The Journal of biological chemistry.J Biol Chem.2016 Jan 22;291(4):1921-32. doi: 10.1074/jbc.M115.691725. Epub 2015 Dec 1.
Increasing antibacterial resistance presents a major challenge in antibiotic discovery. One attractive target in Gram-negative bacteria is the unique asymmetric outer membrane (OM), which acts as a permeability barrier that protects the cell from external stresses, such as the presence of antibiotic
3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability.
Kumar AB1, Tipton JD2, Manetsch R1.
Chemical communications (Cambridge, England).Chem Commun (Camb).2016 Jan 13. [Epub ahead of print]
Ambient light stable 3-trifluoromethyl-3-aryldiazirine photolabels are developed via stabilization of the strained three membered diazirine ring by replacing the phenyl ring with electron withdrawing heterocyclic rings. Photolabeling studies reveal that these ambient light stable photolabels are equ
Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels.
Kinde MN1, Bu W, Chen Q, Xu Y, Eckenhoff RG, Tang P.
Anesthesiology.Anesthesiology.2016 Jan 12. [Epub ahead of print]
BACKGROUND: Identifying functionally relevant anesthetic-binding sites in pentameric ligand-gated ion channels (pLGICs) is an important step toward understanding the molecular mechanisms underlying anesthetic action. The anesthetic propofol is known to inhibit cation-conducting pLGICs, including a p
Photoaffinity Labeling of Sialidase with a Biotin-Conjugated Phenylaminodiazirine Derivative of 2,3-Didehydro-2-deoxy-N-acetylneuraminic Acid(Biochemistry)
photolabeling (noun) · photolabel (transitive verb). photolabeling. noun. Definition of PHOTOLABELING. : photoaffinity labeling. Variants of PHOTOLABELING. photolabeling or photolabelling. Test Your Vocabulary. Take Our 10-Question Quiz ...
Photo labeling and crosslinking refer to a variety of methods developed over the past ... photolabeling and cross linking almost always lead to a complex pattern of ... In most applications of photolabeling and crosslinking reagents, the chemical ...