HPLC method development, validation, and impurity characterization of a potent antitumor indenoisoquinoline, LMP776 (NSC 725776).
Wang J1, Liu M2, Yang C2, Wu X2, Wang E2, Liu P3.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 May 30;124:267-73. doi: 10.1016/j.jpba.2016.02.036. Epub 2016 Feb 27.
An HPLC method for the assay of a DNA topoisomerase inhibitor, LMP776 (NSC 725776), has been developed and validated. The stress testing of LMP776 was carried out in accordance with International Conference on Harmonization (ICH) guidelines Q1A (R2) under acidic, alkaline, oxidative, thermolytic, an
Photodegradation of diphenylarsinic acid by UV-C light: Implication for its remediation.
Wang A1, Teng Y1, Hu X2, Wu L1, Huang Y1, Luo Y3, Christie P1.
Journal of hazardous materials.J Hazard Mater.2016 May 5;308:199-207. doi: 10.1016/j.jhazmat.2016.01.049. Epub 2016 Jan 22.
Diphenylarsinic acid (DPAA) is a major contaminant in environments polluted by chemical weapons and abandoned after World Wars I and II and poses high risks to biota but remediation methods for this contaminant are rare. Here, the photodegradtion of DPAA was studied under high-pressure Hg lamp irrad
Photochemical transformation of five novel brominated flame retardants: Kinetics and photoproducts.
Zhang YN1, Chen J2, Xie Q1, Li Y1, Zhou C1.
Chemosphere.Chemosphere.2016 May;150:453-60. doi: 10.1016/j.chemosphere.2015.12.125. Epub 2016 Jan 12.
Many novel brominated flame retardants (NBFRs) are used as substitutes of polybrominated diphenyl ethers (PBDEs) in recent years. However, little is known about their phototransformation behavior, which may influence the environmental fate of these chemicals. In this study, photochemical behavior of
… Photolytic and sonophotolytic estriol degradation rate also were high at shortest UV wavelength (VUV) due to the higher energy of photons, higher molar absorption coefficient of estriol and increased hydroxyl radical generation from the homolysis of water. …
pho·tol·y·sis (fō-tŏl′ĭ-sĭs) n. Chemical decomposition induced by light or other radiant energy. pho′to·lyt′ic (fō′tə-lĭt′ĭk) adj. ... 2010 MATTIELLO MEMORIAL LECTURE--Degradation modes of crosslinked coatings exposed to photolytic ...