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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/15 18:58:30」(JST)

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Oxypertine (Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil) is an antipsychotic used in the treatment of schizophrenia.^[1] Chemically, it is an indole derivative similarly to molindone and a member of the phenylpiperazine class.^[2] Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly underlying its neuroleptic efficacy.^[3]

References

^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. http://books.google.com/?id=5S_uhYzKWisC&lpg=PA5038&dq=oxypertine%20forit&pg=PA5038#v=onepage&q=.
^ Breulet M, Labar P, Delree C, Collard J, Bobon J (February 1968). "[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties]" (in French). Acta Neurol Psychiatr Belg 68 (2): 116–27. PMID 4972600.
^ Bak IJ, Hassler R, Kim JS (1969). "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin". Zeitschrift Für Zellforschung Und Mikroskopische Anatomie (Vienna, Austria : 1948) 101 (3): 448–62. PMID 5362847.

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English Journal

Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain.

Oka T, Hamamura T, Lee Y, Miyata S, Habara T, Endo S, Taoka H, Kuroda S.SourceDepartment of Neuropsychiatry, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. toka@md.okayama-u.ac.jp
Life sciences.Life Sci.2004 Nov 26;76(2):225-37.
Acute administration of typical and atypical antipsychotics has been reported to induce regionally distinct patterns of c-Fos expression in the rat forebrain. Furthermore, atypical index, the difference in the extent of increased Fos-like immunoreactivity (Fos-LI) in the nucleus accumbens (NAc) shel
PMID 15519367

Towards pick-and-place assembly of nanostructures.

Mølhave K, Hansen TM, Madsen DN, Bøggild P.SourceDepartment of Micro and Nanotechnology, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Journal of nanoscience and nanotechnology.J Nanosci Nanotechnol.2004 Mar;4(3):279-82.
We examine an approach to three-dimensional pick-and-place assembly of wire-like nanoscale components, such as carbon nanotubes and silicon nanowires, on microstructures inside a scanning electron microscope. In this article we demonstrate that microfabricated electrostatically acutuated tweezers ca
PMID 15233090

Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.

Staack RF, Maurer HH.SourceDepartment of Experimental and Clinical Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2003 Dec 25;798(2):333-42.
Studies are described on the toxicological analysis of the piperazine-derived designer drug 1-(4-methoxyphenyl)piperazine (MeOPP) in rat urine using gas chromatography-mass spectrometry (GC-MS). The authors' systematic toxicological analysis (STA) procedure using full-scan GC-MS after acid hydrolysi
PMID 14643514

Japanese Journal

精神病院入院患者の血漿中抗精神病薬濃度

徳永仁伯,工藤恵子,今村徹 [他],實淵成美,大塚幸,池田典昭
日本法医学雑誌 = THE JAPANESE JOURNAL OF LEGAL MEDICINE 51(6), 417-422, 1997-12-10
NAID 10016331513

Synthesis of Several 3-Substituted 2-Trifluoromethylindoles via Mannich Reaction of 2-Trifluoromethylindoles

Miyashita Kazuyuki,Kondoh Katsunori,Tsuchiya Katsutoshi [他],MIYABE Hideto,IMANISHI Takeshi
Chemical & pharmaceutical bulletin 45(5), 932-935, 1997-05-15
… Several 2-trifluoromethyl derivatives of biologically active indoles, tryptamine, indole-3-acetic acid, oxypertine and tryptophan, were synthesized starting from 2-trifluoromethylindoles by use of the Mannich reaction and subsequent nucleophilic substitution reaction as key steps. …
NAID 110003616594

Synthesis of Several 3-Substituted 2-Trifluoromethylinodoles via Mannich Reaction of 2-Trifluoromethylindoles.

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Chemical and Pharmaceutical Bulletin 45(5), 932-935, 1997
… Several 2-trifluoromethyl derivatives of biologically active indoles, tryptamine, indole-3-acetic acid, oxypertine and tryptophan, were synthesized starting from 2-trifluoromethylindoles by use of the Mannich reaction and subsequent nucleophilic substitution reaction as key steps. …
NAID 130003773740

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Oxypertine
Systematic (IUPAC) name
	5,6-dimethoxy-2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	153-87-7
ATC code	N05AE01
PubChem	CID 4640
UNII	5JGL4G25R7
KEGG	D01219
Chemical data
Formula	C23H29N3O2
Mol. mass	379.49 g/mol
	SMILES CC1=C(C2=CC(=C(C=C2N1)OC)OC)CCN3CCN(CC3)C4=CC=CC=C4;
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英: oxypertine
商: ホーリット

[isbn0-412-54090-8-1] Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. http://books.google.com/?id=5S_uhYzKWisC&lpg=PA5038&dq=oxypertine%20forit&pg=PA5038#v=onepage&q=.

[pmid4972600-2] Breulet M, Labar P, Delree C, Collard J, Bobon J (February 1968). "[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties]" (in French). Acta Neurol Psychiatr Belg 68 (2): 116–27. PMID 4972600.

[pmid5362847-3] Bak IJ, Hassler R, Kim JS (1969). "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin". Zeitschrift Für Zellforschung Und Mikroskopische Anatomie (Vienna, Austria : 1948) 101 (3): 448–62. PMID 5362847.

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oxypertine