酸素化ヘモグロビン
WordNet
- a hemoprotein composed of globin and heme that gives red blood cells their characteristic color; function primarily to transport oxygen from the lungs to the body tissues; "fish have simpler hemoglobin than mammals" (同)haemoglobin, Hb
- impregnate, combine, or supply with oxygen; "oxygenate blood" (同)oxygenize, oxygenise, aerate
PrepTutorEJDIC
- ヘモグロビン,血色素
- …‘に'酸素を与える,‘を'酸素で処理する
UpToDate Contents
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English Journal
- Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals.
- Nishimura Y, Takizawa R, Koike S, Kinoshita A, Satomura Y, Kawasaki S, Yamasue H, Tochigi M, Kakiuchi C, Sasaki T, Iwayama Y, Yamada K, Yoshikawa T, Kasai K.Author information Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Department of Youth Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: ynishimu-mie@umin.ac.jp.AbstractThe early growth response 3 (EGR3) gene is an immediate early gene that is expressed throughout the brain and has been suggested as a potential susceptibility gene for schizophrenia (SZ). EGR3 impairment is associated with various neurodevelopmental dysfunctions, and some animal studies have reported a role for EGR3 function in the prefrontal cortex. Therefore, EGR3 genotype variation may be reflected in prefrontal function. By using multi-channel near-infrared spectroscopy (NIRS) in an imaging genetics approach, we tested for an association between the EGR3 gene polymorphism and prefrontal hemodynamic response during a cognitive task in patients with SZ. We assessed 73 chronic patients with SZ and 73 age-, gender-, and genotype-matched healthy controls (HC) who provided written informed consent. We used NIRS to measure changes in prefrontal oxygenated hemoglobin concentration (oxyHb) during the letter version of a verbal fluency task (VFT). Statistical comparisons were performed among EGR3 genotype subgroups (rs35201266, GG/GA/AA). The AA genotype group showed significantly smaller oxyHb increases in the left dorsolateral prefrontal cortex (DLPFC) during the VFT than the GG and GA genotype groups; this was true for both patients with SZ and HC. Our findings provide in vivo human evidence of a significant influence of EGR3 polymorphisms on prefrontal hemodynamic activation level in healthy adults and in patients with SZ. Genetic variation in EGR3 may affect prefrontal function through neurodevelopment. This study illustrates the usefulness of NIRS in imaging genetics investigations on psychiatric disorders.
- NeuroImage.Neuroimage.2014 Jan 15;85 Pt 1:527-34. doi: 10.1016/j.neuroimage.2013.08.021. Epub 2013 Aug 17.
- The early growth response 3 (EGR3) gene is an immediate early gene that is expressed throughout the brain and has been suggested as a potential susceptibility gene for schizophrenia (SZ). EGR3 impairment is associated with various neurodevelopmental dysfunctions, and some animal studies have reporte
- PMID 23962955
- Show me how you walk and I tell you how you feel - A functional near-infrared spectroscopy study on emotion perception based on human gait.
- Schneider S, Christensen A, Häußinger FB, Fallgatter AJ, Giese MA, Ehlis AC.Author information University Clinic of Psychiatry and Psychotherapy, Department of General Psychiatry, University of Tuebingen, 72076, Germany. Electronic address: S.Schneider@med.uni-tuebingen.de.AbstractThe ability to recognize and adequately interpret emotional states in others plays a fundamental role in regulating social interaction. Body language presents an essential element of nonverbal communication which is often perceived prior to mimic expression. However, the neural networks that underlie the processing of emotionally expressive body movement and body posture are poorly understood. 33 healthy subjects have been investigated using the optically based imaging method functional near-infrared spectroscopy (fNIRS) during the performance of a newly developed emotion discrimination paradigm consisting of faceless avatars expressing fearful, angry, sad, happy or neutral gait patterns. Participants were instructed to judge (a) the presented emotional state (emotion task) and (b) the observed walking speed of the respective avatar (speed task). We measured increases in cortical oxygenated haemoglobin (O2HB) in response to visual stimulation during emotion discrimination. These O2HB concentration changes were enhanced for negative emotions in contrast to neutral gait sequences in right occipito-temporal and left temporal and temporo-parietal brain regions. Moreover, fearful and angry bodies elicited higher activation increases during the emotion task compared to the speed task. Haemodynamic responses were correlated with a number of behavioural measures, whereby a positive relationship between emotion regulation strategy preference and O2HB concentration increases after sad walks was mediated by the ability to accurately categorize sad walks. Our results support the idea of a distributed brain network involved in the recognition of bodily emotion expression that comprises visual association areas as well as body/movement perception specific cortical regions that are also sensitive to emotion. This network is activated less when the emotion is not intentionally processed (i.e. during the speed task). Furthermore, activity of this perceptive network is, mediated by the ability to correctly recognize emotions, indirectly connected to active emotion regulation processes. We conclude that a full understanding of emotion perception and its neural substrate requires the investigation of dynamic representations and means of expression other than the face.
- NeuroImage.Neuroimage.2014 Jan 15;85 Pt 1:380-90. doi: 10.1016/j.neuroimage.2013.07.078. Epub 2013 Aug 3.
- The ability to recognize and adequately interpret emotional states in others plays a fundamental role in regulating social interaction. Body language presents an essential element of nonverbal communication which is often perceived prior to mimic expression. However, the neural networks that underli
- PMID 23921096
- Interleaved imaging of cerebral hemodynamics and blood flow index to monitor ischemic stroke and treatment in rat by volumetric diffuse optical tomography.
- Lin ZJ, Ren M, Li L, Liu Y, Su J, Yang SH, Liu H.Author information Department of Bioengineering, Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center, University of Texas at Arlington, TX 76019, USA.AbstractDiffuse optical tomography (DOT) has been used by several groups to assess cerebral hemodynamics of cerebral ischemia in humans and animals. In this study, we combined DOT with an indocyanine green (ICG)-tracking method to achieve interleaved images of cerebral hemodynamics and blood flow index (BFI) using two middle cerebral artery occlusion (MCAO) rat models. To achieve volumetric images with high-spatial resolution, we first integrated a depth compensation algorithm (DCA) with a volumetric mesh-based rat head model to generate three-dimensional (3D) DOT on a rat brain atlas. Then, the experimental DOT data from two rat models were collected using interleaved strategy for cerebral hemodynamics and BFI during and after ischemic stroke, with and without a thrombolytic therapy for the embolic MCAO model. The acquired animal data were further analyzed using the integrated rat-atlas-guided DOT method to form time-evolving 3D images of both cerebral hemodynamics and BFI. In particular, we were able to show and identify therapeutic outcomes of a thrombolytic treatment applied to the embolism-induced ischemic model. This paper demonstrates that volumetric DOT is capable of providing high-quality, interleaved images of cerebral hemodynamics and blood perfusion in small animals during and after ischemic stroke, with excellent 3D visualization and quantifications.
- NeuroImage.Neuroimage.2014 Jan 15;85 Pt 1:566-82. doi: 10.1016/j.neuroimage.2013.07.020. Epub 2013 Jul 16.
- Diffuse optical tomography (DOT) has been used by several groups to assess cerebral hemodynamics of cerebral ischemia in humans and animals. In this study, we combined DOT with an indocyanine green (ICG)-tracking method to achieve interleaved images of cerebral hemodynamics and blood flow index (BFI
- PMID 23872158
Japanese Journal
- Estimation of Melanin and Hemoglobin Using Spectral Reflectance Images Reconstructed from a Digital RGB Image by the Wiener Estimation Method
- Nishidate Izumi,Maeda Takaaki,Niizeki Kyuichi,Aizu Yoshihisa
- Sensors 13(6), 7902-7915, 2013-06-19
- … Using the resultant absorbance spectrum as a response variable and the extinction coefficients of melanin, oxygenated hemoglobin and deoxygenated hemoglobin as predictor variables, multiple regression analysis provides regression coefficients. …
- NAID 120005323273
- Comparison of Oscillation of Oxygenation in Skeletal Muscle Between Early and Late Phases in Prolonged Exercise
- T. YANO,C.-S. LIAN,T. ARIMITSU,R. YAMANAKA,R. AFROUNDEH,K. SHIRAKAWA,T. YUNOKI
- Physiological Research 62(3), 297-304, 2013-06
- … During prolonged exercise at 60 % of peak oxygen uptake ( Vo2) for 60 min and at rest, oxygenated hemoglobin/myoglobin (Hb/MbO2) and total Hb/Mb (THb/Mb) were determined by near-infrared spectroscopy in the vastus lateralis. …
- NAID 120005303472
- Oscillation of oxygenation in skeletal muscle at rest and in light exercise
- T Yano,C-S Lian,T Arimitsu,R Yamanaka,R Afroundeh,K Shirakawa,T Yunoki
- Acta physiologica Hungarica 100, 312-320, 2013-05-16
- … A subject rested in a recumbent position for 5 min and changed body position to a sitting position on a cycle ergometer for 9 min. Then exercise with low intensity (work rate of 60% of maximal oxygen uptake) was carried out for 30 min. Total hemoglobin and myoglobin (THb/Mb) suddenly decreased after the start of exercise and gradually increased until 6 min. Oxygenated hemoglobin and myoglobin (Hb/MbO2) suddenly decreased and returned to a steady state after the start of exercise. …
- NAID 120005303473
Related Links
- The oxygen-carrying protein hemoglobin was discovered by Hünefeld in 1840. In 1851, Otto Funke published a series of articles in which he described growing hemoglobin crystals by successively diluting red blood cells with a solvent such ...
★リンクテーブル★
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- 英
- oxyhemoglobin (SP), oxygenated hemoglobin, O2Hb
- 同
- オキシヘモグロビン、酸化ヘモグロビン
- 関
- ヘモグロビン、メトヘモグロビン、酸素容量
[show details]
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- 関
- oxygenated、oxygenation
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- 関
- oxygenate、oxygenation
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ヘモグロビン