransmission and renal sodium transport and may represent a novel drug target for temporal lobe epilepsy and hypertension. The molecular pharmacology of Kir4.1 is limited to neurological drugs, such as fl
- PMID 24266659
- Identification and characterization of urinary prenylamine metabolites by means of liquid chromatography-tandem mass spectrometry.
- Beuck S1, Sigmund G, Koch A, Schänzer W, Pokrywka A, Kwiatkowska D, Thevis M.
- Drug testing and analysis.Drug Test Anal.2012 Sep;4(9):701-16. doi: 10.1002/dta.1388. Epub 2012 Jul 12.
- Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate
- PMID 22786790
Japanese Journal
- High-Speed Screening and Structure-Activity Relationship Analysis for the Substrate Specificity of P-Glycoprotein (ABCB1)
- 大西 裕子,平野 弘之,中田 國夫,大隅 啓輔,長倉 誠,樽井 茂樹,石川 智久
- Chem-Bio Informatics Journal 3, 175-193, 2003
- P-糖蛋白質(ABCB1/MDR1)は、薬物の細胞外への排出を行い、薬物体内動態に関して重要な役割を担う。本研究において、我々は多種多様な薬物および化合物に対するP-糖蛋白質(ABCB1)の基質特異性を解析する高速スクリーニング法を開発した。基本的には、P-糖蛋白質(ABCB1)をSf9昆虫細胞で発現させ、ATPase活性を測定するものである。41種類の市販薬および化合物の中で、Ca2+チャネル拮 …
- NAID 130004138151
- Effect of a Prenylamine Analog(MG8926) on Spontaneous Action Potentials in Isolated Rabbit Sinoatrial Node
- 中西 弘則,松岡 功,小野 委成,吉田 廣英,内堀 剛洋,古城 健太郎
- Fukushima journal of medical science 42(1/2), 1-10, 1996-12
- NAID 10016293914
- Caきっ抗薬の抗心室細動作用に関する研究 Procainamideとの比較:―Procainamideとの比較―
- 佐藤 毅,太田 晃,矢崎 吉純,関谷 宗一郎,堤 健,春見 建一
- 心電図 9(2), 211-219, 1989
- … erval曲線で表される心筋興奮性から, Ca拮抗薬の3薬剤, verapamil, prenylamine, bepridilの抗心室細動効果, およびその作用機序をprocainamideと比較し, これら3薬剤の抗細動作用の特徴を臨床使用量に近い量を用いて検討した.心室細動閾値は, procainamide 10mg/kgで48%, prenylamine 5mg/kgで127%, bepridil 5mg/kgで104%の上昇が生じ (p<0.01) , prenylamine, bepridilはprocainamideを上回る抗心室細動作用を示した.一方, …
- NAID 130004245892
Related Links
- Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class which is used as a vasodilator in the treatment of angina pectoris. It has been shown to partially metabolize to amphetamine and can cause false ...
- 11 Sep 2007 ... Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias. Structure, Thumb Download: MOL | SDF | SMILES | InChI. Display: 2D Structure | 3D Structure ...
Related Pictures
![Prenylamine.svg](https://1mg.info/0/3/y/1017.jpg)
![prenylamine y methylhexanemina. ESPECIAL](https://1mg.info/0/3/y/1018.jpg)
![Mdma Structure File:prenylamine-mdma.png](https://1mg.info/0/3/y/1019.jpg)
![Size of this preview: 800 × 600 pixels](https://1mg.info/0/3/y/1020.jpg)
![Agents Bepridil* Lipoflazine* Prenylamine](https://1mg.info/0/3/y/1021.jpg)
★リンクテーブル★
[★]
- 英
- prenylamine、prenylamine lactate
- 関
- 乳酸プレニラミン
[★]
- 関
- prenylamine