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occurring immediately after birth; "postnatal development" (同)postpartum

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出産後の

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1. 尿管瘤 ureterocele
2. 続発性羊膜帯 amniotic band sequence
3. 後部尿道弁の臨床症状および診断 clinical presentation and diagnosis of posterior urethral valves
4. 新生児における水痘帯状疱疹ウイルス感染症 varicella zoster infection in the newborn
5. 幼児および小児における小頭症の病因および評価 etiology and evaluation of microcephaly in infants and children

English Journal

Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS.

Markkanen M1, Karhunen T, Llano O, Ludwig A, Rivera C, Uvarov P, Airaksinen MS.Author information 1Department of Anatomy, Institute of Biomedicine, University of Helsinki, FI-00014, Helsinki, Finland.AbstractThe neuronal K-Cl cotransporter KCC2 maintains the low intracellular chloride concentration required for the fast hyperpolarizing actions of inhibitory neurotransmitters in mature central nervous system (CNS). The KCC2 gene produces two isoforms, KCC2a and KCC2b, that differ in their N-termini. Increase of KCC2b in the cortex underlies the developmental shift in γ-aminobutyric acid (GABA)ergic responses, whereas the physiological role of KCC2a is still poorly characterized. The two KCC2 isoforms show equal distribution in mouse brainstem neurons at birth; however their postnatal expression patterns, and the subcellular localization of KCC2a, have not yet been described. Here, we compared the pattern of KCC2a and KCC2b expression in different regions of postnatal mouse CNS by immunohistochemistry by using isoform-specific antibodies. Tissue from KCC2a isoform-specific knockout mice was used as a negative control. KCC2b expression increased postnatally and was widely expressed in adult brain. KCC2a immunoreactivity was low or absent in most parts of the adult cortex, hippocampus, thalamus, and cerebellar cortex. Both isoforms were widely present in the developing and mature hypothalamus, a large part of the brainstem, and the spinal cord. A notable exception was the lack of KCC2a staining in the brainstem auditory system. At the subcellular level, the isoforms were only partially colocalized. In neuronal somas, KCC2b immunoreactivity was concentrated at the plasma membrane, whereas KCC2a signal was not. Moreover, although both isoforms were expressed in microtubule-associated protein (MAP)2-positive dendrites, they appeared in non-overlapping dendritic compartments. The results, together with those of previous studies, suggest that KCC2a and KCC2b have overlapping roles in neonatal neurons but presumably different roles in mature neurons. J. Comp. Neurol. 522:1897-1914, 2014. © 2013 Wiley Periodicals, Inc.
The Journal of comparative neurology.J Comp Neurol.2014 Jun 1;522(8):1897-914. doi: 10.1002/cne.23510.
The neuronal K-Cl cotransporter KCC2 maintains the low intracellular chloride concentration required for the fast hyperpolarizing actions of inhibitory neurotransmitters in mature central nervous system (CNS). The KCC2 gene produces two isoforms, KCC2a and KCC2b, that differ in their N-termini. Incr
PMID 24639001

DCX-expressing cells in the vicinity of the hypothalamic neurogenic niche: A comparative study between mouse, sheep, and human tissues.

Batailler M1, Droguerre M, Baroncini M, Fontaine C, Prevot V, Migaud M.Author information 1INRA, Unité Mixte de Recherche (UMR) 85 Physiologie de la Reproduction et des Comportements, F-37380, Nouzilly, France; Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 7247, F-37380, Nouzilly, France; Université de Tours, F-37041, Tours, France; Institut Français du Cheval et de l'équitation (IFCE), F-37380, Nouzilly, France.AbstractNeural stem and precursor cells persist postnatally throughout adulthood and are capable of responding to numerous endogenous and exogenous signals by modifying their proliferation and differentiation. Whereas adult neurogenesis has been extensively studied in the dentate gyrus of the hippocampal formation and in the subventricular zone adjacent to the wall of the lateral ventricles, we and others have recently reported constitutive adult neurogenesis in other brain structures, including the hypothalamus. In this study, we used immunohistochemistry to study the expression of the neuroblast marker doublecortin (DCX), and compared its expression pattern in adult ovine, mouse, and human hypothalamic tissues. Our results indicate that DCX-positive cells resembling immature and developing neurons occur in a wide range of hypothalamic nuclei in all three species, although with different distribution patterns. In addition, the morphology of DCX-positive cells varied depending on their location. DCX-positive cells near the third ventricle had the morphology of very immature neuroblasts, a round shape with no processes, whereas those located deeper in the parenchyma such as in the ventromedial nucleus were fusiform and showed a bipolar morphology. Extending this observation, we showed that among the cohort of immature neurons entering the ventromedial nucleus, some appeared to undergo maturation, as revealed by the partial colocalization of DCX with markers of more mature neurons, e.g., human neuronal protein C and D (HuC/D). This study provides further confirmation of the existence of an adult hypothalamic neurogenic niche and argues for the potential existence of a migratory path within the hypothalamus. J. Comp. Neurol. 522:1966-1985, 2014. © 2013 Wiley Periodicals, Inc.
The Journal of comparative neurology.J Comp Neurol.2014 Jun 1;522(8):1966-85. doi: 10.1002/cne.23514.
Neural stem and precursor cells persist postnatally throughout adulthood and are capable of responding to numerous endogenous and exogenous signals by modifying their proliferation and differentiation. Whereas adult neurogenesis has been extensively studied in the dentate gyrus of the hippocampal fo
PMID 24288185

Coarctation of the aorta in Noonan-like syndrome with loose anagen hair.

Zmolikova M1, Puchmajerova A, Hecht P, Lebl J, Trkova M, Krepelova A.Author information 1Department of Biology and Medical Genetics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.AbstractNoonan-like syndrome with loose anagen hair (NS/LAH; OMIM 607721) due to a missense mutation c.4A>G in SHOC2 predicting p.Ser2Gly has been described recently. This condition is characterized by facial features similar to Noonan syndrome, reduced growth, cardiac defects, and typical abnormal hair. We report on a patient with molecularly confirmed NS/LAH with coarctation of the aorta. The girl was precipitously born at 37 weeks of gestation at home and required a 3-min resuscitation. Increased nuchal translucency and aortic coarctation with a small ventricular septal defect were described prenatally, hypertrophic cardiomyopathy was detected postnatally. The patient presented with facial dysmorphism typical of NS with redundant skin over the nape and on the back. Short stature, relative macrocephaly, failure-to-thrive together with dystrophic appearance, developmental delay mainly in motor milestones and very thin, sparse, slow-growing hair occurred a few weeks after birth. Endocrine evaluation revealed low IGF-1 levels and borderline growth hormone deficiency. Growth hormone therapy started at 16 months had a partial effect and prevented further growth deterioration. Coarctation of the aorta is not a typical heart defect among individuals with NS/LAH, therefore our observation extends the phenotypic spectrum of this disorder. © 2014 Wiley Periodicals, Inc.
American journal of medical genetics. Part A.Am J Med Genet A.2014 May;164(5):1218-21. doi: 10.1002/ajmg.a.36404. Epub 2014 Jan 23.
Noonan-like syndrome with loose anagen hair (NS/LAH; OMIM 607721) due to a missense mutation c.4A>G in SHOC2 predicting p.Ser2Gly has been described recently. This condition is characterized by facial features similar to Noonan syndrome, reduced growth, cardiac defects, and typical abnormal hair.
PMID 24458596

Japanese Journal

左肺が無形成であった先天性左横隔膜ヘルニアの1症例

村上孟司,日高庸博,城戸咲,福嶋恒太郎,永田公二,田口智章,加藤聖子
超音波医学 advpub(0), 2015
先天性横隔膜ヘルニア胎児の肺低形成を超音波で評価するにあたって，肺胸郭断面積比（lung-to-thorax transverse ratio: LTR）や肺断面積児頭周囲長比（lung area to head circumference ratio: LHR）が用いられるが，これらの指標は健側肺がターゲットであり，患側肺は考慮しない．今回，胎児期に左横隔膜ヘルニアと診断，LTRやLHRは低値で …
NAID 130005063654

育児行動の促進を目的とした父親学級プログラムの介入時期別にみた効果の検討

山口咲奈枝,佐藤幸子
母性衛生 54(4), 504-511, 2014-01
【目的】育児行動を促進させるための独自に作成した父親学級プログラムを実施し,その効果と介入時期を検討する。【方法】平成24年2〜5月に, A病院の産前教室に参加した初めて子どもをもつ父親を産前に介入する群6名,産後に介入する群6名,非介入群5名に無作為に割りつけた。評価は産前,退院1週間後,退院1ヵ月後に行った。評価内容は育児・家事時間,性役割観,子ども観である。プログラムは「父親が育児をする意義 …
NAID 110009688136

A Case of Endoscopic Marsupialization for a Congenital Laryngeal Saccular Cyst

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耳鼻咽喉科臨床　補冊 138(0), 86-87, 2014
… A 7-month-old girl visited our hospital in whom stridor in the night had occurred from two weeks postnatally. …
NAID 130004834056