- 同
- PtdIns(3,4)P2, PIP2
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/27 22:17:20」(JST)
[Wiki en表示]
Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol (3,4)-bisphosphate
Phosphatidylinositol (3,4)-bisphosphate (PtdIns(3,4)P2) is a minor phospholipid component of cell membranes, yet an important second messenger. The generation of PtdIns(3,4)P2 at the plasma membrane activates a number of important cell signaling pathways.[1]
PtdIns(3,4)P2 is dephophosphorylated by the phosphatase INPP4B on the 4 position of the inositol ring and by the TPTE (transmembrane phosphatases with tensin homology) family of phosphatases on the 3 position of the inositol ring.
The PH domain in a number of proteins binds to PtdIns(3,4)P2 including the PH domain in PKB. The generation of PtdIns(3,4)P2 at the plasma membrane upon the activation of class I PI 3-kinases and SHIP phosphatases causes these proteins to translocate to the plasma membrane, thereby affecting their activity.
References
- ^ Dimitrios Karathanassis, Robert V. Stahelin, Jerónimo Bravo, Olga Perisic, Christine M Pacold, Wonhwa Cho and Roger L Williams (2002). "Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction". EMBO Journal 21 (19): 5057–5068. doi:10.1093/emboj/cdf519. PMC 129041. PMID 12356722.
Lipids: phospholipids
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Glycerol backbone
(Glycerophospholipids/
Phosphoglycerides) |
Phosphatidyl-: |
- -ethanolamine/cephalin (PE)
- -choline/lecithin (PC)
- -serine (PS)
- -glycerol (PG)
- -inositol (PI)
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Phosphoinositides: |
- PIP PI(3)P
- PIP2 (PI(3,4)P2
- PIP3
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Ether lipids: |
- Plasmalogen
- Platelet-activating factor
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Sphingosine backbone |
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Metabolites |
- Inositol phosphate
- Inositol
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- Choline
- Phosphocholine
- Citicoline
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UpToDate Contents
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English Journal
- Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence.
- Keum D1, Kruse M2, Kim DI1, Hille B3, Suh BC3.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2016 Jun 28;113(26):E3686-95. doi: 10.1073/pnas.1606472113. Epub 2016 May 24.
- Voltage-sensing phosphatases (VSPs) are homologs of phosphatase and tensin homolog (PTEN), a phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] 3-phosphatase. However, VSPs have a wider range of substrates, cleaving 3-phosphate from PI(3,4)P2
- PMID 27222577
- Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods.
- He F1, Agosto MA1, Anastassov IA1, Tse DY2,3, Wu SM2, Wensel TG1,2.
- Scientific reports.Sci Rep.2016 Jun 1;6:26978. doi: 10.1038/srep26978.
- Phosphoinositides play important roles in numerous intracellular membrane pathways. Little is known about the regulation or function of these lipids in rod photoreceptor cells, which have highly active membrane dynamics. Using new assays with femtomole sensitivity, we determined that whereas levels
- PMID 27245220
- Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1.
- Pastor-Flores D1, Schulze JO1, Bahí A2, Süß E1, Casamayor A3, Biondi RM4.
- Biochimica et biophysica acta.Biochim Biophys Acta.2016 Mar;1861(3):249-59. doi: 10.1016/j.bbalip.2015.12.016. Epub 2015 Dec 29.
- Pkh is the yeast ortholog of the mammalian 3-phosphoinositide-dependent protein kinase 1 (PDK1). Pkh phosphorylates the activation loop of Ypks, Tpks, Sch9 and also phosphorylates the eisosome components Lsp1 and Pil1, which play fundamental roles upstream of diverse signaling pathways, including th
- PMID 26743850
Japanese Journal
- The Importance of Interaction with Membrane Lipids through the Pleckstrin Homology Domain of the Guanine Nucleotide Exchange Factor for Rho Family Small Guanosine Triphosphatase, FLJ00018
- Parotid Secretory Protein Binds Phosphatidylinositol (3,4) Bisphosphate
- Visualization of Phosphoinositides via the Development of the Transient Expression System of a Cyan Fluorescent Protein in the Red Alga Porphyra yezoensis
Related Links
- Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is one of the seven phosphoinositides found in eukaryotic cell membranes. [1] In quiescent cells, the PtdIns(3,5)P2 levels, typically quantified by HPLC, are the lowest amongst ...
- Phosphatidylinositol (3,4)-bisphosphate (PtdIns(3,4)P2) is a minor phospholipid component of cell membranes, yet an important second messenger. The generation of PtdIns(3,4)P2 at the plasma membrane activates a number of ...
★リンクテーブル★
[★]
二リン酸エステル、二リン酸
- 関
- diphosphate、diphosphoric acid、pyrophosphate
[★]
ホスファチジルイノシトール