ポリアミン酸化酵素
WordNet
- any of the enzymes that catalyze biological oxidation
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/15 14:47:07」(JST)
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polyamine oxidase |
Identifiers |
EC number |
1.5.3.11 |
CAS number |
294646-71-2 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
In enzymology, a polyamine oxidase (EC 1.5.3.11) is an enzyme that catalyzes the chemical reaction
- N1-acetylspermine + O2 + H2O N1-acetylspermidine + 3-aminopropanal + H2O2
The 3 substrates of this enzyme are N1-acetylspermine, O2, and H2O, whereas its 3 products are N1-acetylspermidine, 3-aminopropanal, and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N1-acetylspermidine:oxygen oxidoreductase (deaminating). This enzyme is also called 1-N-acetylspermidine:oxygen oxidoreductase (deaminating). It has 2 cofactors: FAD, and Iron.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1B37, 1H81, 1H82, 1H83, 1H84, 1H86, 1RSG, 1YY5, and 1Z6L.
References
- Bolkenius FN, Seiler N (1981). "Acetylderivatives as intermediates in polyamine catabolism". Int. J. Biochem. 13 (3): 287–292. doi:10.1016/0020-711X(81)90080-X. PMID 7215618.
- Holtta E (1983). "Polyamine oxidase (rat liver)". Methods Enzymol. Methods in Enzymology 94: 306–311. doi:10.1016/S0076-6879(83)94054-5. ISBN 978-0-12-181994-1. PMID 6621391.
UpToDate Contents
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English Journal
- Pacific oyster polyamine oxidase: a protein missing link in invertebrate evolution.
- Cervelli M1, Polticelli F, Angelucci E, Di Muzio E, Stano P, Mariottini P.
- Amino acids.Amino Acids.2015 May;47(5):949-61. doi: 10.1007/s00726-015-1924-2. Epub 2015 Feb 6.
- Polyamine oxidases catalyse the oxidation of polyamines and acetylpolyamines and are responsible for the polyamine interconversion metabolism in animal cells. Polyamine oxidases from yeast can oxidize spermine, N (1)-acetylspermine, and N (1)-acetylspermidine, while in vertebrates two different enzy
- PMID 25655384
- Induced resistance by oxidative shifts in pigeonpea (Cajanus cajan L.) following Helicoverpa armigera (Hübner) herbivory.
- Kaur R1, Gupta AK, Taggar GK.
- Pest management science.Pest Manag Sci.2015 May;71(5):770-82. doi: 10.1002/ps.3851. Epub 2014 Jul 25.
- BACKGROUND: Oxidative responses in leaves, developing seeds and the pod wall of nine pigeonpea genotypes were investigated against Helicoverpa armigera feeding. Out of nine genotypes, four were moderately resistant, three were intermediate and two were moderately susceptible genotypes.RESULTS: A sig
- PMID 24974811
- Application of γ-aminobutyric acid demonstrates a protective role of polyamine and GABA metabolism in muskmelon seedlings under Ca(NO3)2 stress.
- Hu X1, Xu Z2, Xu W2, Li J2, Zhao N2, Zhou Y2.
- Plant physiology and biochemistry : PPB / Societe francaise de physiologie vegetale.Plant Physiol Biochem.2015 Apr 11;92:1-10. doi: 10.1016/j.plaphy.2015.04.006. [Epub ahead of print]
- The effects of exogenous γ-aminobutyric acid (GABA) application on growth, polyamine and endogenous GABA metabolism in muskmelon leaves and roots were measured. Plants were treated under control or 80 mM Ca(NO3)2 stress conditions with or without foliar spraying 50 mM GABA. Ca(NO3)2 stress signif
- PMID 25885476
Japanese Journal
- Polyamine Oxidase 7 is a Terminal Catabolism-Type Enzyme in Oryza sativa and is Specifically Expressed in Anthers
- Liu Taibo,Kim Dong Wook,Niitsu Masaru [他]
- Plant and cell physiology 55(6), 1110-1122, 2014-06
- NAID 40020095909
- Evaluation of Alfalfa and Oat Polyamine Oxidase: One-Step Purification and Characteristics
- Sakakibara Yoko
- 愛知教育大学研究報告. 自然科学編 63, 53-58, 2014-03-01
- … The polyamine oxidase activity of acetone powder from alfalfa was investigated. … Oat polyamine oxidase was purified in one step isoelectric point chromatography. …
- NAID 120005412180
- Development of Irreversible Inactivators of Spermine Oxidase and N¹-Acetylpolyamine Oxidase
- Moriya Shun-suke,Miura Toshiyuki,Takao Koichi [他],Sugita Yoshiaki,Samejima Keijiro,Hiramatsu Kyoko,Kawakita Masao
- Biological and Pharmaceutical Bulletin 37(3), 475-480, 2014
- … Of the six compounds synthesized, N-(3-aminopropyl)-N′-2,3-butadienyl-1,4-butanediamine (N8-butadienyl Spd) and N-[3-(2,3-butadienylamino)propyl]-1,4-butanediamine (N1-butadienyl Spd) irreversibly inactivated human spermine oxidase (SMO) and N1-acetylpolyamine oxidase (APAO). …
- NAID 130003390953
Related Links
- Definition of polyamine oxidase in the Medical Dictionary. polyamine oxidase explanation. Information about polyamine oxidase in Free online English dictionary. What is polyamine oxidase? Meaning of polyamine oxidase medical ...
- 1. Prog Brain Res. 1995;106:333-44. Polyamine oxidase, properties and functions. Seiler N. Laboratoire de Biologie Cellulaire, Faculté de Médecine, Université de Rennes, France. Polyamine oxidase (PAO) is a FAD-dependent ...
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- polyamine oxidase PAO
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