WordNet

extreme hostility; "the virulence of the malicious old man" (同)virulency
extreme harmfulness (as the capacity of a microorganism to cause disease); "the virulence of the plague" (同)virulency
the origination and development of a disease
infectious; having the ability to cause disease

PrepTutorEJDIC

有毒,毒性 / 憎悪,敵意
病原性(微生物が病気を起こす能力)
有毒な,毒性の / 憎悪に満ちた,敵意に満ちた
発病させる,病原性の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/20 18:08:04」(JST)

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The pathogenesis of a disease is the biological mechanism (or mechanisms) that lead to the diseased state. The term can also describe the origin and development of the disease, and whether it is acute, chronic, or recurrent. The word comes from the Greek pathos ("disease") and genesis ("creation").

Types of pathogenesis include microbial infection, inflammation, malignancy and tissue breakdown. For example bacterial pathogenesis is the mechanism by which bacteria cause infectious illness.

Most diseases are caused by multiple processes. For example, certain cancers arise from dysfunction of the immune system (skin tumors and lymphoma after a renal transplant, which requires immunosuppression).^[1]^[2]

The pathogenetic mechanisms of a disease (or condition) are set in motion by underlying etiological causes, which if controlled would allow the disease to be prevented.^[3] Often, a potential etiology is identified by epidemiological observations before a pathological link can be drawn between the cause and the disease. The pathological perspective can be directly integrated into an epidemiological approach in the interdisciplinary field of molecular pathological epidemiology (MPE).^[4] MPE can help to assess pathogenesis and causality by means of linking a potential etiologic factor to molecular pathologic signatures of a disease.^[5] Thus, the MPE paradigm can advance the area of causal inference.

References

^ Fox A (2010). General aspects of bacterial pathogenesis. University of South Carolina School of Medicine: Microbiology and Immunology On-line Textbook.
^ Miquel Porta, Greenland S, Hernán M, dos Santos Silva I, Last JM, ed. (2014). ['http://global.oup.com/academic/product/a-dictionary-of-epidemiology-9780199976737?cc=us&lang=en A dictionary of epidemiology.] (6th ed.). Oxford: Oxford University Press. ISBN 9780199976737.
^ Last, JM, ed. (2000). A Dictionary of Epidemiology (4th ed.). Oxford: Oxford University Press. p. 132. ISBN 978-0-19-977434-0.
^ Ogino S, Stampfer M (2010). "Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology". J. Natl. Cancer Inst. 102 (6): 365–7. doi:10.1093/jnci/djq031. PMC 2841039. PMID 20208016.
^ Ogino S, Chan AT, Fuchs CS, Giovannucci E (2011). "Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field". Gut 60 (3): 397–411. doi:10.1136/gut.2010.217182. PMC 3040598. PMID 21036793.

UpToDate Contents

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1. 原発性骨髄線維症における病態 pathogenetic mechanisms in primary myelofibrosis
2. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
3. The epidemiology and pathogenesis of pulmonary arterial hypertension (Group 1)
4. 自己免疫の概要 overview of autoimmunity
5. 黒色腫発症の危険因子 risk factors for the development of melanoma

English Journal

Evaluation of the first fully automated immunoassay method for the measurement of stimulating TSH receptor autoantibodies in Graves' disease.

Tozzoli R, D'Aurizio F, Villalta D, Giovanella L.
Clinical chemistry and laboratory medicine.Clin Chem Lab Med.2017 Jan 1;55(1):58-64. doi: 10.1515/cclm-2016-0197.
BACKGROUND: Thyroid stimulating hormone (TSH) receptor autoantibodies (TRAb) are pathogenetic and diagnostic hallmarks of Graves' disease (GD). Three varieties of TRAb have been described: stimulating (S-TRAb), blocking (B-TRAb), and apoptotic (A-TRAb) autoantibodies. Very recently, the first immuno
PMID 27331310

Expanding the molecular signature of ossifying fibromyxoid tumors with two novel gene fusions: CREBBP-BCORL1 and KDM2A-WWTR1.

Kao YC1,2, Sung YS2, Zhang L2, Chen CL2, Huang SC2,3, Antonescu CR2.
Genes, chromosomes & cancer.Genes Chromosomes Cancer.2017 Jan;56(1):42-50. doi: 10.1002/gcc.22400. Epub 2016 Aug 26.
Ossifying fibromyxoid tumor (OFMT) is an uncommon mesenchymal neoplasm of uncertain differentiation and intermediate malignant potential. Recurrent gene fusions involving either PHF1 or BCOR have been found in 85% of OFMT, including typical and malignant examples. As a subset of OFMT still lack know
PMID 27537276

Current Trends and Alternative Scenarios in EBV Research.

Minarovits J1, Niller HH2.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2017;1532:1-32.
Epstein-Barr virus (EBV) infection is associated with several distinct hematological and epithelial malignancies, e.g., Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, gastric carcinoma, and others. The association with several malignant tumors of local and worldwide distribution makes
PMID 27873264

Japanese Journal

Half a Century Tales of Familial Hypercholesterolemia (FH) in Japan

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 24(3), 189-207, 2017
NAID 130005397939

Molecular characterization and phylogeny of Linguatula serrata (Pentastomida: Linguatulidae) based on the nuclear 18S rDNA and mitochondrial cytochrome c oxidase I gene

Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 79(2), 398-402, 2017
NAID 130005397098

Degenerative myelopathy in the Collie breed: a retrospective immunohistochemical analysis of superoxide dismutase 1 in an affected Rough Collie, and a molecular epidemiological survey of the SOD1: c.118G>A mutation in Japan