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Palmitoyl-CoA is an acyl-CoA thioester used in the biosynthesis of sphingosine:^[1]^[2]

Palmitoyl-CoA is part of the carnitine shuttle system, which transports other fatty acyl-CoA molecules into the mitochondria for β-oxidation.

Additional images

Synthesis
Palmitic acid
Coenzyme A

References

^ Brady, R.N.; DiMari, S.J.; Snell, E.E. (1969). "Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri". J. Biol. Chem. 244: 491–496. PMID 4388074.
^ Stoffel, W.; Le Kim, D.; Sticht, G. (1968). "Biosynthesis of dihydrosphingosine in vitro". Hoppe-Seyler's Z. Physiol. Chem. 349: 664–670. doi:10.1515/bchm2.1968.349.1.664. PMID 4386961.

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UpToDate Contents

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1. 脂質およびプリン代謝障害による代謝性ミオパチー metabolic myopathies caused by disorders of lipid and purine metabolism
2. 代謝性ミオパチーへのアプローチ approach to the metabolic myopathies
3. 遺伝性感覚自律神経ニューロパチー hereditary sensory and autonomic neuropathies
4. ウイルス性筋炎 viral myositis
5. 横紋筋融解症の原因 causes of rhabdomyolysis

English Journal

Role of mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes.

Han C, Wan H, Ma S, Liu D, He F, Wang J, Pan Z, Liu H, Li L, He H, Xu H, Wei S, Xu F.SourceInstitute of Animal Breeding & Genetic, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address: chunchunhai_510@163.com.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2014 Jan 25;382(1):282-91. doi: 10.1016/j.mce.2013.10.012. Epub 2013 Oct 19.
Our result showed in the fatty liver formation induced-by overfeeding goose, it was accompanied by an activation of mammalian target of rapamycin (mTOR) pathway and cell proliferation. Recent studies have suggested a crucial role for mammalian sirtuin 1 (SIRT1) in regulating lipid metabolism and cel
PMID 24145124

Activation of PPAR α and PPAR β/δ regulates Sertoli cell metabolism.

Regueira M, Riera MF, Galardo MN, Pellizzari EH, Cigorraga SB, Meroni SB.SourceCentro de Investigaciones Endocrinólogicas "Dr Cesar Bergadá" (CEDIE-CONICET), Hospital de Niños "R. Gutiérrez", Gallo 1330, C1425EDF Buenos Aires, Argentina.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2014 Jan 25;382(1):271-81. doi: 10.1016/j.mce.2013.10.006. Epub 2013 Oct 12.
The purpose of this study was to evaluate the existence of a possible simultaneous regulation of fatty acid (FA) metabolism and lactate production by PPAR α and PPAR β/δ activation in Sertoli cells (SC). SC cultures obtained from 20-day-old rats were incubated with WY14643 or GW0742-pharmacologic
PMID 24128860

l-carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders.

Ribas GS, Vargas CR, Wajner M.SourceFederal University of Rio Grande do Sul, Brazil; Serviço de Genética Médica, HCPA, Ramiro Barcelos 2350, Porto Alegre, RS 90035-903, Brazil.
Gene.Gene.2014 Jan 10;533(2):469-76. doi: 10.1016/j.gene.2013.10.017. Epub 2013 Oct 19.
In recent years increasing evidence has emerged suggesting that oxidative stress is involved in the pathophysiology of a number of inherited metabolic disorders. However the clinical use of classical antioxidants in these diseases has been poorly evaluated and so far no benefit has been demonstrated
PMID 24148561

Japanese Journal

Mechanisms of exercise- and training-induced fatty acid oxidation in skeletal muscle

Miura Shinji,Tadaishi Miki,Kamei Yasutomi [他]
The journal of physical fitness and sports medicine : JPFSM : official journal of the Japanese Society of Physical Fitness and Sports Medicine 3(1), 43-53, 2014-03
NAID 40020028870

横紋筋融解の既往を有するカルニチンパルミトイルトランスフェラーゼ欠損症患者の麻酔経験

中村彩加,杉田道子,中原依里子 [他]
麻酔 62(3), 354-357, 2013-03
NAID 40019602141

Alleviation of Weight-Gain in Mice by an Ethanolic Extract from Rubus coreanus under Conditions of a High-Fat Diet and Exercise

CHUNG Changsik,YOU Yanghee,YOON Ho-Geun,KIM Kyungmi,LEE Yoo-Hyun,LEE Jeongmin,CHUNG Jin Woong,CHUNG Hyunjung,YANG Soojin,JUN Woojin
Bioscience, Biotechnology, and Biochemistry 77(10), 2148-2150, 2013
… The mice also displayed enhanced muscular carnitine palmitoyltransferase 1 (CPT1) expression and increased superoxide dismutase and glutathione levels. …
NAID 130003381896

Related Pictures

★リンクテーブル★

リンク元	「パルミチン酸転移酵素」「パルミトイルトランスフェラーゼ」
拡張検索	「carnitine palmitoyltransferase」「serine palmitoyltransferase」

「パルミチン酸転移酵素」

Palmitoyl-CoA
Identifiers
CAS Number	1763-10-6
ChemSpider	559149
Jmol 3D model	Interactive image
KEGG	C00154
MeSH	Palmitoyl+Coenzyme+A
PubChem	644109
	InChI InChI=1S/C37H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h24-26,30-32,36,47-48H,4-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/t26-,30-,31-,32+,36-/m1/s1 Key: MNBKLUUYKPBKDU-BBECNAHFSA-N ; InChI=1/C37H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h24-26,30-32,36,47-48H,4-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/t26-,30-,31-,32+,36-/m1/s1 Key: MNBKLUUYKPBKDU-BBECNAHFBL ;
	SMILES CCCCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)OP(=O)(O)O)O ;
Properties
Chemical formula	C37H66N7O17P3S
Molar mass	1004.94 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

英: palmitoyltransferase
関: パルミトイルトランスフェラーゼ

「パルミトイルトランスフェラーゼ」

　　[★]

英: palmitoyltransferase
関: パルミチン酸転移酵素

「carnitine palmitoyltransferase」

　　[★]

カルニチンパルミトイルトランスフェラーゼ

関: carnitine O-palmitoyltransferase

「serine palmitoyltransferase」

　　[★]

セリンパルミトイルトランスフェラーゼ

関: serine C-palmitoyltransferase

[1] Brady, R.N.; DiMari, S.J.; Snell, E.E. (1969). "Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri". J. Biol. Chem. 244: 491–496. PMID 4388074.

[2] Stoffel, W.; Le Kim, D.; Sticht, G. (1968). "Biosynthesis of dihydrosphingosine in vitro". Hoppe-Seyler's Z. Physiol. Chem. 349: 664–670. doi:10.1515/bchm2.1968.349.1.664. PMID 4386961.

匿名

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案内

案内

palmitoyltransferase