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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/25 02:38:29」(JST)
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Pecilocin
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Names |
IUPAC name
1-[(2E,4E,6E,8R)-8-hydroxy-6-methyldodeca-2,4,6-trienoyl]pyrrolidin-2-one
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Identifiers |
CAS Registry Number
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19504-77-9 Y |
ATC code |
D01AA04 |
ChEMBL |
ChEMBL486174 N |
ChemSpider |
4445371 N |
EC number |
243-116-9 |
InChI
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InChI=1S/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5-6,8,10,13,15,19H,3-4,7,9,11-12H2,1-2H3/b8-5+,10-6+,14-13+/t15-/m1/s1 N
Key: ZYPGADGCNXOUJP-CXVPHVKISA-N N
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InChI=1/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5-6,8,10,13,15,19H,3-4,7,9,11-12H2,1-2H3/b8-5+,10-6+,14-13+/t15-/m1/s1
Key: ZYPGADGCNXOUJP-CXVPHVKIBE
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Jmol-3D images |
Image |
KEGG |
D01458 Y |
PubChem |
5282176 |
SMILES
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CCCC[C@H](/C=C(\C)/C=C/C=C/C(=O)N1CCCC1=O)O
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UNII |
TSA7W27MF8 N |
Properties |
Chemical formula
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C17H25NO3 |
Molar mass |
291.3853 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is: Y/N?) |
Infobox references |
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Pecilocin is an antibiotic.
English Journal
- Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
- Mizushina Y1, Suzuki-Fukudome H2, Takeuchi T2, Takemoto K2, Kuriyama I3, Yoshida H3, Kamisuki S2, Sugawara F2.
- Bioorganic & medicinal chemistry.Bioorg Med Chem.2014 Feb 1;22(3):1070-6. doi: 10.1016/j.bmc.2013.12.038. Epub 2013 Dec 25.
- Variotin (1) and three novel compounds, formosusin A (2), B (3), and C (4), were isolated from the cultures of the fungus Paecilomyces formosus, and their structures were determined by spectroscopic analyses. Compound 2 is (6Z,8E,10E)-variotin, a new cis-olefin analog of compound 1. Compound 2 selec
- PMID 24411199
- New variotin analogues from Aspergillus viridi-nutans.
- Omolo JO1, Anke H, Chhabra S, Sterner O.
- Journal of natural products.J Nat Prod.2000 Jul;63(7):975-7.
- Besides the antifungal agents variotin (1), wasabidienone B(0) (4), and phomaligin A (5), two new but inactive metabolites, viriditin (2) and O-methylviriditin (3), were isolated from extracts of the culture filtrate of liquid cultures of a strain of Aspergillus viridi-nutans. In addition, wasabidie
- PMID 10924177
- [Antimycotic therapy. 3: Polyene antimycotic antibiotics, antimycotic antibiotics without polyene structure].
- Qadripur SA.
- Fortschritte der Medizin.Fortschr Med.1983 Mar 24;101(11):465-9.
- PMID 6852709
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