WordNet
- (biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription
- an inactive form of plasmin that occurs in plasma and is converted to plasmin by organic solvents
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/27 11:15:57」(JST)
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- 1. Overview of hemostasis
- 2. 血栓溶解異常による血栓性および出血性疾患 thrombotic and hemorrhagic disorders due to abnormal fibrinolysis
- 3. 血管内皮機能および血栓溶解療法の基本的メカニズム vascular endothelial function and fundamental mechanisms of fibrinolysis thrombolysis
- 4. 線溶マーカーおよび心血管リスク fibrinolytic markers and cardiovascular risk
- 5. ST上昇型心筋梗塞における血栓溶解療法の特性および臨床試験 characteristics of fibrinolytic thrombolytic agents and clinical trials in acute st elevation myocardial infarction
English Journal
- Resolution of Skin Fibrosis by Neutralization of the Antifibrinolytic Function of Plasminogen Activator Inhibitor 1.
- Lemaire R1, Burwell T2, Sun H2, Delaney T2, Bakken J2, Cheng L2, Rebelatto MC2, Czapiga M2, de-Mendez I3, Coyle AJ2, Herbst R2, Lafyatis R4, Connor J2.
- Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2016 Feb;68(2):473-83. doi: 10.1002/art.39443.
- OBJECTIVE: Systemic sclerosis (SSc) is a fibrotic disease characterized by an obliterative vasculopathy with thrombosis and impairment of the coagulation-fibrinolysis balance. Plasminogen activator inhibitor 1 (PAI-1) is the major inhibitor of profibrinolytic plasminogen activators (PAs). This study
- PMID 26414805
- Tissue and urokinase plasminogen activators instigate the degeneration of retinal ganglion cells in a mouse model of glaucoma.
- Chintala SK1.
- Experimental eye research.Exp Eye Res.2016 Feb;143:17-27. doi: 10.1016/j.exer.2015.10.003. Epub 2015 Oct 22.
- Elevated intraocular pressure (IOP) promotes the degeneration of retinal ganglion cells (RGCs) during the progression of Primary Open-Angle Glaucoma (POAG). However, the molecular mechanisms underpinning IOP-mediated degeneration of RGCs remain unclear. Therefore, by employing a mouse model of POAG,
- PMID 26474495
- Distinct encounter complexes of PAI-1 with plasminogen activators and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop.
- Qureshi T1, Goswami S1, McClintock CS1, Ramsey MT1, Peterson CB1.
- Protein science : a publication of the Protein Society.Protein Sci.2016 Feb;25(2):499-510. doi: 10.1002/pro.2841. Epub 2015 Dec 2.
- Plasminogen activator inhibitor-1 (PAI-1) is a biologically important serine protease inhibitor (serpin) that, when overexpressed, is associated with a high risk for cardiovascular disease and cancer metastasis. Several of its ligands, including vitronectin, tissue-type and urokinase-type plasminoge
- PMID 26548921
Japanese Journal
- ヒト胎盤形成におけるプロテアーゼ系の寄与
- Reproductive Immunology and Biology 30(0), 7-12, 2015
- NAID 130005161656
- 血栓溶解機構とその制御 (特集 血栓・塞栓症 : 治療・予防の最新動向) -- (基礎研究の進歩)
- 日本臨床 72(7), 1218-1223, 2014-07
- NAID 40020130981
- Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid.
- PloS one 9(1), 2014-01-21
- NAID 120005512260
Related Links
- 1. Adv Cancer Res. 1985;44:139-266. Plasminogen activators, tissue degradation, and cancer. Danø K, Andreasen PA, Grøndahl-Hansen J, Kristensen P, Nielsen LS, Skriver L. PMID: 2930999 [PubMed - indexed for MEDLINE]
- Rijken DC (1988). "Relationships between structure and function of tissue-type plasminogen activator". Klin. Wochenschr. 66 Suppl 12: 33–9. PMID 3126346. Bode W, Renatus M (1997). "Tissue-type plasminogen activator: variants ...
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