ペニシリンアレルギー
WordNet
- any of various antibiotics obtained from Penicillium molds (or produced synthetically) and used in the treatment of various infections and diseases
- hypersensitivity reaction to a particular allergen; symptoms can vary greatly in intensity (同)allergic_reaction
PrepTutorEJDIC
- ペニシリン(坑生物質の一種)
- アレルギー,異常過敏症
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/22 13:36:31」(JST)
[Wiki en表示]
| Penicillin drug reaction |
| Classification and external resources |
| ICD-10 |
Y40.0 |
| ICD-9 |
E930.0 |
A penicillin drug reaction is an adverse drug reaction associated with the use of penicillin.
Common adverse drug reactions (≥1% of patients) associated with use of the penicillins include diarrhea, hypersensitivity, nausea, rash, neurotoxicity, urticaria, and superinfection (including candidiasis). Infrequent adverse effects (0.1–1% of patients) include fever, vomiting, erythema, dermatitis, angioedema, seizures (especially in people with epilepsy), and pseudomembranous colitis.[1]
Pain and inflammation at the injection site is also common for parenterally administered benzathine benzylpenicillin, benzylpenicillin, and, to a lesser extent, procaine benzylpenicillin.
Although penicillin is still the most commonly reported allergy, less than 20% of all patients that believe that they have a penicillin allergy are truly allergic to penicillin;[2] nevertheless, penicillin is still the most common cause of severe allergic drug reactions.
Allergic reactions to any β-lactam antibiotic may occur in up to 1% of patients receiving that agent.[3] The allergic reaction is a Type I hypersensitivity reaction. Anaphylaxis will occur in approximately 0.01% of patients.[1] It has previously been accepted that there was up to a 10% cross-sensitivity between penicillin-derivatives, cephalosporins, and carbapenems, due to the sharing of the β-lactam ring.[4][5] However recent assessments have shown no increased risk for cross-allergy for 2nd generation or later cephalosporins.[6][7] Recent papers have shown that a major feature in determining immunological reactions is the similarity of the side chain of first generation cephalosporins to penicillins, rather than the β-lactam structure that they share.[8]
References[edit]
- ^ a b Rossi S, editor, ed. (2006). Australian Medicines Handbook. Adelaide: Australian Medicines Handbook. ISBN 0-9757919-2-3.
- ^ Salkind AR, Cuddy PG, Foxworth JW (2001). "Is this patient allergic to penicillin? An evidence-based analysis of the likelihood of penicillin allergy". JAMA 285 (19): 2498–505. doi:10.1001/jama.285.19.2498. PMID 11368703.
- ^ Solensky R (2003). "Hypersensitivity reactions to beta-lactam antibiotics". Clinical reviews in allergy & immunology 24 (3): 201–20. doi:10.1385/CRIAI:24:3:201. PMID 12721392.
- ^ Dash CH (1975). "Penicillin allergy and the cephalosporins". J. Antimicrob. Chemother. 1 (3 Suppl): 107–18. PMID 1201975.
- ^ Gruchalla RS, Pirmohamed M (2006). "Clinical practice. Antibiotic allergy". N. Engl. J. Med. 354 (6): 601–9. doi:10.1056/NEJMcp043986. PMID 16467547.
- ^ Pichichero ME (2006). "Cephalosporins can be prescribed safely for penicillin-allergic patients" (PDF). The Journal of family practice 55 (2): 106–12. PMID 16451776.
- ^ Pichichero ME (2007). "Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift". Diagn. Microbiol. Infect. Dis. 57 (3 Suppl): 13S–8S. doi:10.1016/j.diagmicrobio.2006.12.004. PMID 17349459.
- ^ Antunez C, Blanca-Lopez N, Torres MJ, et al. (2006). "Immediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins". The Journal of Allergy and Clinical Immunology 117 (2): 404–10. doi:10.1016/j.jaci.2005.10.032. PMID 16461141.
|
Drug reactions (Y40-Y59, E930-E949)
|
|
Adverse drug reaction/
drug eruption |
- antibiotics: Penicillin drug reaction
- Sulfonamide hypersensitivity syndrome
- Urticarial erythema multiforme
- Adverse effects of fluoroquinolones
- hormones: Steroid acne
- Steroid folliculitis
- chemotherapy: Chemotherapy-induced acral erythema
- Chemotherapy-induced hyperpigmentation
- Scleroderma-like reaction to taxanes
- Hydroxyurea dermopathy
- Exudative hyponychial dermatitis
- blood: Anticoagulant-induced skin necrosis
- Warfarin necrosis
- Vitamin K reaction
- Texier's disease
- anticonvulsant: Anticonvulsant hypersensitivity syndrome
- water-balance/acid-base: Allopurinol hypersensitivity syndrome
- pulmonary: Leukotriene receptor antagonist-associated Churg–Strauss syndrome
- vaccine: Eczema vaccinatum
- other specified agents: Adverse reaction to biologic agents
- Adverse reaction to cytokines
- Bromoderma
- Halogenoderma
- Iododerma
- Red man syndrome
- Methotrexate-induced papular eruption
- unspecified agent: Acute generalized exanthematous pustulosis
- Bullous drug reaction
- Drug-induced acne
- Drug-induced angioedema
- Drug-related gingival hyperplasia
- Drug-induced lichenoid reaction
- Drug-induced lupus erythematosus
- Drug-induced nail changes
- Drug-induced pigmentation
- Drug-induced pseudolymphoma
- Drug-induced urticaria
- Fixed drug reaction
- Stevens–Johnson syndrome
- Injection site reaction
- Linear IgA bullous dermatosis
- Toxic epidermal necrolysis
- HIV disease-related drug reaction
- Photosensitive drug reaction
- Serum sickness-like reaction
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UpToDate Contents
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English Journal
- Complete deficiency of the sixth complement component (C6Q0), susceptibility to Neisseria meningitidis infections and analysis of the frequencies of C6Q0 gene defects in South Africans.
- Orren A, Owen EP, Henderson HE, van der Merwe L, Leisegang F, Stassen C, Potter PC.SourceDepartment of Infection, Immunity and Biochemistry, Cardiff University, Cardiff, UK Division of Chemical Pathology, Department of Clinical Laboratory Sciences, University of Cape Town Allergy Diagnostic and Clinical Research Unit, Department of Medicine, Lung Institute, University of Cape Town Department of Human Biology, University of Cape Town Biostatistics Unit, South African Medical Research Council Department of Statistics, University of Western Cape, Cape Town, South Africa.
- Clinical and experimental immunology.Clin Exp Immunol.2012 Mar;167(3):459-471. doi: 10.1111/j.1365-2249.2011.04525.x.
- Complete complement component 6 deficiency (C6Q0) is a co-dominant genetic disease presenting as increased susceptibility to invasive Neisseria meningitidis infections. Affected individuals have two affected alleles which can be homozygous or compound heterozygous for the particular gene defects the
- PMID 22288589
Japanese Journal
- Eradication of H. pylori Infection in Patients Allergic to Penicillin Using Triple Therapy with a PPI, Metronidazole and Sitafloxacin
- , , , , , , , , , , ,
- Internal Medicine 53(6), 571-575, 2014
- … pylori in patients allergic to penicillin should be performed using regimens without penicillin derivatives. … We treated a total of 28 patients allergic to penicillin with a proton pump inhibitor (PPI), metronidazole (250 mg bid) and sitafloxacin (100 mg bid) for one to two weeks. … pylori in patients allergic to penicillin. …
- NAID 130003392718
- Characterization of Group B Streptococcus Isolated from Women in Saitama City, Japan
- , , [他], , ,
- Japanese Journal of Infectious Diseases 65(6), 516-521, 2012
- … Penicillin is recommended for intrapartum antibiotic prophylaxis; … however, other antibiotics are administered to pregnant women with penicillin allergy. …
- NAID 130002588760
- 宗 謙次,山口 仁平,岩永 哲 [他],伊東 正博,田中 藤信,小室 哲
- 耳鼻咽喉科臨床 104(3), 217-221, 2011-03-01
- … We report a case of actinomycosis involving penicillin allergy. … Due to his penicillin allergy, the man was administered clarithromycin for three months after surgery. … Almost all actinomycosis require long-term penicillin therapy. … Our case demonstrates an alternative to penicillin for those with actinomycosis but allergic to penicillin. …
- NAID 10027794218
Related Links
- Penicillin allergy — Comprehensive overview covers symptoms, causes, treatment of this allergic reaction.
- 12 Jan 2012 ... Serious allergies to penicillin are common, with about 10 percent of people reporting an allergy. However, most people who believe they are allergic can take penicillin without a problem, either because they were never truly ...
Related Pictures
★リンクテーブル★
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- 英
- penicillin allergy
- ペニシリンによるアナフィラキシー反応が生じる可能性は1万回に1-5回
- その中で死亡に至る可能性のあるものは10万回に1-2回
- 実際の頻度は0.01-0.05%
- ペニシリンアレルギーの病歴のある人の80%はアレルギーではない。