パクリタキセル・リグルメクス、パクリタキセル・・リグルメクス
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English Journal
- PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation: A Randomized Phase II Study: BrUOG 244.
- Elinzano H1, Glantz M, Mrugala M, Kesari S, Piccioni DE, Kim L, Pan E, Yunus S, Coyle T, Timothy K, Evans D, Mantripragada K, Boxerman J, DiPetrillo T, Donahue JE, Hebda N, Mitchell KM, Rosati KL, Safran H.
- American journal of clinical oncology.Am J Clin Oncol.2015 Dec 9. [Epub ahead of print]
- PURPOSE: Efficacy signals but substantial myelosuppression were demonstrated in a single arm phase II study of paclitaxel poliglumex (PPX) in combination with temozolomide (TMZ) and radiation therapy (RT) for first-line treatment of glioblastoma. The objective of this randomized phase II trial was t
- PMID 26658237
- Growth Attenuation of Cutaneous Angiosarcoma With Propranolol-Mediated β-Blockade.
- Chow W1, Amaya CN2, Rains S2, Chow M1, Dickerson EB3, Bryan BA2.
- JAMA dermatology.JAMA Dermatol.2015 Nov;151(11):1226-9. doi: 10.1001/jamadermatol.2015.2554.
- IMPORTANCE: Patients with stage T2 multilesion angiosarcomas of the scalp and face that are larger than 10 cm demonstrate a 2-year survival rate of 0%. To our knowledge, major therapeutic advances against this disease have not been reported for decades. Preclinical data indicate that blocking β-adr
- PMID 26375166
- Longitudinal DSC-MRI for Distinguishing Tumor Recurrence From Pseudoprogression in Patients With a High-grade Glioma.
- Boxerman JL1, Ellingson BM, Jeyapalan S, Elinzano H, Harris RJ, Rogg JM, Pope WB, Safran H.
- American journal of clinical oncology.Am J Clin Oncol.2014 Nov 26. [Epub ahead of print]
- OBJECTIVE:: For patients with high-grade glioma on clinical trials it is important to accurately assess time of disease progression. However, differentiation between pseudoprogression (PsP) and progressive disease (PD) is unreliable with standard magnetic resonance imaging (MRI) techniques. Dynamic
- PMID 25436828
Japanese Journal
- 化学療法歴のないPS2の進行非小細胞肺癌患者の治療におけるpaclitaxel poliglumex(CT-2103、PPX)+カルボプラチン併用療法vsパクリタキセル標準製剤+カルボプラチン併用療法の第3相比較試験
Related Links
- Paclitaxel poliglumex is a biologically enhanced chemotherapeutic that links paclitaxel, the active ingredient in Taxol, to a biodegradable polyglutamate polymer, resulting in a new chemical entity (NCE). ... About paclitaxel poliglumex ...
- Paclitaxel is a widely used chemotherapeutic agent; however, its therapeutic index is limited by low tumor exposure and high systemic exposure. Paclitaxel poliglumex (PPX) is macromolecular drug conjugate that links ...
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- 英
- paclitaxel poliglumex
- 関
- パクリタキセル・リグルメクス