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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/01 13:50:07」(JST)

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The soma (pl. somata or somas), perikaryon (pl. perikarya), cyton, or "cell body" is the bulbous, non-process portion of a neuron or other brain cell type, containing the cell nucleus. The word "soma" comes from the Greek σῶμα, meaning "body". Although it is often used to refer to neurons, it can also refer to other cell types as well, including astrocytes,^[1] oligodendrocytes,^[2] and microglia.^[3] There are many different specialized types of neurons, and their sizes vary from as small as about 5 micrometres to over 10 millimetre for some of the smallest and largest neurons of invertebrates, respectively.

Animation in the reference.

The soma of a neuron (i.e., the main part of the neuron in which the dendrites branch off of) contains many organelles, including granules called Nissl granules, which are composed largely of rough endoplasmic reticulum and free polyribosomes.^[4] The cell nucleus is a key feature of the soma. The nucleus is the source of most of the RNA that is produced in neurons. In general, most proteins are produced from mRNAs that do not travel far from the cell nucleus. This creates a challenge for supplying new proteins to axon endings that can be a meter or more away from the soma. Axons contain microtubule-associated motor proteins that transport protein-containing vesicles between the soma and the synapses at the axon terminals. Such transport of molecules towards and away from the soma maintains critical cell functions.

The axon hillock is a specialized domain of the neuronal cell body from which the axon originates. A high amount of protein synthesis occurs in this region, as it contains a large number of Nissl granules (which are ribosomes wrapped in RER) and polyribosomes. Within the axon hillock, materials are sorted as either items that will enter the axon (like the components of the cytoskeletal architecture of the axon, mitochondria, etc.) or will remain in the soma. In addition, the axon hillock also has a specialized plasma membrane that contains large numbers of voltage-gated ion channels, since this is most often the site of action potential initiation.^[4]

The survival of some sensory neurons depends on axon terminals making contact with sources of survival factors that prevent apoptosis. The survival factors are neurotrophic factors, including molecules such as nerve growth factor (NGF). NGF interacts with receptors at axon terminals, and this produces a signal that must be transported up the length of the axon to the nucleus. A current theory of how such survival signals are sent from axon endings to the soma includes the idea that NGF receptors are endocytosed from the surface of axon tips and that such endocytotic vesicles are transported up the axon.^[5]

References

^ Bazargani, N; Attwell, D (February 2016). "Astrocyte calcium signaling: the third wave.". Nature Neuroscience. 19 (2): 182–9. PMID 26814587.
^ Baumann, N; Pham-Dinh, D (April 2001). "Biology of oligodendrocyte and myelin in the mammalian central nervous system.". Physiological reviews. 81 (2): 871–927. PMID 11274346.
^ Kozlowski, C; Weimer, RM (2012). "An automated method to quantify microglia morphology and application to monitor activation state longitudinally in vivo.". PloS one. 7 (2): e31814. PMID 22457705.
^ ^a ^b Squire, Larry; Berg, Darwin; Bloom, Floyd; du Lac, Sascha; Ghosh, Anirvan; Spitzer, Nicholas, eds. (2008). Fundamental Neuroscience (3rd ed.). Academic Press. ISBN 978-0-12-374019-9.
^ Delcroix JD, Valletta J, Wu C, et al. (2004). "Trafficking the NGF signal: implications for normal and degenerating neurons". Prog. Brain Res. 146: 3–23. PMID 14699953. doi:10.1016/s0079-6123(03)46001-9.

External links

Histology image: 3_09 at the University of Oklahoma Health Sciences Center - "Slide 3 Spinal cord"

English Journal

Thyrotropin-releasing hormone-containing axons innervate histaminergic neurons in the tuberomammillary nucleus.

Sárvári A, Farkas E, Kádár A, Zséli G, Füzesi T, Lechan RM, Fekete C.SourceDepartment of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony St, Budapest 1083, Hungary. Electronic address: fekete.csaba@koki.mta.hu.
Brain research.Brain Res.2012 Oct 11. pii: S0006-8993(12)01637-X. doi: 10.1016/j.brainres.2012.10.010. [Epub ahead of print]
Recent studies indicate that the effect of thyrotropin-releasing hormone (TRH) on the regulation of food intake may be mediated by histaminergic neurons. To elucidate the anatomical basis for a functional relationship between TRH- and histamine-synthesizing neuronal systems, double-labeling immunocy
PMID 23063458

Japanese Journal

ラフォラ病の脳病理 : 大脳皮質神経回路網内におけるポリグルコサン凝集体(Lafora小体)の局在

弘前医療福祉大学紀要 4(1), 13-24, 2013-03-29
NAID 120005286874

小児期発症の神経伝達物質疾患 : 瀬川病を中心に

脳と発達 43(5), 352-358, 2011-09-01
NAID 10029562250

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