peptidoleukotriene

English Journal

Tonic stimulation of the pharyngeal mucosa causes pain and a reversible increase of inflammatory mediators.

Renner B1, Ahne G, Grosan E, Kettenmann B, Kobal G, Shephard A.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].Inflamm Res.2013 Dec;62(12):1045-51. doi: 10.1007/s00011-013-0663-7. Epub 2013 Sep 15.
OBJECTIVE AND DESIGN: To develop a model of the inflammatory component of non-infectious sore throat using tonic stimulation and quantification of inflammatory mediators in pharyngeal lavage fluid.MATERIAL OR SUBJECTS: Forty-five healthy volunteers.TREATMENT: Cold dry air.METHOD: Tonic stimulation o
PMID 24037371

Effects of steroidal and non-steroidal antiphlogistic drugs on eicosanoid synthesis in irritated skin: studies with the isolated perfused bovine udder.

Bäumer W1, Kietzmann M.
The Journal of pharmacy and pharmacology.J Pharm Pharmacol.2001 May;53(5):743-7.
Using the isolated perfused bovine udder as an in-vitro model of skin inflammation, the effects of topically administered arachidonic acid on prostaglandin and leukotriene synthesis have been shown previously. In this study, the effects of indometacin (indomethacin) and clobetasol-17-propionate (adm
PMID 11370714

Butterly DW1, Spurney RF, Ruiz P, Griffiths R, Albrightson C, Coffman TM.
Kidney international.Kidney Int.2000 Jun;57(6):2586-93.
BACKGROUND: Nephrotoxicity associated with cyclosporine A (CsA) administration is characterized by marked renal vasoconstriction, interstitial fibrosis, and arteriolar hypertrophy. While the molecular mechanisms of CsA toxicity are not well characterized, previous studies have demonstrated that alte
PMID 10844628

Effect of DS-4574, a Novel Peptidoleukotriene Antagonist with Mast Cell Stabilizing Action, on Acute Gastric Lesions and Gastric Secretion in Rats.

Tabuchi Yoshiaki,Kurebayashi Yoichi
The Japanese Journal of Pharmacology 60(4), 335-340, 1992
… DS-4574 is a peptidoleukotriene antagonist with mast cell stabilizing activity. …
NAID 130000840195

Protective Effects of a Thromboxane Synthetase Inhibitor, a Thromboxane Antagonist, a Lipoxygenase Inhibitor and a Leukotriene C_4, D_4 Antagonist on Myocardial Injury Caused by Acute Myocardial Infarction in the Canine Heart : SYMPOSIUM ON PROTECTION OF ISCHEMIC MYOCARDIUM : Basic and Clinical Research

ITO TAKAYUKI,TOKI YUKIO,HIEDA NOBUYUKI,OKUMURA KENJI,HASHIMOTO HIDEKAZU,OGAWA KOUICHI,SATAKE TATSUO
Japanese circulation journal 53(9), 1115-1121, 1989-09-20
… We studied the effects of a thromboxane A_2 synthetase inhibitor (RS-5186), a thromboxane A_2 antagonist (ONO-3708), a 5-lipoxygenase inhibitor (AA-861) and a peptidoleukotriene antagonist (ONO-1078) on infarct size, polymorphonuclear leukocyte infiltration, gross myocardial hemorrhage and arrhythmias in the canine coronary occlusion (2 hour)-reperfusion model (5 hour). …
NAID 110002605753

Protective effects of a thromboxane synthetase inhibitor, a thromboxane antagonist, a lipoxygenase inhibitor and a leukotriene C4, D4 antagonist on myocardial injury caused by acute myocardial infarction in the canine heart.

ITO TAKAYUKI,TOKI YUKIO,HIEDA NOBUYUKI,OKUMURA KENJI,HASHIMOTO HIDEKAZU,OGAWA KOUICHI,SATAKE TATSUO
JAPANESE CIRCULATION JOURNAL 53(9), 1115-1121, 1989
… antagonist (ONO-3708), a 5-lipoxygenase inhibitor (AA-861) and a peptidoleukotriene antagonist (ONO-1078) on infarct size, polymorphonuclear leukocyte infiltration, gross myocardial hemorrhage and arrhythmias in the canine coronary occlusion (2 hour)-reperfusion model (5 hour). …
NAID 130003547878