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a skin disease characterized by large thin-walled blisters (bullae) arising from normal skin or mucous membrane

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/20 16:26:05」(JST)

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Pemphigus vegetans is a localized form of pemphigus vulgaris.^[1] in which there is a localized vegetating papillomatous response. The eroded areas do not heal like usual but form papillomatous growth and vegetation.

Accounts for 1-2% of pemphigus cases and is a relatively benign variant of Pemphigus Vulgaris. Two forms are recognized:

Pemphigus vegetans of Neumann is a localized disease of pemphigus vulgaris slightly more extensive than pemphigus vegetans of Hallopeau.^[1] ^:568 This type is more common and characterized by early lesions similar to Pemphigus Vulgaris with large bullae and erosive areas. Healing is through formation of granulation tissue.
Pemphigus vegetans of Hallopeau is a disease of localized pemphigus vulgaris.^[1] ^:568 It is named for François Henri Hallopeau. This type is less aggressive and has pustules not bullae. These pustules heal by verrucios hyperkeratotic vegetations.

References

^ ^a ^b ^c Irwin M. Freedberg; et al., eds. (2003). Fitzpatrick's dermatology in general medicine. (6th ed.). New York, NY [u.a.]: McGraw-Hill. p. 558. ISBN 0-07-138076-0.

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1. 天疱瘡の病因、臨床症状、および診断pathogenesis clinical manifestations and diagnosis of pemphigus [show details]
…clinical presentations of pemphigus vegetans have been described . In pemphigus vegetans of Neumann, vegetating plaques evolve from typical pemphigus vulgaris lesions. Pemphigus vegetans of Hallopeau is a milder …
2. 尋常性天疱瘡および落葉状天疱瘡の初期マネージメントinitial management of pemphigus vulgaris and pemphigus foliaceus [show details]
…regimen for pemphigus rather than as a glucocorticoid-sparing therapy . Successful treatment of pemphigus vegetans (a rare variant of pemphigus vulgaris) with only minocycline and nicotinamide is documented…
3. 間擦性皮膚病患者へのアプローチapproach to the patient with an intertriginous skin disorder [show details]
…preparation demonstrating yeast, hyphae, and pseudohyphae confirms the diagnosis Pemphigus vegetans – Pemphigus vegetans is a variant of pemphigus that may present with vegetative plaques on intertriginous …
4. 間擦疹intertrigo [show details]
…white bands on the nails. A skin biopsy is needed to confirm the diagnosis. Pemphigus vegetans of Hallopeau – Pemphigus vegetans of Hallopeau is a variant of pemphigus that presents with vegetating plaques …
5. ヘイリー・ヘイリー病（良性家族性天疱瘡）hailey hailey disease benign familial pemphigus [show details]
…of acantholysis, and dyskeratotic cells. Pemphigus – Vegetating, flexural lesions occur in pemphigus vegetans, an uncommon variant of pemphigus vulgaris A positive direct immunofluorescence confirms the…

English Journal

Pemphigus vegetans localized to unusual sites.

Khullar G, De D1, Narang T, Saikia UN, Handa S.
Indian journal of dermatology, venereology and leprology.Indian J Dermatol Venereol Leprol.2015 Sep-Oct;81(5):509-11. doi: 10.4103/0378-6323.162317.
PMID 26261132

Pemphigus vegetans presenting as a verrucous plaque on the finger.

Vinay K1, De D2, Handa S1, Saikia UN3, Minz RW4.
Clinical and experimental dermatology.Clin Exp Dermatol.2015 Jul 24. doi: 10.1111/ced.12739. [Epub ahead of print]
PMID 26204944