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1. 妊娠中の体重増加／減少 weight gain and loss in pregnancy
2. 妊娠中の葉酸補充 folic acid supplementation in pregnancy
3. 無脳症 anencephaly
4. 妊娠前糖尿病：先入観に対するカウンセリング、評価、およびマネージメント pregestational diabetes preconception counseling evaluation and management
5. 神経管欠損の出生前スクリーニングおよび診断 prenatal screening and diagnosis of neural tube defects

English Journal

Effects of folic acid supplementation during different pregnancy periods and relationship with the other primary prevention measures to neural tube defects.

Gong R1,2,3, Wang ZP2, Wang M4, Gao LJ2, Zhao ZT2.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2016 Dec;29(23):3894-901. doi: 10.3109/14767058.2016.1152241. Epub 2016 Mar 29.
OBJECTIVE: To find out the prevention effects of folic acid supplements during different pregnancy periods on neural tube defects (NTDs) and the relationship of folic acid supplements with the other NTDs' primary preventive measures.METHODS: A 1:1 case-control study was conducted. Four hundred and f
PMID 27023398

Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure.

Degroote S1, Hunting DJ2, Baccarelli AA3, Takser L4.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2016 Nov 3;71:76-82. doi: 10.1016/j.pnpbp.2016.06.010. Epub 2016 Jun 21.
BACKGROUND: A growing body of evidence indicates that gut microbiota characteristics may be closely related to mental dysfunctions. However, no studies have investigated fetal brain development in relation to the maternal gut microbiota, despite the extensive use of antibiotics in obstetric practice
PMID 27346743

Duration of periconceptional folic acid supplementation in women booking for antenatal care.

Cawley S1, Mullaney L1, Kennedy R1, Farren M2, McCartney D1, Turner MJ2.
Public health nutrition.Public Health Nutr.2016 Oct 5:1-9. [Epub ahead of print]
OBJECTIVE: To provide accurate estimates of the commencement time, duration and dosage of folic acid (FA) supplementation taken by Irish women in the periconceptional period. The study also aimed to establish the factors associated with optimal FA supplementation practices.DESIGN: Cross-sectional ob
PMID 27702424

Roles of One-carbon Metabolism in Preimplantation Period : Effects on Short-term Development and Long-term Programming

IKEDA Shuntaro,KOYAMA Hiroyuki,SUGIMOTO Miki [他],KUME Shinichi
The Journal of reproduction and development 58(1), 38-43, 2012-02-01
… Recent in vivo studies have demonstrated that specific OCM dietary interventions during the periconceptional (mainly oocyte growth and preimplantation) period can cause epigenetic alterations in DNA of offspring and program the long-term consequences in their health in adulthood. …
NAID 10030406965

高橋恒男
ビタミン 83(5・6), 256-258, 2009-06-25
… (Recommendation Level B) 1) Periconceptional supplementation of 0.4mg folic acid per day is expected to reduce the incidence of NTDs. …
NAID 110007338139

平原史樹
ビタミン 83(5・6), 259-263, 2009-06-25
A number of epidemiological studies have shown that supplementation or food fortification with folic acid would reduce the incidence of neural tube defects (NTDs). In 2000, Japan Ministry of health, l …
NAID 110007338137