polysorbate

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polysorbate 80

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/08 00:32:14」(JST)

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Polysorbate 60, a compound used as a food additive in some pudding mixes to prevent scorching during preparation

Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids. Common brand names for Polysorbates include Alkest, Canarcel and Tween.

Safety

A study suggested that exposure to polysorbates was the cause of hypersensitive reactions in two patients.

Examples

• Polysorbate 20 (Polyoxyethylene (20) sorbitan monolaurate)
• Polysorbate 40 (Polyoxyethylene (20) sorbitan monopalmitate)
• Polysorbate 60 (Polyoxyethylene (20) sorbitan monostearate)
• Polysorbate 80 (Polyoxyethylene (20) sorbitan monooleate)

The number 20 following the polyoxyethylene part refers to the total number of oxyethylene -(CH₂CH₂O)- groups found in the molecule. The number following the polysorbate part is related to the type of fatty acid associated with the polyoxyethylene sorbitan part of the molecule. Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60 and monooleate by 80.

See also

• Sorbitan monolaurate
• Sorbitan monopalmitate
• Sorbitan monostearate
• Sorbitan tristearate
• Sorbitan monooleate

References

External links

• NIH PEG-60 (Polysorbate 60) Household Products Database

UpToDate Contents

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• 5. 全身化学療法に対する輸注反応 infusion reactions to systemic chemotherapy

English Journal

• Use of ferric thiocyanate derivatization for quantification of polysorbate 80 in high concentration protein formulations.

• Savjani N1, Babcock E1, Khor HK1, Raghani A2.
• Talanta.Talanta.2014 Dec;130:542-6. doi: 10.1016/j.talanta.2014.07.052. Epub 2014 Jul 29.
• Quantitation of polysorbate 80 in high protein formulation using solid-phase extraction (SPE) followed by derivatization with cobalt thiocyanate and UV measurement of the complex at 620nm resulted in lower recovery of polysorbate 80. Dilution of protein samples with water improved the recovery of po
• PMID 25159444

• Surface modified PLGA nanoparticles for brain targeting of Bacoside-A.

• Jose S1, Sowmya S2, Cinu TA3, Aleykutty NA2, Thomas S4, Souto EB5.
• European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2014 Oct 15;63:29-35. doi: 10.1016/j.ejps.2014.06.024. Epub 2014 Jul 8.
• The present paper focuses on the development and in vitro/in vivo characterization of nanoparticles composed of poly-(D,L)-Lactide-co-Glycolide (PLGA) loading Bacoside-A, as a new approach for the brain delivery of the neuroprotective drug for the treatment of neurodegenerative disorders (e.g. Alzhe
• PMID 25010261

• Self-micellizing solid dispersion of cyclosporine A with improved dissolution and oral bioavailability.

• Onoue S1, Suzuki H2, Kojo Y2, Matsunaga S2, Sato H2, Mizumoto T3, Yuminoki K4, Hashimoto N4, Yamada S2.
• European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2014 Oct 1;62:16-22. doi: 10.1016/j.ejps.2014.05.006. Epub 2014 May 14.
• The present study aimed to develop a self-micellizing solid dispersion (SMSD) of cyclosporine A (CsA) using an amphiphilic block copolymer, poly[MPC-co-BMA], to improve the biopharmaceutical properties of CsA. The cytotoxicity of poly[MPC-co-BMA] was assessed in rat intestinal IEC-6 cells, and the p
• PMID 24836392

Japanese Journal

• 医薬品溶出試験時に用いる界面活性剤の適正使用・保存安定性に関する研究

• 医薬品医療機器レギュラトリーサイエンス 46(3), 171-179, 2015
• NAID 40020389409

• Accurate Enumeration of <i>Aspergillus brasiliensis</i> in Hair Color and Mascara by Time-Lapse Shadow Image Analysis

• Biocontrol Science 20(4), 281-284, 2015
• NAID 130005116281

• Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles

• Biological and Pharmaceutical Bulletin 38(10), 1645-1648, 2015
• NAID 130005101583

Related Links

• ポリソルベート20、ポリソルベート60、ポリソルベート65及び ...

ポリソルベート20、ポリソルベート60、ポリソルベート65及びポリソルベ ート80の食品添加物の指定に関する添加物部会報告書（案） 1．品目名 ポリソルベート20 英名：Polyoxyethylene (20) Sorbitan Monolaurate、Polysorbate 20 その他 ...

• Ultra-pure Polysorbate 80

Ultra-Purity Polysorbate 80 provides features of low degranulation (Low Allergic Reaction), low Cell Toxicity and low Hemolysis and meets with multi-compendial USP, EP, JP. ... The product name has been changed from ...

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