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Perflubron (INN/USAN, or perfluorooctyl bromide; brand name Imagent) is a contrast medium for magnetic resonance imaging, computer tomography and sonography.^[1] It was approved for this use in the United States by the Food and Drug Administration in 1993.^[2]

Experimental research

Perflubron has also been tested experimentally for use in liquid breathing in premature infants with respiratory distress.^[3]^[4]

This molecular model of Perflubron is color-coded by electron density to illustrate the positive polarisation of the large bromine atom by the inductively electron-withdrawing perfluorooctyl chain.

References

^ Mattrey, R. F. (1989). "Perfluorooctylbromide: A new contrast agent for CT, sonography, and MR imaging". AJR. American journal of roentgenology. 152 (2): 247–252. doi:10.2214/ajr.152.2.247. PMID 2643258.
^ FDA Approved Drug Products
^ Wolfson, M. R.; Kechner, N. E.; Roache, R. F.; Dechadarevian, J. P.; Friss, H. E.; Rubenstein, S. D.; Shaffer, T. H. (1998). "Perfluorochemical rescue after surfactant treatment: Effect of perflubron dose and ventilatory frequency". Journal of Applied Physiology. 84 (2): 624–640. PMID 9475875.
^ Leach, C. L.; Greenspan, J. S.; Rubenstein, S. D.; Shaffer, T. H.; Wolfson, M. R.; Jackson, J. C.; Delemos, R.; Fuhrman, B. P. (1996). "Partial Liquid Ventilation with Perflubron in Premature Infants with Severe Respiratory Distress Syndrome". New England Journal of Medicine. 335 (11): 761–767. doi:10.1056/NEJM199609123351101. PMID 8778584.

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English Journal

Safety and efficacy of perflubron-induced lung growth in neonates with congenital diaphragmatic hernia: Results of a prospective randomized trial.

Mychaliska G1, Bryner B2, Dechert R2, Kreutzman J2, Becker M2, Hirschl R2.
Journal of pediatric surgery.J Pediatr Surg.2015 Jul;50(7):1083-7. doi: 10.1016/j.jpedsurg.2015.03.004. Epub 2015 Mar 13.
BACKGROUND: Mechanical transduction has been shown to promote fetal lung growth. We examined the safety and efficacy of perflubron-induced lung growth (PILG) in neonates with congenital diaphragmatic hernia (CDH) requiring extracorporeal membrane oxygenation (ECMO).METHODS: Infants with left-sided C
PMID 25799085

Intrapulmonary instillation of perflurooctylbromide improves lung growth, alveolarization, and lung mechanics in a fetal rabbit model of diaphragmatic hernia.

Herber-Jonat S1, Vuckovic A, Mittal R, Hilgendorff A, Jani JC, Flemmer AW.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.Pediatr Crit Care Med.2014 Nov;15(9):e379-88. doi: 10.1097/PCC.0000000000000271.
OBJECTIVES: Fetal tracheal occlusion of hypoplastic rabbit lungs results in lung growth and alveolarization although the surfactant protein messenger RNA expression is decreased and the transforming growth factor-β pathway induced. The prenatal filling of healthy rabbit lungs with perfluorooctylbro
PMID 25370070

Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma.

El Mays TY, Choudhury P, Leigh R, Koumoundouros E, Van der Velden J, Shrestha G, Pieron CA, Dennis JH, Green FH, Snibson KJ.
Respiratory research.Respir Res.2014 Sep 16;15:98. doi: 10.1186/s12931-014-0098-x.
BACKGROUND: The low toxicity of perfluorocarbons (PFCs), their high affinity for respiratory gases and their compatibility with lung surfactant have made them useful candidates for treating respiratory diseases such as adult respiratory distress syndrome. We report results for treating acute allergi
PMID 25355286

Japanese Journal

Perflubron emulsion increases subcutaneous tissue oxygen tension in rats

Wound repair and regeneration 14(1), 55-60, 2006-01-01
NAID 10017318614

Partial liquid ventilation does not affect BALF TNF-, MIP-2, CINC-1 concentrations, or CD11b cell surface expression, but does increase macrophage proportion among BALF cells in the acute phase of rat LPS-induced lung injury.

Acta Medica Okayama 57(3), 2003-06
NAID 120002311778

Approach to treatment of acute respiratory failure with liquid ventilation

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 4(3), 188-192, 2001-10-01
NAID 10009652827

「パーフルブロン」

Perflubron
Clinical data
ATC code	V08CX01 (WHO) ;
Identifiers
	IUPAC name 1-Bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane;
CAS Number	423-55-2;
PubChem CID	9873;
ChemSpider	9489;
UNII	Q1D0Q7R4D9;
ChEMBL	CHEMBL1200866;
ECHA InfoCard	100.006.391
Chemical and physical data
Formula	C8BrF17
Molar mass	498.96 g/mol
3D model (JSmol)	Interactive image;
Density	1.93 g/cm3
Melting point	6 °C (43 °F)
Boiling point	142 °C (288 °F)
	SMILES FC(F)(C(F)(F)C(Br)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F;
	InChI InChI=1S/C8BrF17/c9-7(22,23)5(18,19)3(14,15)1(10,11)2(12,13)4(16,17)6(20,21)8(24,25)26; Key:WTWWXOGTJWMJHI-UHFFFAOYSA-N;

　　[★]

英: perflubron
関: ペルフルブロン

「ペルフルブロン」

　　[★]

英: perflubron
関: パーフルブロン

[1] Mattrey, R. F. (1989). "Perfluorooctylbromide: A new contrast agent for CT, sonography, and MR imaging". AJR. American journal of roentgenology. 152 (2): 247–252. doi:10.2214/ajr.152.2.247. PMID 2643258.

[2] FDA Approved Drug Products

[3] Wolfson, M. R.; Kechner, N. E.; Roache, R. F.; Dechadarevian, J. P.; Friss, H. E.; Rubenstein, S. D.; Shaffer, T. H. (1998). "Perfluorochemical rescue after surfactant treatment: Effect of perflubron dose and ventilatory frequency". Journal of Applied Physiology. 84 (2): 624–640. PMID 9475875.

[4] Leach, C. L.; Greenspan, J. S.; Rubenstein, S. D.; Shaffer, T. H.; Wolfson, M. R.; Jackson, J. C.; Delemos, R.; Fuhrman, B. P. (1996). "Partial Liquid Ventilation with Perflubron in Premature Infants with Severe Respiratory Distress Syndrome". New England Journal of Medicine. 335 (11): 761–767. doi:10.1056/NEJM199609123351101. PMID 8778584.

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perflubron