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a benign epithelial tumor forming a rounded mass (同)villoma, papillary_tumor, papillary tumour

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/19 01:27:15」(JST)

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A papilloma (plural papillomas or papillomata) (papillo- + -oma) is a benign epithelial tumor^[1] growing exophytically (outwardly projecting) in nipple-like and often finger-like fronds. In this context papilla refers to the projection created by the tumor, not a tumor on an already existing papilla (such as the nipple).

When used without context, it frequently refers to infections (squamous cell papilloma) caused by human papillomavirus (HPV), such as warts. Human papillomavirus infection is a major cause of cervical cancer, although most HPV infections do not cause cancer. There are, however, a number of other conditions that cause papilloma, as well as many cases in which there is no known cause.

Description

A benign papillomatous tumor derived from epithelium. Cauliflower-like projections that arise from the mucosal surface. It may appear white or normal colored. It may be pedunculated or sessile. The average size is between 1–5 cm. No strong sex preference. The most common site was the palate-uvula area followed by tongue and lips. The durations ranged from weeks to 10 years.

Etiology

Immunoperoxidase stains have identified antigens of the human papillomavirus (HPV) types 6 and 11 in approximately 50% of cases of squamous cell papilloma.

Prognosis

There is no evidence that papillomas are premalignant.

Differential diagnosis

Intraoral verruca vulgaris,
Condyloma acuminatum, and
Focal epithelial hyperplasia.

Note: differentiation is done accurately by microscopic examination only.

Treatment

Conservative surgical excision, recurrence is rare.

References

^ "papilloma" at Dorland's Medical Dictionary

External links

Choroid Plexus Papilloma - Palmer, Cheryl Ann and Daniel Keith Harrison; EMedicine; Jun 5, 2008
Types of papilloma
Squamous cell papilloma
"Papilloma bladder". Medcyclopaedia. GE. Archived from the original on 2012-02-05.

UpToDate Contents

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1. 良性乳房疾患の概要 overview of benign breast disease
2. 頭頸部腫瘍の病理 pathology of head and neck neoplasms
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4. 食道の良性病変 benign lesions of the esophagus
5. 膀胱腫瘍の病理 pathology of bladder neoplasms

English Journal

Noninvasive assessment of mitochondrial organization in three-dimensional tissues reveals changes associated with cancer development.

Xylas J1, Varone A, Quinn KP, Pouli D, McLaughlin-Drubin ME, Thieu HT, Garcia-Moliner ML, House M, Hunter M, Munger K, Georgakoudi I.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jan 15;136(2):322-32. doi: 10.1002/ijc.28992. Epub 2014 Jun 5.
Mitochondrial organization is often altered to accommodate cellular bioenergetic and biosynthetic demands. Changes in metabolism are a hallmark of a number of diseases, including cancer; however, the interdependence between mitochondrial metabolic function and organization is not well understood. He
PMID 24862444

Human Papilloma Virus (HPV) Modulation of the HNSCC Epigenome.

Stephen JK1, Worsham MJ.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2015;1238:369-79. doi: 10.1007/978-1-4939-1804-1_20.
Currently, the human papilloma virus (HPV), in addition to tobacco and alcohol, is considered another independent risk factor for oropharyngeal squamous head and neck cancer (OPSCC), where the prevalence of HPV-16 increases to 50-90 % for the oropharynx. Also, incidence and mortality in head and nec
PMID 25421671

Cancer-associated infectious agents and epigenetic regulation.

Vedham V1, Verma M.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2015;1238:333-54. doi: 10.1007/978-1-4939-1804-1_18.
Infectious agents are one of the factors which contribute to cancer development. Few examples include human papilloma virus in cervical cancer, hepatitis virus in hepatocellular carcinoma, herpes virus in Kaposi's sarcoma, Epstein-Barr virus in nasopharyngeal carcinoma, human T-cell lymphotropic vir
PMID 25421669