関: prenylamine lactate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/19 02:23:09」(JST)

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Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class which is used as a vasodilator in the treatment of angina pectoris. It has been shown to partially metabolize to amphetamine and can cause false positives for it in drug tests.^[1]^[2]^[3] Prenylamine also appears to act as a vesicular monoamine transporter inhibitor, and has been demonstrated to deplete vesicular monoamine neurotransmitter stores similarly to reserpine.^[4]

References

^ Kraemer T, Roditis SK, Peters FT, Maurer HH (March 2003). "Amphetamine concentrations in human urine following single-dose administration of the calcium antagonist prenylamine-studies using fluorescence polarization immunoassay (FPIA) and GC-MS". Journal of Analytical Toxicology 27 (2): 68–73. doi:10.1093/jat/27.2.68. PMID 12669999.
^ Musshoff F (February 2000). "Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine". Drug Metabolism Reviews 32 (1): 15–44. doi:10.1081/DMR-100100562. PMID 10711406.
^ Cody JT (May 2002). "Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results". Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine 44 (5): 435–50. doi:10.1097/00043764-200205000-00012. PMID 12024689.
^ Bagchi SP (1990). "Antidopaminergic action of verapamil and several other drugs: inactivation of vesicular dopamine". Life Sciences 46 (12): 857–63. doi:10.1016/0024-3205(90)90115-8. PMID 1969603.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

English Journal

Treatment for calcium channel blocker poisoning: a systematic review.

St-Onge M1, Dubé PA, Gosselin S, Guimont C, Godwin J, Archambault PM, Chauny JM, Frenette AJ, Darveau M, Le Sage N, Poitras J, Provencher J, Juurlink DN, Blais R.
Clinical toxicology (Philadelphia, Pa.).Clin Toxicol (Phila).2014 Nov;52(9):926-44. doi: 10.3109/15563650.2014.965827. Epub 2014 Oct 6.
CONTEXT: Calcium channel blocker poisoning is a common and sometimes life-threatening ingestion.OBJECTIVE: To evaluate the reported effects of treatments for calcium channel blocker poisoning. The primary outcomes of interest were mortality and hemodynamic parameters. The secondary outcomes included
PMID 25283255

Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1.

Raphemot R1, Kadakia RJ, Olsen ML, Banerjee S, Days E, Smith SS, Weaver CD, Denton JS.
Assay and drug development technologies.Assay Drug Dev Technol.2013 Nov-Dec;11(9-10):532-43. doi: 10.1089/adt.2013.544. Epub 2013 Nov 22.
The inward rectifier potassium (Kir) channel Kir4.1 plays essential roles in modulation of neurotransmission and renal sodium transport and may represent a novel drug target for temporal lobe epilepsy and hypertension. The molecular pharmacology of Kir4.1 is limited to neurological drugs, such as fl
PMID 24266659

Identification and characterization of urinary prenylamine metabolites by means of liquid chromatography-tandem mass spectrometry.

Beuck S1, Sigmund G, Koch A, Schänzer W, Pokrywka A, Kwiatkowska D, Thevis M.
Drug testing and analysis.Drug Test Anal.2012 Sep;4(9):701-16. doi: 10.1002/dta.1388. Epub 2012 Jul 12.
Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate
PMID 22786790

Japanese Journal

High-Speed Screening and Structure-Activity Relationship Analysis for the Substrate Specificity of P-Glycoprotein (ABCB1)

大西裕子,平野弘之,中田國夫,大隅啓輔,長倉誠,樽井茂樹,石川智久
Chem-Bio Informatics Journal 3, 175-193, 2003
P-糖蛋白質(ABCB1/MDR1)は、薬物の細胞外への排出を行い、薬物体内動態に関して重要な役割を担う。本研究において、我々は多種多様な薬物および化合物に対するP-糖蛋白質(ABCB1)の基質特異性を解析する高速スクリーニング法を開発した。基本的には、P-糖蛋白質(ABCB1)をSf9昆虫細胞で発現させ、ATPase活性を測定するものである。41種類の市販薬および化合物の中で、Ca2+チャネル拮 …
NAID 130004138151

Effect of a Prenylamine Analog(MG8926) on Spontaneous Action Potentials in Isolated Rabbit Sinoatrial Node

中西弘則,松岡功,小野委成,吉田廣英,内堀剛洋,古城健太郎
Fukushima journal of medical science 42(1/2), 1-10, 1996-12
NAID 10016293914

Ｃａきっ抗薬の抗心室細動作用に関する研究　　Ｐｒｏｃａｉｎａｍｉｄｅとの比較:―Procainamideとの比較―

佐藤毅,太田晃,矢崎吉純,関谷宗一郎,堤健,春見建一
心電図 9(2), 211-219, 1989
… erval曲線で表される心筋興奮性から, Ca拮抗薬の3薬剤, verapamil, prenylamine, bepridilの抗心室細動効果, およびその作用機序をprocainamideと比較し, これら3薬剤の抗細動作用の特徴を臨床使用量に近い量を用いて検討した.心室細動閾値は, procainamide 10mg/kgで48%, prenylamine 5mg/kgで127%, bepridil 5mg/kgで104%の上昇が生じ (p<0.01) , prenylamine, bepridilはprocainamideを上回る抗心室細動作用を示した.一方, …
NAID 130004245892

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★リンクテーブル★

リンク元	「プレニラミン」
拡張検索	「prenylamine lactate」

「プレニラミン」

Prenylamine
Systematic (IUPAC) name
	(RS)-N-(1-methyl-2-phenylethyl)-3,3-diphenylpropan-1-amine
Clinical data
Routes of; administration	Oral
Legal status	Uncontrolled;
Identifiers
CAS Number	390-64-7
ATC code	C01DX02 (WHO)
PubChem	CID 9801
ChemSpider	9418
UNII	K2OH82Z000
ChEMBL	CHEMBL24072
Synonyms	N-(3,3-diphenylpropyl)amphetamine
Chemical data
Formula	C24H27N
Molar mass	329.48 g/mol
	SMILES CC(Cc1ccccc1)NCCC(c2ccccc2)c3ccccc3 ;
	InChI InChI=1S/C24H27N/c1-20(19-21-11-5-2-6-12-21)25-18-17-24(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,20,24-25H,17-19H2,1H3 ; Key:IFFPICMESYHZPQ-UHFFFAOYSA-N ;
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英: prenylamine、prenylamine lactate
関: 乳酸プレニラミン

「prenylamine lactate」

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乳酸プレニラミン

関: prenylamine

[pmid12669999-1] Kraemer T, Roditis SK, Peters FT, Maurer HH (March 2003). "Amphetamine concentrations in human urine following single-dose administration of the calcium antagonist prenylamine-studies using fluorescence polarization immunoassay (FPIA) and GC-MS". Journal of Analytical Toxicology 27 (2): 68–73. doi:10.1093/jat/27.2.68. PMID 12669999.

[pmid10711406-2] Musshoff F (February 2000). "Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine". Drug Metabolism Reviews 32 (1): 15–44. doi:10.1081/DMR-100100562. PMID 10711406.

[pmid12024689-3] Cody JT (May 2002). "Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results". Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine 44 (5): 435–50. doi:10.1097/00043764-200205000-00012. PMID 12024689.

[pmid1969603-4] Bagchi SP (1990). "Antidopaminergic action of verapamil and several other drugs: inactivation of vesicular dopamine". Life Sciences 46 (12): 857–63. doi:10.1016/0024-3205(90)90115-8. PMID 1969603.

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prenylamine