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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/08/12 22:02:53」(JST)
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Phlegmasia alba dolens |
Classification and external resources |
ICD-10 |
I80.1 |
ICD-9 |
451.11 |
DiseasesDB |
32484 |
Phlegmasia alba dolens (also colloquially known as milk leg or white leg) is part of a spectrum of diseases related to deep vein thrombosis. Historically, it was commonly seen during pregnancy and in mothers who have just given birth. In cases of pregnancy, it is most often seen during the third trimester, resulting from a compression of the left common iliac vein against the pelvic rim by the enlarged uterus. Today, this disease is most commonly (40% of the time) related to some form of underlying malignancy. Hypercoagulability (a propensity to clot formation) is a well-known state that occurs in many cancer states.
The disease presumably begins with a deep vein thrombosis that progresses to total occlusion of the deep venous system. It is at this stage that it is called phlegmasia alba dolens. It is a sudden (acute) process. The leg, then, must rely on the superficial venous system for drainage. The superficial system is not adequate to handle the large volume of blood being delivered to the leg via the arterial system. The result is edema, pain and a white appearance (alba) of the leg. The next step in the disease progression is occlusion of the superficial venous system, thereby preventing all venous outflow from the extremity. At this stage it is called phlegmasia cerulea dolens. The leg becomes more swollen and increasingly more painful. Additionally, the edema and loss of venous outflow impedes the arterial inflow. Ischemia and, hence, gangrene are the ultimate dreaded consequence.
Phlegmasia alba dolens is distinguished, clinically, from phlegmasia cerulea dolens in that there is no ischemia.[1]
"Phlegmasia alba dolens" literally means "painful white edema".[2] It received the name "milk leg" because it was once thought to be caused by the metastasis of milk.[3]
The incidence of this disease is not well reported.
References
- ^ Gregoire, R. La Phlebite bleue (Phlegmasia Cerulea Dolens). 1938;48:1313-15.
- ^ Dieulafoy, Paul Georges (1912). A Text-book of Medicine. D. Appleton & Co.. pp. 488. http://books.google.com/books?id=r_MRAAAAYAAJ.
- ^ Wright, Adam Henry (1905). A Text-book of Obstetrics. D. Appleton & Co.. pp. 473. http://books.google.com/books?id=T0ZEJ1dljhUC.
UpToDate Contents
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English Journal
- Relationships of HLA-B51 or B5 genotype with Behcet's disease clinical characteristics: systematic review and meta-analyses of observational studies.
- Maldini C, Lavalley MP, Cheminant M, de Menthon M, Mahr A.SourceDepartment of Internal Medicine, Hospital Saint-Louis, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. alfred.mahr@sls.aphp.fr.
- Rheumatology (Oxford, England).Rheumatology (Oxford).2012 May;51(5):887-900. Epub 2012 Jan 11.
- Objective. To investigate comprehensively the relationships between Behçet's disease (BD) clinical features and HLA-B51 or HLA-B5 (HLA-B51/B5) status using meta-analyses. Methods. Relevant publications were identified by a systematic literature search. Eligible studies had to provide frequencies fo
- PMID 22240504
- Lemierre's syndrome in a patient with habitual toothpick usage.
- Wu AY, Tseng HK, Su J, Liu CP.SourceDivision of Infectious Diseases, Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
- Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.J Microbiol Immunol Infect.2012 Apr 7. [Epub ahead of print]
- Lemierre's syndrome is characterized by septic thrombophlebitis of the internal jugular vein that is complicated by metastatic infections. The disease usually presents after oropharyngeal infection. In rare cases, odontogenic infection has been implicated as culprit. Here, we report a case of Lemier
- PMID 22487510
Japanese Journal
- TROUSSEAU A.
- Clinique Medicale de l'Hotel-Dieu de Paris, 94-96, 1865
- NAID 10007319278
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- Phlegmasia alba dolens information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Phlegmasia alba dolens: Related Topics These medical condition or symptom topics may ...
- The swelling can interfere with blood flow. This complication is called phlegmasia alba dolens. It causes the skin to turn white. Phlegmasia alba dolens may lead to tissue death (gangrene) and the need for amputation. When to ...
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