WordNet
- an antibody that causes precipitation when it unites with its antigen
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/15 11:52:24」(JST)
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A precipitin is an antibody which can precipitate out of a solution upon antigen binding.
Precipitin reaction[edit]
The precipitin reaction provided the first quantitative assay for antibody. The precipitin reaction is based upon the interaction of antigen with antibody leading to the production of antigen-antibody complexes.
To produce a precipitin reaction, varying amounts of soluble antigen are added to a fixed amount of serum containing antibody. As the amount of antigen added:
- In the zone of antibody excess, each molecule of antigen is bound extensively by antibody and crosslinked to other molecules of antigen. The average size of antibody-antigen complex is small; cross-linking between antigen molecules by antibody is rare.
- In the zone of equivalence, the formation of precipitin complexes is optimal. Extensive lattices of antigen and antibody are formed by cross-linking.
- At high concentrations of antigen, the average size of antibody-antigen complexes is once again small because few antibody molecules are available to cross-link antigen molecules together.
The small, soluble immune complexes formed in vivo in the zone of antigen excess can cause a variety of pathological syndromes.
Antibody can only precipitate antigenic substrates that are multivalent—that is, only antigens that have multiple antibody-binding sites epitopes. This allows for the formation of large antigen:antibody complexes.
External links[edit]
- Precipitins at the US National Library of Medicine Medical Subject Headings (MeSH)
- Precipitin tests at the US National Library of Medicine Medical Subject Headings (MeSH)
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English Journal
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- Acta oto-laryngologica.Acta Otolaryngol.2015 Jan;135(1):58-63. doi: 10.3109/00016489.2014.962185. Epub 2014 Nov 5.
- Abstract Conclusion: The sinuses should be considered as a bacterial reservoir and a target for surgery and antibiotic treatment in patients with primary ciliary dyskinesia (PCD). The observed decrease in serum precipitating antibodies (precipitins) against Pseudomonas aeruginosa may indicate a bene
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- Schistosomiasis affects 28 provinces in the Philippines found along the southeastern part where there is continuous rainfall throughout the year. In 2002 and 2005 respectively, two new endemic foci were reported in the northernmost (Gonzaga, Cagayan) and central (Calatrava, Negros Occidental) parts
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Japanese Journal
- Immunochemical Studies on Ribonuclease F1
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- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 848(1), 142-150, 2007-03-15
- NAID 10025793448
Related Links
- Precipitin definition, an antibody that reacts with its specific antigen to form an insoluble precipitate. See more. Dictionary.com Word of the Day Translate Games Blog Thesaurus.com Apps Favorites Log Out Log In Dictionary.com ...
- precipitin 【名】沈降素 特定の抗原に反応して沈殿物(precipitate)に変える... - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。
Related Pictures
★リンクテーブル★
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- 英
- precipitin
- 関
- 沈降反応