WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/13 16:47:46」(JST)

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Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.

Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units.^[1] In practice, a red light source emitting at 630 nm is used to excite the Porfimer oligomers.^[2]

Approvals and indications

It was approved in Canada in 1993 for the treatment of bladder cancer^[2]. It was approved in Japan in 1994 (for early stage lung cancer?)^[2]. It was approved by the U.S. FDA in December 1995 esophageal cancer, and in 1998, it was approved for the treatment of early non-small cell lung cancer^[2].

In August 2003 the FDA approved its use for Barrett's esophagus.^[3]

References

^ http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020451s019lbl.pdf
^ ^a ^b ^c ^d http://journals.lww.com/jto/Fulltext/2006/06000/Photodynamic_Therapy__PDT__for_Lung_Cancers.18.aspx "Photodynamic Therapy (PDT) for Lung Cancers" 2006
^ "FDA Patient Safety News: Show #20, October 2003". October 2003. http://www.accessdata.fda.gov/psn/printer-full.cfm?id=24. Retrieved 2009-08-17.

External links

Photofrin
Photofrin marketing info
Side effects of PDT with Photofrin
History of Photofrin

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UpToDate Contents

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1. 成人の気道疾患のマネージメントにおける気管支内光線力学的療法 endobronchial photodynamic therapy in the management of airway disease in adults
2. バレット食道：光線力学療法 barretts esophagus treatment with photodynamic therapy
3. Treatment of primary non-muscle invasive urothelial bladder cancer
4. 食道癌の内視鏡的緩和 endoscopic palliation of esophageal cancer
5. 光線過敏症（光線皮膚症）：臨床症状、診断、および治療 photosensitivity disorders photodermatoses clinical manifestations diagnosis and treatment

English Journal

Development of photodynamic therapy regimens that control primary tumor growth and inhibit secondary disease.

Shams M1, Owczarczak B, Manderscheid-Kern P, Bellnier DA, Gollnick SO.
Cancer immunology, immunotherapy : CII.Cancer Immunol Immunother.2015 Mar;64(3):287-97. doi: 10.1007/s00262-014-1633-9. Epub 2014 Nov 11.
Effective therapy for advanced cancer often requires treatment of both primary tumors and systemic disease that may not be apparent at initial diagnosis. Numerous studies have shown that stimulation of the host immune system can result in the generation of anti-tumor immune responses capable of cont
PMID 25384911

Evaluation of a novel high-resolution magnifying videoendoscope that is capable of photodynamic diagnosis and therapy for gastric cancer.

Nakamura T1, Oinuma T2, Yamagishi H3, Masuyama H4, Terano A5.
Photodiagnosis and photodynamic therapy.Photodiagnosis Photodyn Ther.2015 Mar;12(1):115-22. doi: 10.1016/j.pdpdt.2014.10.010. Epub 2014 Nov 20.
OBJECTIVE: To evaluate the usefulness of a novel high-resolution magnifying videoendoscope called the XG-0001 (Fujifilm, Tokyo, Japan) that is capable of PDD and PDT in experimental and clinical situations.MATERIALS AND METHODS: The fluorescences of three photosensitizers (i.e., porfimer sodium (Pho
PMID 25462577

Japanese Journal

脳腫瘍における光線力学診断と光線力学療法

黒岩敏彦
Neuro-Oncologyの進歩 21(3), 14-21, 2014
… Photodynamic diagnosis or photodynamic detection (PDD) is a method that uses various fluorescent dyes such as fluorescein sodium (FS), indocyanine green (ICG), 5-aminofluorescein-albumin conjugate, hematoporphyrin derivatives including porfimer sodium and 5-aminolevulinic acid (5-ALA), and mono-L-aspartyl chlorin e6 (Npe6). …
NAID 130005002159

Usefulness of Photodynamic Diagnosis and Therapy using Talaporfin Sodium for an Advanced-aged Patient with Inoperable Gastric Cancer (a secondary publication)

Nakamura Tetsuya,Oinuma Takeshi
LASER THERAPY 23(3), 201-210, 2014
… We report herein on the efficacy of palliative PDT using talaporfin sodium (Laserphyrin®) for a case of inoperable gastric cancer. … He was treated with 1 course of porfimer sodium PDT and 3 courses of talaporfin sodium PDT with photodynamic diagnosis (PDD) during the period from September, 2009 to June, 2011. … Conclusion: Talaporfin sodium PDT is safe and effective treatment for advanced-aged patients suffering from inoperable gastric cancer. …
NAID 130004697090

「ポルフィマー」

Porfimer sodium
Clinical data
AHFS/Drugs.com	Consumer Drug Information
Licence data	EMA:Link, US FDA:link
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Intravenous
Pharmacokinetic data
Bioavailability	NA
Protein binding	~90%
Half-life	21.5 days (mean)
Excretion	Fecal
Identifiers
CAS number	97067-70-4 87806-31-3
ATC code	L01XD01
PubChem	CID 57166
DrugBank	DB00707
ChemSpider	10482283
UNII	Y3834SIK5F
ChEMBL	CHEMBL1201707
Chemical data
Formula	C68H74N8O11 (for n=0)
Mol. mass	1179.36 g/mol (for n=0)
	SMILES [Na+].OC(=O)CC\C2=C(/C)c1cc%10nc(cc4nc(cc3nc(cc2n1)c(CCC(O)=O)c3C)/C(=C4/C)C(C)OC(C)c9c5nc(cc8nc(cc7nc(cc6nc(c5)C(\C)=C6\C(C)O)c(C)c7CCC(O)=O)C(\CCC(O)=O)=C8\C)c9C)c(C(C)O)c%10C;
	InChI InChI=1S/C68H74N8O11.Na/c1-29-41(13-17-61(79)80)53-28-56-44(16-20-64(85)86)32(4)48(72-56)24-59-68(36(8)52(76-59)25-58-65(37(9)77)33(5)49(73-58)21-45(29)69-53)40(12)87-39(11)67-35(7)50-22-46-30(2)42(14-18-62(81)82)54(70-46)27-55-43(15-19-63(83)84)31(3)47(71-55)23-57-66(38(10)78)34(6)51(74-57)26-60(67)75-50;/h21-28,37-40,71-73,75,77-78H,13-20H2,1-12H3,(H,79,80)(H,81,82)(H,83,84)(H,85,86);/q;+1/b45-21-,46-22-,47-23-,48-24-,49-21-,50-22-,51-26-,52-25-,53-28-,54-27-,55-27-,56-28-,57-23-,58-25-,59-24-,60-26-; ; Key:CGQHMICGJYKFFJ-ZLJVSRBASA-N ;
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