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Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model.

Shao H1, Shen J2, Wang M3, Cui J1, Wang Y1, Zhu S1, Zhang W4, Yang H1, Xu Y5, Geng D6.
Biomaterials.Biomaterials.2015 Aug;60:92-9. doi: 10.1016/j.biomaterials.2015.04.048. Epub 2015 May 15.
Periprosthetic osteolysis and subsequent aseptic loosening are common in implant failure, a complication with revision surgery being the only established treatment. Wear particle-induced inflammation and extensive osteoclastogenesis play critical roles in periprosthetic osteolysis. A recent approach
PMID 25985156

Wear resistance of the biocompatible phospholipid polymer-grafted highly cross-linked polyethylene liner against larger femoral head.

Moro T1,2, Takatori Y1,2, Kyomoto M1,3,4, Ishihara K3, Kawaguchi H5, Hashimoto M6, Tanaka T2, Oshima H2, Tanaka S2.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.J Orthop Res.2015 Jul;33(7):1103-10. doi: 10.1002/jor.22868. Epub 2015 Apr 6.
The use of larger femoral heads to prevent the dislocation of artificial hip joints has recently become more common. However, concerns about the subsequent use of thinner polyethylene liners and their effects on wear rate have arisen. Previously, we prepared and evaluated the biological and mechanic
PMID 25764495

Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway.

Zhang Z1, Fang Y2, Wang Q2, Sun Y2, Xiong C2, Cao L3, Wang B1, Bao N1, Zhao J1.
Molecular medicine reports.Mol Med Rep.2015 Jul;12(1):1499-505. doi: 10.3892/mmr.2015.3529. Epub 2015 Mar 23.
Periprosthetic osteolysis is the predominant cause of artificial joint loosening. Previous studies have demonstrated that p38 mitogen-activated protein kinase (p38 MAPK) may be involved in periprosthetic osteolysis. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of th
PMID 25815691

In Vivo Imaging of Particle-Induced Inflammation and Osteolysis in the Calvariae of NFκB/Luciferase Transgenic Mice

Takahashi Kunihiko,Onodera Shin,Tohyama Harukazu,Kwon Hyuck Joon,Honma Ken-ichi,Yasuda Kazunori
Journal of Biomedicine and Biotechnology 2011, 727063, 2011
… Wear debris causes biological response which can result in periprosthetic osteolysis after total joint replacement surgery. … This system, which enabled us to evaluate particle-induced inflammation and osteolysis without sacrificing mice, constitutes a useful tool for evaluating the efficacy of prophylaxis or treatments for particle-induced osteolysis. …
NAID 120002693632