関: pipazethate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/21 23:34:23」(JST)

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Pipazetate (or pipazethate) is a cough suppressant.

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English Journal

Spectrophotometric Determination of Pipazethate HCl and Dextromethorphan HBr using Potassium Permanganate.

Gouda AA, El-Sheikh R, El Shafey Z, Hossny N, El-Azzazy R.Author information Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt;AbstractRapid, simple and sensitive validated spectrophotometric methods have been described for the assay of pipazethate HCl (PiCl) and dextromethorphan HBr (DEX) either in pure form or in pharmaceutical formulations. The proposed methods were based on the oxidation of the studied drugs by a known excess of potassium permanganate in acidic medium and estimating the unreacted permanganate with amaranth dye (method A), acid orange II (method B), indigocarmine (method C) and methylene blue (method D), in the same acid medium at a suitable λmax=521, 485, 610 and 664 nm, respectively. Beer's law is obeyed in the concentration range of 2.0-16 and 2.0-15 μg mL(-1) for PiCl and DEX, respectively with correlation coefficient (n=6) ≥ 0.9993. The apparent molar absorptivity and sandell sensitivity values are in the range 1.062-1.484 × 10(4), 3.35-4.51 × 10(4) L mol(-1) cm(-1) and 29.36-41.03, 8.21-11.06 ng cm(-2) for PiCl and DEX, respectively. Different variables affecting the reaction were studied and optimized. The proposed methods were applied successfully to the determination of the examined drugs either in a pure or pharmaceutical dosage forms with good accuracy and precision. No interferences were observed from excipients and the results obtained were in good agreement with those obtained using the official methods.
International journal of biomedical science : IJBS.Int J Biomed Sci.2008 Dec;4(4):294-302.
Rapid, simple and sensitive validated spectrophotometric methods have been described for the assay of pipazethate HCl (PiCl) and dextromethorphan HBr (DEX) either in pure form or in pharmaceutical formulations. The proposed methods were based on the oxidation of the studied drugs by a known excess o
PMID 23675101

Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations.

Amin AS, El-Sheikh R, Zahran F, Gouda AA.Author information Chemistry Department, Faculty of Science, Benha University, Benha, Egypt.AbstractA simple, accurate and highly sensitive spectrophotometric method is proposed for the rapid determination of pipazethate hydrochloride, dextromethorphan hydrobromide and drotaverine hydrochloride using chromotrope 2B (C2B) and chromotrope 2R (C2R). The method consists of extracting the formed ion-associates into chloroform in the case of pipazethate HCl and dextromethorphan HBr or into methylene chloride in the case of drotaverine HCl. The ion-associates exhibit absorption maxima at 528, 540 and 532 nm with C2B and at 526, 517 and 522 nm with C2R for pipazethate HCl, dextromethorphan HBr and drotaverine HCl, respectively. The calibration curves resulting from the measurements of absorbance-concentration relations (at the optimum reaction conditions) of the extracted ion-pairs are linear over the concentration range 4.36-52.32 microg mL(-1) for pipazethate, 3.7-48.15 microg mL(-1) for dextromethorphan and 4.34-60.76 microg mL(-1) for drotaverine, respectively. The effect of acidity, reagent concentration, time, solvent and stoichiometric ratio of the ion-associates were estimated. The molar absorptivity and Sandell sensitivity of the reaction products were calculated. Statistical treatment of the results reflects that the procedure is precise, accurate and easily applied for the determination of the drugs under investigation in pure form and in their pharmaceutical preparations.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2007 Jul;67(3-4):1088-93. Epub 2006 Sep 28.
A simple, accurate and highly sensitive spectrophotometric method is proposed for the rapid determination of pipazethate hydrochloride, dextromethorphan hydrobromide and drotaverine hydrochloride using chromotrope 2B (C2B) and chromotrope 2R (C2R). The method consists of extracting the formed ion-as
PMID 17092767

Spectrophotometric determination of pipazethate hydrochloride in pure form and in pharmaceutical formulations.

El-Shiekh R, Amin AS, Zahran F, Gouda AA.Author information Zagazig University, Faculty of Science, Chemistry Department, Zagazig, Egypt.AbstractThree simple, sensitive, and reproducible spectrophotometric methods (A-C) for the determination of pipazethate hydrochloride (PiCl) in pure form and in pharmaceutical formulations are described. The first and second methods, A and B, are based on the oxidation of the drug by Fe3+ in the presence of o-phenanthroline (o-phen) or bipyridyl (bipy). The formation of tris-complex upon reactions with Fe3+-o-phen and/or Fe3+-bipy mixture in an acetate buffer solution of the optimum pH values was demonstrated at 510 and 522 nm, respectively, with o-phen and bipy. The third method, C, is based on the reduction of Fe(III) by PiCl in acid medium and subsequent interaction of Fe(II) with ferricyanide to form Prussian blue, which exhibits an absorption maximum at 750 nm. The concentration ranges are from 0.5 to 8, 2 to 16, and 3 to 15 microg/mL for Methods A-C, respectively. For more accurate analysis, Ringbom optimum concentration ranges were calculated. The molar absorptivity, Sandell sensitivity, and detection and quantitation limits were calculated. The developed methods were successfully applied to the determination of PiCl in bulk and pharmaceutical formulations without any interference from common excipients. The relative standard deviations were < or =0.83% with recoveries of 98.9-101.15%.
Journal of AOAC International.J AOAC Int.2007 May-Jun;90(3):686-92.
Three simple, sensitive, and reproducible spectrophotometric methods (A-C) for the determination of pipazethate hydrochloride (PiCl) in pure form and in pharmaceutical formulations are described. The first and second methods, A and B, are based on the oxidation of the drug by Fe3+ in the presence of
PMID 17580620

「pipazethate」

Pipazethate
Systematic (IUPAC) name
	2-(2-piperidin-1-ylethoxy)ethyl 10H-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	2167-85-3
ATC code	R05DB11
PubChem	CID: 22425
DrugBank	DB08796
ChemSpider	21046
UNII	M5EK1T5V2L
KEGG	D05484
Chemical data
Formula	C21H25N3O3S
Molecular mass	399.508 g/mol
	SMILES O=C(OCCOCCN1CCCCC1)N3c4c(Sc2c3nccc2)cccc4 ;
	InChI InChI=1S/C21H25N3O3S/c25-21(27-16-15-26-14-13-23-11-4-1-5-12-23)24-17-7-2-3-8-18(17)28-19-9-6-10-22-20(19)24/h2-3,6-10H,1,4-5,11-16H2 ; Key:DTVJXCOMJLLMAK-UHFFFAOYSA-N ;
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