English Journal

Betulinic acid ameliorates experimental diabetic-induced renal inflammation and fibrosis via inhibiting the activation of NF-κB signaling pathway.

Wang S1, Yang Z1, Xiong F1, Chen C1, Chao X1, Huang J1, Huang H2.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Oct 15;434:135-43. doi: 10.1016/j.mce.2016.06.019. Epub 2016 Jun 27.
Diabetic nephropathy (DN) is the leading cause of end-stage renal failure and is characterized by excessive deposition of extracellular matrix (ECM) proteins such as fibronectin (FN), in the glomerular mesangium and tubulointerstitium. Betulinic acid (BA), a pentacyclic triterpene derived from the b
PMID 27364889

Renoprotective effects of ursolic acid on ischemia/reperfusion‑induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF‑κB activities.

Peng J1, Ren X1, Lan T1, Chen Y1, Shao Z1, Yang C1.
Molecular medicine reports.Mol Med Rep.2016 Oct;14(4):3397-402. doi: 10.3892/mmr.2016.5654. Epub 2016 Aug 19.
Ursolic acid, a pentacyclic triterpene compound with low toxicity and easy availability, has a variety of biological activities, including antitumor, antioxidant, antihepatitis, anti‑inflammatory and antibacterial effects. The present study aimed to investigate the renoprotective effects of ursoli
PMID 27573738

Location of the bioactive pentacyclic triterpene ursolic acid in the membrane. A molecular dynamics study.

Fajardo-Sánchez E1, Galiano V2, Villalaín J1.
Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2016 Sep 12:1-13. [Epub ahead of print]
Ursolic acid (URS), an ursane-representative bioactive pentacyclic triterpene, is a plant secondary metabolite presenting a great number of pharmacological beneficial properties. Due to the prominent hydrophobic character of URS and its high phospholipid/water partition coefficient, some of its poss
PMID 27569018

Japanese Journal

Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity of Ursolic Acid Isolated from <i>Thymus vulgaris</i>, L.

Antiproliferative, Cell-Cycle Dysregulation Effects of Novel Asiatic Acid Derivatives on Human Non-small Cell Lung Cancer Cells

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