オキシフェドリン
- 関
- oxyfedrine hydrochloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/08/16 23:50:11」(JST)
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Oxyfedrine
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Systematic (IUPAC) name |
(RS)-3-[(2-Hydroxy-1-methyl-2-phenylethyl)amino]-1-(3-methoxyphenyl)propan-1-one |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
? |
Identifiers |
CAS number |
15687-41-9 Y |
ATC code |
C01DX03 |
PubChem |
CID 27454 |
UNII |
DWL616XF1K Y |
KEGG |
D08321 Y |
Chemical data |
Formula |
C19H23NO3 |
Mol. mass |
313.39 g/mol |
SMILES
- COc1cc(ccc1)C(=O)CCNC(C)C(O)c2ccccc2
|
Y (what is this?) (verify) |
Oxyfedrine is a vasodilator. Oxyfedrine was found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotrophic effects, thereby not precipitating angina pectoris. The latter property (positive chronotropic and inotrophic effects) is particularly important, because other vasodilators used in angina may be counter productive causing coronary steal phenomenon.
Synergestic effects with antibiotics have been suggested.[1]
References
- ^ Mazumdar K, Dutta NK, Kumar KA, Dastidar SG (April 2005). "In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains" ([dead link]). Biol. Pharm. Bull. 28 (4): 713–7. doi:10.1248/bpb.28.713. PMID 15802815.
Adrenergics
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Receptor ligands
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α1
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α2
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- Agonists: (R)-3-Nitrobiphenyline
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Antagonists: 1-PP
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* Note that many atypical antipsychotics and azapirones like buspirone (via metabolite 1-PP) antagonize α2-adrenergic receptors as well.
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β
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Reuptake inhibitors
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NET
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- Selective norepinephrine reuptake inhibitors: Amedalin
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- DOV-216,303
- JNJ-7925476
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- SEP-225,289
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VMAT
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- Ibogaine
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Enzyme inhibitors
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Anabolism
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PAH
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TH
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AAAD
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DBH
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PNMT
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- CGS-19281A
- SKF-64139
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Catabolism
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MAO
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- Nonselective: Benmoxin
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* Note that MAO-B inhibitors also influence norepinephrine/epinephrine levels since they inhibit the breakdown of their precursor dopamine.
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COMT
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- Entacapone
- Nitecapone
- Tolcapone
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Others
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Precursors
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- L-Phenylalanine → L-Tyrosine → L-DOPA (Levodopa) → Dopamine
- L-DOPS (Droxidopa)
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Cofactors
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- Ferrous Iron (Fe2+)
- S-Adenosyl-L-Methionine
- Vitamin B3 (Niacin
- Nicotinamide → NADPH)
- Vitamin B6 (Pyridoxine
- Pyridoxamine
- Pyridoxal → Pyridoxal Phosphate)
- Vitamin B9 (Folic acid → Tetrahydrofolic acid)
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Others
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- Activity enhancers: BPAP
- PPAP; Release blockers: Bethanidine
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List of adrenergic drugs
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Vasodilators used in cardiac diseases (C01D)
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Nitrovasodilators |
- Nitroglycerin #
- Isosorbide dinitrate #
- Isosorbide mononitrate
- Linsidomine
- Molsidomine
- Nicorandil
- Pentaerythritol tetranitrate
- Propatylnitrate
- Tenitramine
- Trolnitrate
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Quinolone vasodilators |
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Others |
- Benziodarone
- Carbocromen
- Cinepazet
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- Dilazep
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- Etafenone
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- Levosimendan
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- Oxyfedrine
- Pimobendan
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- Serelaxin
- Trapidil
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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noco/cong/tumr, sysi/epon, injr
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proc, drug (C1A/1B/1C/1D), blte
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English Journal
- Physiological changes induced by chromium stress in plants: an overview.
- Hayat S1, Khalique G, Irfan M, Wani AS, Tripathi BN, Ahmad A.
- Protoplasma.Protoplasma.2012 Jul;249(3):599-611. doi: 10.1007/s00709-011-0331-0. Epub 2011 Oct 16.
- This article presents an overview of the mechanism of chromium (Cr) stress in plants. Toxic effects of Cr on plant growth and development depend primarily on its valence state. Cr(VI) is highly toxic and mobile whereas Cr(III) is less toxic. Cr-induced oxidative stress involves induction of lipid pe
- PMID 22002742
- Potential role of the cardiovascular non-antibiotic (helper compound) amlodipine in the treatment of microbial infections: scope and hope for the future.
- Mazumdar K1, Asok Kumar K, Dutta NK.
- International journal of antimicrobial agents.Int J Antimicrob Agents.2010 Oct;36(4):295-302. doi: 10.1016/j.ijantimicag.2010.05.003. Epub 2010 Jun 29.
- The appearance of multiresistant bacterial strains coupled with the globally ongoing problem of infectious diseases point to the imperative need for novel and affordable antimicrobial drugs. The antibacterial potential of cardiovascular non-antibiotics such as amlodipine (AML), dobutamine, lacidipin
- PMID 20591629
- Rational drug correction of systemic inflammatory response syndrome in severe experimental heart failure.
- Sukoyan GV1, Antelava NA.
- Bulletin of experimental biology and medicine.Bull Exp Biol Med.2009 Apr;147(4):411-4.
- A course of adenocine (cardiotonic drug with a pronounced cardioprotective effect) for severe experimental heart failure caused by toxic allergic myocarditis (for 10 days) more effectively restored the systolic and diastolic function of the heart and arrested systemic inflammatory response syndrome
- PMID 19704936
Japanese Journal
- In Vitro and In Vivo Synergism between Tetracycline and the Cardiovascular Agent Oxyfedrine HCl against Common Bacterial Strains(Miscellaneous)
- MAZUMDAR Kaushiki,DUTTA Noton Kumar,KUMAR Kuppusamy Asok,DASTIDAR Sujata Ghosh
- Biological & pharmaceutical bulletin 28(4), 713-717, 2005-04-01
- … The cardiovascular drug oxyfedrine HCl revealed noteworthy in vitro antibacterial action against 501 strains of Gram positive and Gram negative bacteria. … For this purpose, ten bacterial strains were selected, which were sensitive to oxyfedrine as well as to six antibiotics, like benzyl penicillin, chloramphenicol, ciprofloxacin, erythromycin, streptomycin and tetracycline. …
- NAID 10016662520
- EFFECT OF CORONARY VASODILATORS ON CARDIAC DYNAMICS OF THE NORMAL DOG AND THE DOG WITH EXPERIMENTAL CORONARY SCLEROSIS
- SAITO DAIJI
- 日本循環器学誌 40(4), 363-397, 1976-05-20
- … Observations are presented about the effects of four kinds of coronary vasodilators (dipyridamole, oxyfedrine, prenylamine and trimetazidine) on coronary circulation in the heart with coronary sclerosis which has been induced by intravenous injection of allylamine in the dog. …
- NAID 110002599556
Related Links
- Definition of oxyfedrine in the Definitions.net dictionary. Meaning of oxyfedrine. What does oxyfedrine mean? Information and translations of oxyfedrine in the most comprehensive dictionary definitions resource on the web.
- Oxyfedrine information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Oxyfedrine Description of Oxyfedrine Oxyfedrine: A drug used in the treatment of angina ...
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★リンクテーブル★
[★]
- 英
- oxyfedrine、oxyfedrine hydrochloride
- 関
- 塩酸オキシフェドリン
[★]
- 関
- oxyfedrine