ペガスパルガーゼ
- 同
- Pegaspar, Oncaspar
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/08 12:07:45」(JST)
[Wiki en表示]
Pegaspargase
Systematic (IUPAC) name |
Pegylated E. coli L-asparagine amidohydrolase
|
Clinical data |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a695031 |
Pregnancy
category |
- US: C (Risk not ruled out)
|
Legal status |
|
Identifiers |
CAS Registry Number |
130167-69-0 Y |
ATC code |
L01XX24 |
DrugBank |
DB00059 Y |
UNII |
7D96IR0PPM Y |
Chemical data |
Formula |
C1377H2208N382O442S17 |
Molecular mass |
31731.9 g/mol |
Y (what is this?) (verify) |
Pegaspargase , trade name Oncaspar, is a modified enzyme used as an antineoplastic agent. It is a form of L-asparaginase[1] which has undergone PEGylation.
It is used in the treatment of acute lymphoblastic leukemia.[2][3]
See also
PEGylation
References
- ^ "UNM Cancer Center". Retrieved 2007-08-28. [dead link]
- ^ Graham ML (2003). "Pegaspargase: a review of clinical studies". Adv. Drug Deliv. Rev. 55 (10): 1293–302. doi:10.1016/S0169-409X(03)00110-8. PMID 14499708.
- ^ Patel SS, Benfield P (Jun 1996). "New drug profile: pegaspargase (Polyethylene Glycol L-Asparaginase)". Clinical Immunotherapeutics 5 (6): 492–496.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Allergic Reactions Associated with Pegaspargase in Adults.
- Chang A1, Kim M1, Seyer M1, Patel S1.
- Leukemia & lymphoma.Leuk Lymphoma.2015 Oct 13:1-10. [Epub ahead of print]
- One of the severe toxicities of pegaspargase (PEG) is the development of allergic reactions. We retrospectively assessed 311 PEG doses administered to 139 acute lymphoblastic leukemia patients from 5/1/2008 to 7/30/2014 for allergic reactions based on the Common Terminology Criteria for Adverse Even
- PMID 26461960
- Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia.
- Vrooman LM1, Kirov II2, Dreyer ZE3, Kelly M4, Hijiya N5, Brown P6, Drachtman RA7, Messinger YH8, Ritchey AK9, Hale GA10, Maloney K11, Lu Y12, Plourde PV13, Silverman LB1.
- Pediatric blood & cancer.Pediatr Blood Cancer.2015 Sep 16. doi: 10.1002/pbc.25757. [Epub ahead of print]
- BACKGROUND: Erwinia asparaginase is antigenically distinct from E.coli-derived asparaginase and may be used after E.coli-derived asparaginase hypersensitivity. In a single-arm, multicenter study, we evaluated nadir serum asparaginase activity (NSAA) and toxicity with intravenously administered aspar
- PMID 26376459
- Radiotherapy and PGEMOX/GELOX regimen improved prognosis in elderly patients with early-stage extranodal NK/T-cell lymphoma.
- Bi XW1, Xia Y, Zhang WW, Sun P, Liu PP, Wang Y, Huang JJ, Jiang WQ, Li ZM.
- Annals of hematology.Ann Hematol.2015 Sep;94(9):1525-33. doi: 10.1007/s00277-015-2395-y. Epub 2015 May 10.
- The optimal treatment strategy for elderly patients with natural killer/T-cell lymphoma (NKTCL) remains to be established. A total of 63 elderly patients with newly diagnosed NKTCL were retrospectively reviewed. Among the patients with stage I-II disease, 58.3 % received radiotherapy (RT) ± chemot
- PMID 25957850
Related Links
- Pegaspargase / p ə ˈ ɡ æ s p ər ɡ eɪ z /, trade name Oncaspar, is a modified enzyme used as an antineoplastic agent. It is a form of L-asparaginase [1] which has undergone PEGylation. It is used in the treatment of acute ...
- Pegaspargase (Oncaspar) 原文 2006/10/5 掲載 2009/03/02 更新 このページは、pegaspargaseの簡単な説明と、本剤の用法、関連試験の結果および現在進行中の試験に関する情報へのリンク集です。
Related Pictures