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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/22 19:36:49」(JST)
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Pinacidil |
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IUPAC name
N-cyano-N'-pyridin-4-yl-N''-(1,2,2-trimethylpropyl)guanidine
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Identifiers |
CAS number |
85371-64-8 N |
PubChem |
4826 |
ChEMBL |
CHEMBL1159 N, CHEMBL1200338 |
IUPHAR ligand |
2412 |
ATC code |
C02DG01 |
Jmol-3D images |
Image 1 |
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CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1
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Properties |
Molecular formula |
C13H19N5 |
Molar mass |
245.32346 |
N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
Infobox references |
Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.[1] It reduces blood pressure and peripheral resistance and produces fluid retention.[2]
References[edit]
- ^ Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H (1995). "Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells". J. Pharmacol. Exp. Ther. 275 (2): 681–92. PMID 7473155.
- ^ Reynolds, James Blair; Martindale, William L. (1996). The extra pharmacopoeia (31st ed.). London: Royal Pharmaceutical Society. pp. 2739 pages. ISBN 0-85369-342-0.
External links[edit]
- Pinacidil at the US National Library of Medicine Medical Subject Headings (MeSH)
Channel openers
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Potassium |
- Cromakalim
- Diazoxide
- Flupirtine
- Minoxidil
- Nicorandil
- Pinacidil
- Retigabine
- Rottlerin
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UpToDate Contents
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English Journal
- Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells.
- Kim D, Kim I, Papreck JR, Donnelly DF, Carroll JL.SourceDepartment of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, United States.
- Respiratory physiology & neurobiology.Respir Physiol Neurobiol.2011 Aug 15;177(3):247-55. Epub 2011 Apr 22.
- Carotid body glomus (CB) cells express different types of K(+) channels such as TASK, BK, and Kv channels, and hypoxia has been shown to inhibit these channels. Here we report the presence of a ?72-pS channel that has not been described previously in CB cells. In cell-attached patches with 150mM K
- PMID 21536154
- Effects of K(ATP) channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
- Fedorov VV, Glukhov AV, Ambrosi CM, Kostecki G, Chang R, Janks D, Schuessler RB, Moazami N, Nichols CG, Efimov IR.SourceDepartment of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
- Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2011 Aug;51(2):215-25. Epub 2011 May 7.
- This study compared the effects of ATP-regulated potassium channel (K(ATP)) openers, diazoxide and pinacidil, on diseased and normal human atria and ventricles. We optically mapped the endocardium of coronary-perfused right (n=11) or left (n=2) posterior atrial-ventricular free wall preparations fro
- PMID 21586291
Japanese Journal
- Effects of Nicorandil on the cAMP-Dependent Cl? Current in Guinea-Pig Ventricular Cells
- Nishimura Nami,Reien Yoshie,Matsumoto Akio,Ogura Takehiko,Miyata Yuuichi,Suzuki Kazumasa,Nakazato Yuji,Daida Hiroyuki,Nakaya Haruaki
- Journal of Pharmacological Sciences advpub(0), 1003170361, 2010
- … The isoproterenol-induced ICl,cAMP was inhibited by 100 μM glibenclamide, but not by 100 μM pinacidil. …
- NAID 130000253381
- Effects of Imatinib Mesylate in Interstitial Cells of Cajal from Murine Small Intestine
- Kim Byung Joo,Chae Han,Kwon Young Kyu,Choi Seok,Jun Jae Yeol,Jeon Ju-Hong,So Insuk,Kim Seon Jeong
- Biological & Pharmaceutical Bulletin 33(6), 993-997, 2010
- … Because the effects of imatinib on pacemaker potentials were the same as those of pinacidil, we examined the effect of glibenclamide on ICC exposed to imatinib. …
- NAID 130000247967
Related Links
- Buy Pinacidil (CAS 85371-64-8), a K+ channel activator, from Santa Cruz. Purity ≥99%, Molecular Formula C13H19N5•H2O, Molecular Weight 263.3 ... Pinacidil is a K + channel opener. Pinacidil is demonstrated to induce relaxation ...
- Species, Scientific Experts, Genomes and Genes, Research Grants, Publications, Research Topics about pinacidil ... Summary: A potassium-channel opener that produces direct peripheral vasodilatation of the arterioles. It reduces ...
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