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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/08 18:07:45」(JST)

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Pargyline (Eutonyl) is an irreversible monoamine oxidase B (MAO-B) inhibitor.^[1] It has antihypertensive effects.^[2]

Pharmacology[edit]

It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis.^[3]

References[edit]

^ Murphy DL, Karoum F, Pickar D, et al. (1998). "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)". J. Neural Transm. Suppl. 52: 39–48. PMID 9564606.
^ Fuentes JA, Ordaz A, Neff NH (July 1979). "Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats". Eur. J. Pharmacol. 57 (1): 21–7. doi:10.1016/0014-2999(79)90099-2. PMID 477738.
^ Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006

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English Journal

The metabolism of histamine in rat hypothalamus and cortex after reserpine treatment.

Maldonado M1, Maeyama K2.
Neurochemistry international.Neurochem Int.2015 Jun-Jul;85-86:31-9. doi: 10.1016/j.neuint.2015.04.005. Epub 2015 Apr 29.
The effect of reserpine on histamine (HA) and tele-methylhistamine (N(τ)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines. IP injection of reserpine (5 mg/kg) confirmed the effectiveness of reserpine treatment on noradrenaline and dopamine levels. Our in-vitro e
PMID 25936509

Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice.

Barros-Miñones L1, Goñi-Allo B1, Suquia V1, Beitia G1, Aguirre N1, Puerta E2.
Neuropharmacology.Neuropharmacology.2015 Jun;93:124-33. doi: 10.1016/j.neuropharm.2015.01.025. Epub 2015 Feb 7.
Methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that MDMA-induced neurotoxicity is mediated by oxidative stress probably due to the inhibition of mitochondrial complex I activity. In this study we i
PMID 25666033

D1 Antagonists and D2 Agonists Have Opposite Effects on the Metabolism of Dopamine in the Rat Striatum.

Avila-Luna A1, Prieto-Leyva J, Gálvez-Rosas A, Alfaro-Rodriguez A, Gonzalez-Pina R, Bueno-Nava A.
Neurochemical research.Neurochem Res.2015 May 17. [Epub ahead of print]
The striatum is known to possess high levels of D1-like and D2-like receptors (D1Rs and D2Rs, respectively). We have previously shown that selective inhibition of D1Rs increases the dopaminergic metabolic response and proposed that this effect is associated with the concomitant activation of postsyn
PMID 25981954

Japanese Journal

Nicotine-Induced Noradrenaline Release From the Isolated Rat Stomach by Activation of L- and N-type Calcium Channels

, , [他],
The Japanese journal of pharmacology 83(2), 102-106, 2000-06-01
… examined the effect of nicotine on the release of endogenous noradrenaline(NA)from the isolated, vascularly perfused rat stomach.The stomach was perfused via the coeliac artery with Krebs−Ringer solution containing 10 μM pargyline at a constant flow rate of 4 ml per minute.Nicotine was once applied in the perfusion medium for 2 min.Nicotine(10-6−10-4M)evoked NA release in a concentration−dependent manner.The nicotine(3×10-5M)−evoked NA release was abolished by hexamethonium …
NAID 10007366853

Involvement of Multiple Copper/Topa Quinone-Contanining and Flavin-Containing Amine Oxidases and NAD(P)^+ Aldehyde Dehydrogenases in Amine Degradation by Filamentous Fungi

Frebort Ivo,Matsushita Kazunobu,Adachi Osao
Journal of fermentation and bioengineering 84(3), 200-212, 1997-09-25
… However, the enzymatic activities of extracts that contained non-coopper amine oxidases was substantially decreased by pargyline, an inhibitor specific to flavin-containing amine oxidases. …
NAID 110002682599

第18回カテコールアミンと循環器系研究会心臓交感神経刺激時の心筋間質ノルエピネフリン動態に影響を及ぼす交感神経終末機能の解析

北川裕利,秋山剛,山崎登自
心臓 29(Supplement2), 43-48, 1997
NAID 130004136013

「パージリン」

Pargyline
Systematic (IUPAC) name
	N-Benzyl-N-methylprop-2-yn-1-amine
Clinical data
MedlinePlus	a682088
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	555-57-7
ATC code	C02KC01 C02LL01
PubChem	CID 4688
DrugBank	DB01626
ChemSpider	4526
UNII	9MV14S8G3E
ChEMBL	CHEMBL673
Chemical data
Formula	C11H13N
Mol. mass	159.23 g/mol
	SMILES C#CCN(C)Cc1ccccc1;
	InChI InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3 ; Key:DPWPWRLQFGFJFI-UHFFFAOYSA-N ;
(what is this?) (verify);

　　[★]

英: pargyline
関: パルギリン

[pmid9564606-1] Murphy DL, Karoum F, Pickar D, et al. (1998). "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)". J. Neural Transm. Suppl. 52: 39–48. PMID 9564606.

[pmid477738-2] Fuentes JA, Ordaz A, Neff NH (July 1979). "Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats". Eur. J. Pharmacol. 57 (1): 21–7. doi:10.1016/0014-2999(79)90099-2. PMID 477738.

[3] Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006

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pargyline