関: oxyfedrine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/16 23:50:11」(JST)

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Oxyfedrine is a vasodilator. Oxyfedrine was found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotrophic effects, thereby not precipitating angina pectoris. The latter property (positive chronotropic and inotrophic effects) is particularly important, because other vasodilators used in angina may be counter productive causing coronary steal phenomenon.

Synergestic effects with antibiotics have been suggested.^[1]

References

^ Mazumdar K, Dutta NK, Kumar KA, Dastidar SG (April 2005). "In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains" (^{[dead link]}). Biol. Pharm. Bull. 28 (4): 713–7. doi:10.1248/bpb.28.713. PMID 15802815.

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English Journal

Physiological changes induced by chromium stress in plants: an overview.

Hayat S1, Khalique G, Irfan M, Wani AS, Tripathi BN, Ahmad A.
Protoplasma.Protoplasma.2012 Jul;249(3):599-611. doi: 10.1007/s00709-011-0331-0. Epub 2011 Oct 16.
This article presents an overview of the mechanism of chromium (Cr) stress in plants. Toxic effects of Cr on plant growth and development depend primarily on its valence state. Cr(VI) is highly toxic and mobile whereas Cr(III) is less toxic. Cr-induced oxidative stress involves induction of lipid pe
PMID 22002742

Potential role of the cardiovascular non-antibiotic (helper compound) amlodipine in the treatment of microbial infections: scope and hope for the future.

Mazumdar K1, Asok Kumar K, Dutta NK.
International journal of antimicrobial agents.Int J Antimicrob Agents.2010 Oct;36(4):295-302. doi: 10.1016/j.ijantimicag.2010.05.003. Epub 2010 Jun 29.
The appearance of multiresistant bacterial strains coupled with the globally ongoing problem of infectious diseases point to the imperative need for novel and affordable antimicrobial drugs. The antibacterial potential of cardiovascular non-antibiotics such as amlodipine (AML), dobutamine, lacidipin
PMID 20591629

Rational drug correction of systemic inflammatory response syndrome in severe experimental heart failure.

Sukoyan GV1, Antelava NA.
Bulletin of experimental biology and medicine.Bull Exp Biol Med.2009 Apr;147(4):411-4.
A course of adenocine (cardiotonic drug with a pronounced cardioprotective effect) for severe experimental heart failure caused by toxic allergic myocarditis (for 10 days) more effectively restored the systolic and diastolic function of the heart and arrested systemic inflammatory response syndrome
PMID 19704936

Japanese Journal

In Vitro and In Vivo Synergism between Tetracycline and the Cardiovascular Agent Oxyfedrine HCl against Common Bacterial Strains(Miscellaneous)

MAZUMDAR Kaushiki,DUTTA Noton Kumar,KUMAR Kuppusamy Asok,DASTIDAR Sujata Ghosh
Biological & pharmaceutical bulletin 28(4), 713-717, 2005-04-01
… The cardiovascular drug oxyfedrine HCl revealed noteworthy in vitro antibacterial action against 501 strains of Gram positive and Gram negative bacteria. … For this purpose, ten bacterial strains were selected, which were sensitive to oxyfedrine as well as to six antibiotics, like benzyl penicillin, chloramphenicol, ciprofloxacin, erythromycin, streptomycin and tetracycline. …
NAID 10016662520

EFFECT OF CORONARY VASODILATORS ON CARDIAC DYNAMICS OF THE NORMAL DOG AND THE DOG WITH EXPERIMENTAL CORONARY SCLEROSIS

SAITO DAIJI
日本循環器学誌 40(4), 363-397, 1976-05-20
… Observations are presented about the effects of four kinds of coronary vasodilators (dipyridamole, oxyfedrine, prenylamine and trimetazidine) on coronary circulation in the heart with coronary sclerosis which has been induced by intravenous injection of allylamine in the dog. …
NAID 110002599556

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★リンクテーブル★

リンク元	「オキシフェドリン」
拡張検索	「oxyfedrine hydrochloride」

「オキシフェドリン」

Oxyfedrine
Systematic (IUPAC) name
	(RS)-3-[(2-Hydroxy-1-methyl-2-phenylethyl)amino]-1-(3-methoxyphenyl)propan-1-one
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	15687-41-9
ATC code	C01DX03
PubChem	CID 27454
UNII	DWL616XF1K
KEGG	D08321
Chemical data
Formula	C19H23NO3
Mol. mass	313.39 g/mol
	SMILES COc1cc(ccc1)C(=O)CCNC(C)C(O)c2ccccc2;
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