関: pirlimycin hydrochloride hydrate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/05 20:16:31」(JST)

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Pirlimycin hydrochloride belongs to the lincosamide class of antimicrobials. Under the trade name Pirsue,^[1] it is used in the treatment of mastitis in cattle.

Activity[edit]

Pirlimycin is active against Gram-positive bacteria, specifically Staphylococcus aureus and coagulase negative species of Staphylococcus and Streptococcus. It has no activity against Gram-negative bacteria.^[2]

Mechanism of action[edit]

It is bacteriostatic and acts by inhibiting bacterial protein synthesis via binding with the 50S subunit of the ribosome.

References[edit]

^ Pirsue Sterile Solution
^ USP: Pirlimycin

This systemic antibacterial-related article is a stub. You can help Wikipedia by expanding it.

English Journal

Analysis of Pirlimycin Residues in Beef Muscle, Milk, and Honey by a Biotin-Streptavidin-Amplified Enzyme-Linked Immunosorbent Assay.

Jiang W1, Beier RC2, Luo P3, Zhai P1, Wu N3, Lin G1, Wang X1, Xu G4.
Journal of agricultural and food chemistry.J Agric Food Chem.2016 Jan 13;64(1):364-70. doi: 10.1021/acs.jafc.5b05711. Epub 2015 Dec 31.
Food contamination by veterinary drug residues is a worldwide public health concern and requires continuous monitoring. In this study, we developed a biotin-streptavidin-amplified ELISA (BA-ELISA) using a produced monoclonal antibody for detecting pirlimycin residues in beef muscle, milk, and honey.
PMID 26671277

Phenotypic antimicrobial susceptibility and occurrence of selected resistance genes in gram-positive mastitis pathogens isolated from Wisconsin dairy cows.

Ruegg PL1, Oliveira L2, Jin W3, Okwumabua O4.
Journal of dairy science.J Dairy Sci.2015 Jul;98(7):4521-34. doi: 10.3168/jds.2014-9137. Epub 2015 Apr 23.
In the United States, few intramammary antimicrobials exist that are approved for treatment of bovine mastitis; thus, ensuring judicious use of these products is a priority. The objectives of this study were to determine phenotypic susceptibility and presence of selected antimicrobial resistance gen
PMID 25912858

Method development and validation: solid Phase extraction-ultra performance liquid chromatography-tandem mass spectrometry quantification of pirlimycin in bovine feces and urine.

Ray P, Knowlton KF, Shang C, Xia K.
Journal of AOAC International.J AOAC Int.2014 Nov-Dec;97(6):1730-6.
Pirlimycin, a lincosamide antibiotic, is one of the most commonly used antibiotics for the treatment of mastitis in dairy cows. Assessment of pirlimycin loadingto the environment via fecal and urinary excretion is critical to develop efficient management strategies to reduce environmental pollution
PMID 25632451

Japanese Journal

Identification and determination of pirlimycin residue in bovine milk and liver by high-performance liquid chromatography-thermospray mass spectrometry

HORNISH Rex E.,CAZERS Alex R.,CHESTER S. Theodore Jr.,ROOF Ryan D.
Journal of chromatography. B, Biomedical applications 674(2), 219-235, 1995-12-15
NAID 10024551579

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「ピルリマイシン」

Pirlimycin
Systematic (IUPAC) name
	Methyl(2S-cis)-7-chloro-6,7,8-trideoxy-6[[(4-ethyl-2-piperidinyl) carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Intramammary
Identifiers
CAS number	79548-73-5
ATCvet code	QJ51FF90
UNII	LM19JT6G5K
KEGG	D08391
ChEMBL	CHEMBL1652611
Chemical data
Formula	C17H31ClN2O5S
Mol. mass	410.164 g/mol
	SMILES N2CCC(CC)CC2C(=O)NC(C(C)Cl)C(C(O)C1O)OC(SC)C1O;
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