パラオキソナーゼ
- 関
- aryldialkylphosphatase、organophosphorus hydrolase、PON
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/17 16:56:34」(JST)
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paraoxonase 1 |
Identifiers |
Symbol |
PON1 |
Alt. symbols |
PON |
Entrez |
5444 |
HUGO |
9204 |
OMIM |
168820 |
RefSeq |
NM_000446 |
UniProt |
P27169 |
Other data |
EC number |
3.1.8.1 |
Locus |
Chr. 7 q21.3 |
paraoxonase 2 |
Identifiers |
Symbol |
PON2 |
Entrez |
5445 |
HUGO |
9205 |
OMIM |
602447 |
RefSeq |
NM_000305 |
UniProt |
Q15165 |
Other data |
EC number |
3.1.8.1 |
Locus |
Chr. 7 q21.3 |
paraoxonase 3 |
Identifiers |
Symbol |
PON3 |
Entrez |
5446 |
HUGO |
9206 |
OMIM |
602720 |
RefSeq |
NM_000940 |
UniProt |
Q15166 |
Other data |
EC number |
3.1.8.1 |
Locus |
Chr. 7 q21.3 |
Paraoxonases are a group of enzymes involved in the hydrolysis of organophosphates.[1]
Contents
- 1 History
- 2 Types
- 3 Clinical Significance
- 4 External links
- 5 References
|
History [edit]
PON was identified as an enzyme having organophosphates as its substrates. Reports of the geographic differences in population frequencies of paraoxonase activity and genetic analysis led to uncovering the genetic polymorphism.
Types [edit]
There are 3 known genotypic forms of paraoxonases. They are coded for by the PON set of genes – PON1, PON2 and PON3 – located on the long arm of chromosome 7.[2][3] The differences between them lie in their location and activity.
- PON1 is synthesized in the liver and transported along with HDL in the plasma. It functions as an antioxidant; it prevents the oxidation of LDL. Its serum concentration is influenced by inflammatory changes and the levels of serum oxidised-LDL.
- PON2 is a ubiquitously expressed intracellular protein that can protect cells against oxidative damage.[4]
- PON3 is similar to PON1 in activity but differs from it in substrate specificity. Additionally, it is not regulated by inflammation and levels of oxidised lipids.[5]
Clinical Significance [edit]
PON1 and PON3 are implicated in lowering the risk of developing coronary artery disease and atherosclerosis. PON1 and PON3 prevent the formation of atherogenic oxidised-LDL, the form of LDL present in foam cells of an atheromatous plaque.
External links [edit]
References [edit]
- ^ La Du BN (1992). "Human serum paraoxonase/arylesterase". In Kalow W, editor. Pharmacogenetics of drug metabolism. New York: Pergamon Press. pp. pages 51–91. ISBN 0-08-041175-4.
- ^ Bergmeier C, Siekmeier R, Gross W (December 2004). "Distribution spectrum of paraoxonase activity in HDL fractions". Clin. Chem. 50 (12): 2309–15. doi:10.1373/clinchem.2004.034439. PMID 15459089.
- ^ Li HL, Liu DP, Liang CC (2003). "Paraoxonase gene polymorphisms, oxidative stress, and diseases". JOURNAL OF MOLECULAR MEDICINE 81 (12): 766–779. PMID 14551701.
- ^ Ng CJ, Wadleigh DJ, Gangopadhyay A et al. (November 2001). "Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein". J. Biol. Chem. 276 (48): 44444–9. doi:10.1074/jbc.M105660200. PMID 11579088.
- ^ Reddy ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, Gangopadhyay A, Shih DM, Lusis AJ, Navab M, Fogelman AM (April 2001). "Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids". Arterioscler. Thromb. Vasc. Biol. 21 (4): 542–7. doi:10.1161/01.ATV.21.4.542. PMID 11304470.
UpToDate Contents
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English Journal
- Triton X-114 cloud point extraction to subfractionate blood plasma proteins for two-dimensional gel electrophoresis.
- Jessen F1, Wulff T2.
- Analytical biochemistry.Anal Biochem.2015 Sep 15;485:11-7. doi: 10.1016/j.ab.2015.05.025. Epub 2015 Jun 14.
- A simple and reproducible procedure for enrichment of a plasma protein subfraction suitable for two-dimensional polyacrylamide gel electrophoresis (2DE) was developed, using a Triton X-114-based cloud point extraction (CPE). Appropriate conditions for such a CPE procedure were found by SDS-PAGE to b
- PMID 26080275
- Q192R and L55M Polymorphisms of Paraoxonase 1 Gene in Chronic Myelogenous Leukemia and Chronic Lymphocytic Leukemia.
- Tomatir AG1, Pehlivan S2, Sahin HH3, Balci SO4, Budeyri S3, Pehlivan M3.
- Anticancer research.Anticancer Res.2015 Sep;35(9):4807-12.
- AIM: The aim of the present study was to investigate the association between Paraoxonase 1 (PON1) gene polymorphisms Q192R, and L55M in patients with Chronic Myelogenous Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL) patients.MATERIALS AND METHODS: We analyzed samples from 60 patients with CM
- PMID 26254371
- 5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1.
- Eryanni-Levin S1, Khatib S2, Levy-Rosenzvig R1, Tamir S1, Szuchman-Sapir A3.
- Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1851(9):1118-22. doi: 10.1016/j.bbalip.2015.04.008. Epub 2015 May 6.
- Paraoxonase 1 (PON1) is an antiatherogenic high density lipoprotein-associated lactonase. Recent findings revealed that PON1 knockout mice have low blood pressure, which is negatively correlated with the level of 5,6-epoxyeicosatrienoic acid (5,6-EET), a cytochrome P450 -derived arachidonic acid met
- PMID 25958017
Japanese Journal
- Effect of cigarette smoking on paraoxonase 1 activity according to PON1 L55M and PON1 Q192R gene polymorphisms
- MOUHAMED Dhouha Haj,EZZAHER Asma,MECHRI Anwar,NEFFATI Fadoua,OMEZZINE Asma,BOUSLAMA Ali,GAHA Lotfi,DOUKI Wahiba,NAJJAR Mohamed Fadhel
- Environmental health and preventive medicine 17(4), 316-321, 2012-07-01
- NAID 10030945880
- Paraoxonase-1 and clopiclogrel resistance
- Paraoxonase 1 Correlates with Butyrylcholinesterase and Gamma Glutamyl Transferase in Workers Chronically Exposed to Pesticides
- ARAOUD Manel,NEFFETI Fadoua,DOUKI Wahiba,NAJJAR Mohamed Fadhel,KENANI Abderraouf
- Journal of occupational health 52(6), 383-388, 2010-11-01
- NAID 10026964722
Related Links
- Paraoxonase1(PON1)についてちょっと調べた・・・パラオキソナーゼ1(PON1)は哺乳動物の高比重リポ蛋白質(HDL)に分布する酵素で,リポ... ... Paraoxonase 1 (PON1)についてちょっと調べた・・・パラオキソナーゼ1(PON1)は哺乳動物の高比重 ...
- キーワード 抗酸化酵素、HDL、粥状動脈硬化症 歴史とあらまし Paraoxonase 1 (PON1)は有機リン酸塩を加水分解する酵素として発見され,殺虫剤パラチオンの代謝物であるパラオキソンを加水分解することから,パラオキソナーゼと命名 ...
Related Pictures
★リンクテーブル★
[★]
有機リン加水分解酵素、有機リンヒドロラーゼ
- 関
- aryldialkylphosphatase、paraoxonase
[★]
アリールジアルキルホスファターゼ
- 関
- organophosphorus hydrolase、paraoxonase
[★]
- 英
- [[]]
- 同
- paraoxonase
- 関
- [[]]
- 同
- paraoxonase
[★]
パラオキソナーゼ
- 関
- paraoxonase