反復刺激後過分極
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English Journal
- Suppression of spikes during posttetanic hyperpolarization in auditory neurons: the role of temperature, I(h) currents, and the Na(+)-K(+)-ATPase pump.
- Kim JH, von Gersdorff H.SourceVollum Institute, Oregon Health & Science University, Portland, Oregon, USA. kimjh@uthscsa.edu
- Journal of neurophysiology.J Neurophysiol.2012 Oct;108(7):1924-32. doi: 10.1152/jn.00103.2012. Epub 2012 Jul 11.
- In vivo recordings from postsynaptic neurons in the medial nucleus of the trapezoid body (MNTB), an auditory brain stem nucleus, show that acoustic stimulation produces a burst of spikes followed by a period of hyperpolarization and suppressed spiking activity. The underlying mechanism for this hype
- PMID 22786951
- Blockade of presynaptic K ATP channels reduces the zinc-mediated posttetanic depression at hippocampal mossy fiber synapses.
- Matias CM, Saggau P, Quinta-Ferreira ME.SourceCenter for Neurosciences and Cell Biology, University of Coimbra, 3004-516 Coimbra, Portugal. cmatias@utad.pt
- Brain research.Brain Res.2010 Mar 12;1320:22-7. doi: 10.1016/j.brainres.2010.01.021. Epub 2010 Jan 22.
- Zinc is one of the most abundant transition metals in the brain, being present in a variety of synaptic processes. The mossy fiber terminals in area CA3 of the hippocampus contain large amounts of vesicular zinc and have an extremely high density of ATP-sensitive potassium (KATP) channels. The activ
- PMID 20097182
- [Transformation of electrical activity in the myelinated nerve fibres of amphibia by 4-aminopyridine].
- Kuznetzova IV, Evstigneev DA, Glukhova NV.AbstractUsing the extracellular recording we studied the effect of 4-aminopyridine (4-AP), a potassium channel blocker on the electrical activity of the myelinated nerve fibres of amphibia Rana ridibunda Pallas. Two main types of the reaction on 4-AP were established: extension of the action potential and multi-spike response. In some cases the nerve fibres with multi-spike response generated spontaneous activity without stimulation in the form of bursts of action potentials. During repetitive stimulation 4-AP decreased after-depolarization (at the beginning of the stimulation), the posttetanic after-depolarization and the development of posttetanic after-hyperpolarization. Using the paired stimulation it was established that the spike and after-depolarization of the second action potential depended on the size of after-depolarization after the first action potential. The effects of 4-AP were strongly time-dependent.
- Fiziolohichnyĭ zhurnal (Kiev, Ukraine : 1994).Fiziol Zh.2005;51(2):96-103.
- Using the extracellular recording we studied the effect of 4-aminopyridine (4-AP), a potassium channel blocker on the electrical activity of the myelinated nerve fibres of amphibia Rana ridibunda Pallas. Two main types of the reaction on 4-AP were established: extension of the action potential and m
- PMID 15943238
Related Links
- 1. While much is now known about the Na-K-ATPase and the posttetanic hyperpolarization of nervous tissue, they have yet to be studied together in the same preparation. 2. The post-tetanic hyperpolarization was ...
- Ionic Changes Responsible for Post-tetanic Hyperpolarization P. W. GAGE & JOHN I. HUBBARD Department of Physiology, Australian National University, Canberra. AFTER repetitive stimulation, the membrane potential of nerve ...
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