peptidoglycan glycosyltransferase

ペプチドグリカングリコシルトランスフェラーゼ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/02/15 06:48:58」(JST)

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peptidoglycan glycosyltransferase
Identifiers
EC number	2.4.1.129
CAS number	79079-04-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a peptidoglycan glycosyltransferase (EC 2.4.1.129) is an enzyme that catalyzes the chemical reaction

[GlcNAc-(1->4)-Mur₂Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n- diphosphoundecaprenol + GlcNAc-(1->4)-Mur₂Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol

⇌

[GlcNAc-(1->4)-Mur₂Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n⁺1- diphosphoundecaprenol + undecaprenyl diphosphate

The 4 substrates of this enzyme are

• [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-,
• diphosphoundecaprenol,
• GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-, and
• diphosphoundecaprenol,

whereas its 3 products are

• [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-,
• diphosphoundecaprenol, and
• undecaprenyl diphosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-mu ramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-( 1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase. Other names in common use include PG-II, bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-, pentapeptide:peptidoglycan, N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase, penicillin binding protein (3 or 1B), and peptidoglycan transglycosylase. This enzyme participates in peptidoglycan biosynthesis.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2BG1, 2UWX, and 2UWY.

References

• Taku A, Stuckey M, Fan DP (1982). "Purification of the peptidoglycan transglycosylase of Bacillus megaterium". J. Biol. Chem. 257 (9): 5018–22. PMID 6802846. 
• Goffin C, Ghuysen JM (1998). "Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs". Microbiol. Mol. Biol. Rev. 62 (4): 1079–93. PMC 98940 . PMID 9841666. 
• van Heijenoort J (2001). "Formation of the glycan chains in the synthesis of bacterial peptidoglycan". Glycobiology. 11 (3): 25R–36R. doi:10.1093/glycob/11.3.25R. PMID 11320055. 

UpToDate Contents

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• 5. A群レンサ球菌：病原性因子および発症機序 group a streptococcus virulence factors and pathogenic mechanisms

English Journal

• Cooperativity of peptidoglycan synthases active in bacterial cell elongation.

• Banzhaf M, van den Berg van Saparoea B, Terrak M, Fraipont C, Egan A, Philippe J, Zapun A, Breukink E, Nguyen-Distèche M, den Blaauwen T, Vollmer W.SourceCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Richardson Road, Newcastle upon Tyne NE2 4AX, UK Molecular Cytology, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, the Netherlands Centre d'Ingénierie des Protéines, Institut de Chimie B6a, Université de Liège, B-4000 Sart Tilman, Belgium CEA CNRS Université Joseph Fourier, Institut de Biologie Structurale, Grenoble, France Bijvoet Center for Biomolecular Research, Department of Biochemistry of Membranes, University of Utrecht, Padualaan 8, 3584 CH Utrecht, the Netherlands.
• Molecular microbiology.Mol Microbiol.2012 Jul;85(1):179-194. doi: 10.1111/j.1365-2958.2012.08103.x. Epub 2012 Jun 5.
• Growth of the bacterial cell wall peptidoglycan sacculus requires the co-ordinated activities of peptidoglycan synthases, hydrolases and cell morphogenesis proteins, but the details of these interactions are largely unknown. We now show that the Escherichia coli peptidoglycan glycosyltrasferase-tran
• PMID 22606933

• The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length.

• Helassa N, Vollmer W, Breukink E, Vernet T, Zapun A.SourceCEA, Institut de Biologie Structurale, Grenoble, France.
• The FEBS journal.FEBS J.2012 Jun;279(11):2071-81. doi: 10.1111/j.1742-4658.2012.08592.x. Epub 2012 May 8.
• The pneumococcus is an important Gram-positive pathogen, which shows increasing resistance to antibiotics, including β-lactams that target peptidoglycan assembly. Understanding cell-wall synthesis, at the molecular and cellular level, is essential for the prospect of combating drug resistance. As a
• PMID 22487093

Japanese Journal

• 大腸菌の細胞壁ペプチドグリカンを合成するモノファンクショナルグリコシルトランスフェラーゼは2種類あるか?

• 原 弘志
• 日本分子生物学会年会プログラム・講演要旨集 21, 487, 1998-12-01
• NAID 10002919298

Related Links

• Peptidoglycan glycosyltransferase substrate mimics as ...

1. Front Immunol. 2013 Mar 27;4:78. doi: 10.3389/fimmu.2013.00078. eCollection 2013. Peptidoglycan glycosyltransferase substrate mimics as templates for the design of new antibacterial drugs. Derouaux A, Sauvage E ...

• Peptidoglycan glycosyltransferase - Springer

peptidoglycan glycosyltransferase Synonyms PBP1b PG-II bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-d-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl ...

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peptidoglycan glycosyltransferase