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English Journal

Understanding and Avoiding Immortal-Time Bias in Gastrointestinal Observational Research.

Targownik LE1,2, Suissa S1,2.
The American journal of gastroenterology.Am J Gastroenterol.2015 Sep 1. doi: 10.1038/ajg.2015.210. [Epub ahead of print]
Pharmacoepidemiologic analyses, in which observational data is interrogated to evaluate relationships between patterns of drug use and both beneficial and adverse outcomes, are being increasingly used in the study of inflammatory bowel disease. However, the results of many of these analyses may be c
PMID 26323186

On the role of marginal confounder prevalence - implications for the high-dimensional propensity score algorithm.

Schuster T1,2, Pang M2, Platt RW1,3.
Pharmacoepidemiology and drug safety.Pharmacoepidemiol Drug Saf.2015 Sep;24(9):1004-7. doi: 10.1002/pds.3773. Epub 2015 Apr 10.
PURPOSE: The high-dimensional propensity score algorithm attempts to improve control of confounding in typical treatment effect studies in pharmacoepidemiology and is increasingly being used for the analysis of large administrative databases. Within this multi-step variable selection algorithm, the
PMID 25866189

Regularized Regression Versus the High-Dimensional Propensity Score for Confounding Adjustment in Secondary Database Analyses.

Franklin JM, Eddings W, Glynn RJ, Schneeweiss S.
American journal of epidemiology.Am J Epidemiol.2015 Aug 1. pii: kwv108. [Epub ahead of print]
Selection and measurement of confounders is critical for successful adjustment in nonrandomized studies. Although the principles behind confounder selection are now well established, variable selection for confounder adjustment remains a difficult problem in practice, particularly in secondary analy
PMID 26233956

小出大介
薬剤疫学 19(2), 133-141, 2015
日本で2012年度に「医薬品リスク管理計画指針について」が取りまとめられ，2013年度から新規に製造販売承認申請される品目に適用されてきたが，従来型の使用成績調査がほとんどである．本来の ICH E2E ガイドラインに従えば，もっと個々のリスクに対応した多彩なマネジメントができる．特に「医薬品安全性監視の方法」として医療データベースを用いた研究が可能である．かつては医療データベースが整備されておら …
NAID 130005062012

Validation of Methods to Control for Immortal Time Bias in a Pharmacoepidemiologic Analysis of Renin–Angiotensin System Inhibitors in Type 2 Diabetes

, , , , , , ,
Journal of Epidemiology 24(4), 267-273, 2014
… Background: Pharmacoepidemiologic analysis can confirm whether drug efficacy in a randomized controlled trial (RCT) translates to effectiveness in real settings. …
NAID 130003392104