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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/01 17:02:48」(JST)

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"PHEMA" redirects here. For the Greek goddess, see Pheme.

Poly(2-hydroxyethyl methacrylate) (pHEMA) is a polymer that forms a hydrogel in water. It was invented by Drahoslav Lim and Otto Wichterle for biological use.^[1] Together they succeeded in preparing a cross-linking gel which absorbed up to 40% of water, exhibited suitable mechanical properties and was transparent. They patented this material in 1953.

Applications[edit]

On 1954 this material was first used as an optical implant. Wichterle thought pHEMA might be a suitable material for contact lenses and gained his first patent for soft contact lenses. By late 1961 he succeeded in producing the first four pHEMA hydrogel contact lenses on a home-made apparatus. Copolymers of pHEMA are still widely used today. Poly-HEMA functions as a hydrogel by rotating around its central carbon. In air, the non-polar methyl side turns outward, making the material brittle and easy to grind into the correct lens shape. In water, the polar hydroxyethyl side turns outward and the material becomes flexible. Pure pHEMA yields lenses that are too thick for sufficient oxygen to diffuse through, so all contact lenses that are pHEMA based are manufactured with copolymers that make the gel thinner and increase its water of hydration.^[2] These copolymer hydrogel lenses are often suffixed "-filcon", such as Methafilcon, which is a copolymer of hydroxyethyl methacrylate and methyl methacrylate.

References[edit]

^ Wichterle, O.; Lím, D. (9 January 1960). "Hydrophilic Gels for Biological Use". Nature 185 (4706): 117–118. doi:10.1038/185117a0. Retrieved 5 October 2011. Cite uses deprecated parameters (help)
^ Ratner, Buddy D. (2004). Biomaterials Science, An Introduction to Materials in Medicine. Elsevier Academic Press. ISBN 0-12-582463-7.

UpToDate Contents

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English Journal

The effect of octadecyl chain immobilization on the hemocompatibility of poly (2-hydroxyethyl methacrylate).

Fischer M, Baptista CP, Gonçalves IC, Ratner BD, Sperling C, Werner C, Martins CL, Barbosa MA.SourceMax Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Dresden, Germany.
Biomaterials.Biomaterials.2012 Nov;33(31):7677-85. doi: 10.1016/j.biomaterials.2012.07.007. Epub 2012 Jul 26.
Albumin-scavenging surfaces decorated with n-alkyl chains represent an established strategy for blood-contacting applications. To evaluate this concept, a set of poly (2-hydroxyethyl methacrylate) (pHEMA) films modified with different amounts of octadecyl isocyanate (C18) was investigated in an in v
PMID 22840226

Electroneutral silica-based hybrid monolith for hydrophilic interaction capillary electrochromatography.

Lin X, Wang X, Zhao T, Zheng Y, Liu S, Xie Z.SourceInstitute of Food Safety and Environmental Monitoring, Fuzhou University, Fuzhou 350108, China. xulin@fzu.edu.cn
Journal of chromatography. A.J Chromatogr A.2012 Oct 19;1260:174-82. doi: 10.1016/j.chroma.2012.08.053. Epub 2012 Aug 23.
A novel electroneutral and polar silica-based hybrid monolith was developed by an in situ copolymerization of 2-hydroxyethylmethacrylate (HEMA) and polyhedral oligomeric silsesquioxane methacryl substituted (POSS-MA), and successfully employed for hydrophilic interaction capillary electrochromatogra
PMID 22954745

「ポリヒドロキシエチルメタクリレート」

Polyhydroxyethylmethacrylate
	IUPAC name Poly(2-hydroxyethyl methacrylate)
	Other names PHEMA, Hydron
Identifiers
CAS number	25249-16-5
PubChem	24898472
Properties
Molecular formula	(C6H10O3)n
Molar mass	variable
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	Infobox references