English Journal

Identification of a novel nonsense mutation in the rod domain of GFAP that is associated with Alexander disease.

Nam TS1, Kim JH2, Chang CH3, Yoon W4, Jung YS5, Kang SY6, Shin BA7, Perng MD3, Choi SY8, Kim MK1.
European journal of human genetics : EJHG.Eur J Hum Genet.2015 Jan;23(1):72-8. doi: 10.1038/ejhg.2014.68. Epub 2014 Apr 23.
Alexander disease (AxD) is an astrogliopathy that primarily affects the white matter of the central nervous system (CNS). AxD is caused by mutations in a gene encoding GFAP (glial fibrillary acidic protein). The GFAP mutations in AxD have been reported to act in a gain-of-function manner partly beca
PMID 24755947

Immunostaining and time-lapse analysis of vinblastine-induced paracrystal formation in human A549 cells.

Nakamura Y1, Ishigaki Y1.
Oncology letters.Oncol Lett.2014 Dec;8(6):2387-2392. Epub 2014 Sep 18.
Vinblastine is a vinca alkaloid that binds to tubulin and inhibits microtubule formation in cells. Vinblastine treatment results in the formation of paracrystalline aggregates in the cells, which are formed from tightly packed tubulin molecules. Mitotic spindle assemblies in treated cells are disrup
PMID 25364400

Correlation of actin crosslinker and capper expression levels with stereocilia growth phases.

Avenarius MR1, Saylor KW, Lundeberg MR, Wilmarth PA, Shin JB, Spinelli KJ, Pagana JM, Andrade L, Kachar B, Choi D, David LL, Barr-Gillespie PG.
Molecular & cellular proteomics : MCP.Mol Cell Proteomics.2014 Feb;13(2):606-20. doi: 10.1074/mcp.M113.033704. Epub 2013 Dec 7.
During development of the chick cochlea, actin crosslinkers and barbed-end cappers presumably influence growth and remodeling of the actin paracrystal of hair cell stereocilia. We used mass spectrometry to identify and quantify major actin-associated proteins of the cochlear sensory epithelium from
PMID 24319057