phenylpyridinium

English Journal

Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model.

Lamine A1, Létourneau M2, Doan ND2, Maucotel J3, Couvineau A4, Vaudry H3, Chatenet D5, Vaudry D3, Fournier A6.
Neuropharmacology.Neuropharmacology.2016 Sep;108:440-50. doi: 10.1016/j.neuropharm.2015.05.014. Epub 2015 May 22.
Parkinson's disease (PD) is characterized by a steady loss of dopamine neurons through apoptotic, inflammatory and oxidative stress processes. In that line of view, the pituitary adenylate cyclase-activating polypeptide (PACAP), with its ability to cross the blood-brain barrier and its anti-apoptoti
PMID 26006268

Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models.

Su C1, Yang X1, Lou J2.
Brain research.Brain Res.2016 Aug 1;1644:98-106. doi: 10.1016/j.brainres.2016.05.011. Epub 2016 May 9.
OBJECTIVE: This study aimed to explore whether the regulatory effect of miR-21 on α-synuclein expression in neurons is a potential mechanism by which geniopside (GP) protects the central nervous system from Parkinson disease (PD).METHODS: The human neuroblastoma cell line SH-SY5Y was induced to dif
PMID 27173998

Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs.

Lechner C1, Ishiguro N1, Fukuhara A1, Shimizu H1, Ohtsu N1, Takatani M1, Nishiyama K1, Washio I1, Yamamura N1, Kusuhara H2.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2016 Aug;44(8):1381-9. doi: 10.1124/dmd.115.068163. Epub 2016 Jun 6.
Multidrug and toxin extrusion transporters (MATEs) have a determining influence on the pharmacokinetic profiles of many drugs and are involved in several clinical drug-drug interactions (DDIs). Cellular uptake assays with recombinant cells expressing human MATE1 or MATE2-K are widely used to investi
PMID 27271370

Neuroprotective effect of Buddleja cordata methanolic extract in the 1-methyl-4-phenylpyridinium Parkinson's disease rat model

Therapeutic Effects of Multifunctional Tetramethylpyrazine Nitrone on Models of Parkinson's Disease in Vitro and in Vivo

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Biological and Pharmaceutical Bulletin 37(2), 274-285, 2014
… The results show that TBN exerted significant neuroprotection on 1-methyl-4-phenylpyridinium (MPP+)-induced damage in SH-SY5Y cells and primary dopaminergic neurons, as well as on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neuron loss in zebrafish (TBN and MPTP were added simultaneously into the fish embryo medium and the treatment period was 48 h). …
NAID 130003382123