English Journal

Regulation of the transient receptor potential channel TRPM3 by phosphoinositides.

Tóth BI1, Konrad M2, Ghosh D1, Mohr F2, Halaszovich CR2, Leitner MG2, Vriens J3, Oberwinkler J4, Voets T5.
The Journal of general physiology.J Gen Physiol.2015 Jul;146(1):51-63. doi: 10.1085/jgp.201411339.
The transient receptor potential (TRP) channel TRPM3 is a calcium-permeable cation channel activated by heat and by the neurosteroid pregnenolone sulfate (PregS). TRPM3 is highly expressed in sensory neurons, where it plays a key role in heat sensing and inflammatory hyperalgesia, and in pancreatic
PMID 26123194

Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion.

Hirst DJ1, Lee TH1, Pattenden LK1, Thomas WG2, Aguilar MI1.
Scientific reports.Sci Rep.2015 Jun 30;5:9972. doi: 10.1038/srep09972.
The carboxyl-terminus of the type 1 angiotensin II receptor (AT1A) regulates receptor activation/deactivation and the amphipathic Helix 8 within the carboxyl-terminus is a high affinity interaction motif for plasma membrane lipids. We have used dual polarisation interferometry (DPI) to examine the r
PMID 26126083

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-Gated Cav1.2 Calcium Channel Function.

Kaur G1, Pinggera A1, Ortner NJ1, Lieb A1, Sinnegger-Brauns MJ1, Yarov-Yarovoy V2, Obermair GJ1, Flucher BE1, Striessnig J3.
The Journal of biological chemistry.J Biol Chem.2015 Jun 22. pii: jbc.M115.645671. [Epub ahead of print]
L-type voltage-gated Ca2+-channels (LTCCs) regulate many physiological functions like muscle contraction, hormone secretion, gene expression and neuronal excitability. Their activity is strictly controlled by various molecular mechanisms. The pore-forming α1-subunit comprises four repeated domains
PMID 26100638

Japanese Journal

The Importance of Interaction with Membrane Lipids through the Pleckstrin Homology Domain of the Guanine Nucleotide Exchange Factor for Rho Family Small Guanosine Triphosphatase, FLJ00018

Kimura Shinji,Sato Katsuya,Banno Yoshiko [他],Nagase Takahiro,Ueda Hiroshi
Biological and Pharmaceutical Bulletin 36(7), 1204-1207, 2013
FLJ00018, a heterotrimeric guanosine 5′-triphosphate (GTP)-binding protein (G protein) Gβγ subunit-activated guanine nucleotide exchange factor for Rho family small GTPases, regulates cellular respons …
NAID 130003361463

Identification of a new polyphosphoinositide in plants, phosphatidylinositol 5-monophosphate (PtdIns5P), and its accumulation upon osmotic stress

Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release

Richard Chikara Koya,Fujita Hisakazu,Shimizu Shigeomi,Ohtsu Makoto,Takimoto Masato,Tsujimoto Yoshihide,Kuzumaki Noboru
Journal of Biological Chemistry 275(20), 15343-15349, 2000-05-19
… This protective function of gelsolin, which was not due to simple Ca2+ sequestration, was inhibited by polyphosphoinositide binding. …
NAID 120000960262