- 酸化しうる
WordNet
- capable of undergoing a chemical reaction with oxygen
- the process of oxidizing; the addition of oxygen to a compound with a loss of electrons; always occurs accompanied by reduction (同)oxidization, oxidisation
- add oxygen to or combine with oxygen (同)oxidise, oxidate
PrepTutorEJDIC
- 酸化
English Journal
- Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2.
- Tyurin VA1, Balasubramanian K1, Winnica D1, Tyurina YY1, Vikulina AS2, He RR3, Kapralov AA1, Macphee CH4, Kagan VE1.Author information 11] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.21] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA [3] Department of Biophysics, MV Lomonosov Moscow State University, Moscow, Russia.31] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [2] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA [3] Pharmacy College, Jinan University, Guangzhou, China.4GlaxoSmithKline, King of Prussia, PA, USA.AbstractDiversified anionic phospholipids, phosphatidylserines (PS), externalized to the surface of apoptotic cells are universal phagocytic signals. However, the role of major PS metabolites, such as peroxidized species of PS (PSox) and lyso-PS, in the clearance of apoptotic cells has not been rigorously evaluated. Here, we demonstrate that H2O2 was equally effective in inducing apoptosis and externalization of PS in naive HL60 cells and in cells enriched with oxidizable polyunsaturated species of PS (supplemented with linoleic acid (LA)). Despite this, the uptake of LA-supplemented cells by RAW264.7 and THP-1 macrophages was more than an order of magnitude more effective than that of naive cells. A similar stimulation of phagocytosis was observed with LA-enriched HL60 cells and Jurkat cells triggered to apoptosis with staurosporine. This was due to the presence of PSox on the surface of apoptotic LA-supplemented cells (but not of naive cells). This enhanced phagocytosis was dependent on activation of the intrinsic apoptotic pathway, as no stimulation of phagocytosis occurred in LA-enriched cells challenged with Fas antibody. Incubation of apoptotic cells with lipoprotein-associated phospholipase A2 (Lp-PLA2), a secreted enzyme with high specificity towards PSox, hydrolyzed peroxidized PS species in LA-supplemented cells resulting in the suppression of phagocytosis to the levels observed for naive cells. This suppression of phagocytosis by Lp-PLA2 was blocked by a selective inhibitor of Lp-PLA2, SB-435495. Screening of possible receptor candidates revealed the ability of several PS receptors and bridging proteins to recognize both PS and PSox, albeit with diverse selectivity. We conclude that PSox is an effective phagocytic 'eat-me' signal that participates in the engulfment of cells undergoing intrinsic apoptosis.
- Cell death and differentiation.Cell Death Differ.2014 May;21(5):825-35. doi: 10.1038/cdd.2014.1. Epub 2014 Jan 24.
- Diversified anionic phospholipids, phosphatidylserines (PS), externalized to the surface of apoptotic cells are universal phagocytic signals. However, the role of major PS metabolites, such as peroxidized species of PS (PSox) and lyso-PS, in the clearance of apoptotic cells has not been rigorously e
- PMID 24464221
- A mild, ferrocene-catalyzed C-h imidation of (hetero)arenes.
- Foo K1, Sella E, Thomé I, Eastgate MD, Baran PS.Author information 1Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.AbstractA simple method for direct C-H imidation is reported using a new perester-based self-immolating reagent and a base-metal catalyst. The succinimide products obtained can be easily deprotected in situ (if desired) to reveal the corresponding anilines directly. The scope of the reaction is broad, the conditions are extremely mild, and the reaction is tolerant of oxidizable and acid-labile functionality, multiple heteroatoms, and aryl iodides. Mechanistic studies indicate that ferrocene (Cp2Fe) plays the role of an electron shuttle in the decomposition of the perester reagent, delivering a succinimidyl radical ready to add to an aromatic system.
- Journal of the American Chemical Society.J Am Chem Soc.2014 Apr 9;136(14):5279-82. doi: 10.1021/ja501879c. Epub 2014 Mar 31.
- A simple method for direct C-H imidation is reported using a new perester-based self-immolating reagent and a base-metal catalyst. The succinimide products obtained can be easily deprotected in situ (if desired) to reveal the corresponding anilines directly. The scope of the reaction is broad, the c
- PMID 24654983
- Reactivities and products of free radical oxidation of cholestadienols.
- Xu L1, Porter NA.Author information 1Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37235, United States.Abstract7-Dehydrocholesterol (7-DHC) is the most oxidizable lipid molecule reported to date, with a propagation rate constant for free radical peroxidation that is 200 times that of cholesterol. To better understand the high reactivity of 7-DHC and elucidate the reaction mechanism, we synthesized conjugated and skipped nonconjugated cholestadienols that would give one of the two putative pentadienyl-radical intermediates formed in 7-DHC peroxidation. The additional dienols include 6,8(9)-dienol, 5,8(14)-dienol, 6,8(14)-dienol, and the biologically important 8-dehydrocholesterol (8-DHC; 5,8(9)-dienol). We found that all of the dienols are significantly (at least 40 times) more reactive than cholesterol. Among them, dienols leading to the formation of the pentadienyl radical in ring B (termed endo-B) of the sterol are more reactive than those leading to the pentadienyl radical spanning rings B and C (termed exo-B). By comparing the oxysterol profile formed from 7-DHC and those formed from 8-DHC and 5,8(14)-dienol, products formed from abstraction of the hydrogen atoms at C-9 and C-14 (H-9 or H-14 mechanism) were clearly differentiated. When the oxidation was carried out in the presence of the good hydrogen atom donor α-tocopherol, the oxysterol profile of 7-DHC peroxidation differed distinctly from the profile observed in the absence of the antioxidant and resembles more closely the profile observed in biological systems. This study suggests that oxidative stress and the accumulation of oxysterols should be considered as two key factors in cholesterol biosynthesis or metabolism disorders, where dienyl sterol intermediates are accumulated.
- Journal of the American Chemical Society.J Am Chem Soc.2014 Apr 9;136(14):5443-50. doi: 10.1021/ja5011674. Epub 2014 Mar 26.
- 7-Dehydrocholesterol (7-DHC) is the most oxidizable lipid molecule reported to date, with a propagation rate constant for free radical peroxidation that is 200 times that of cholesterol. To better understand the high reactivity of 7-DHC and elucidate the reaction mechanism, we synthesized conjugated
- PMID 24625033
Japanese Journal
- Low temperature activation of Au/Ti getter film for application to wafer-level vacuum packaging
- Wu Ming,Moulin Johan,Lani Sébastien,Hallais Géraldine,Renard Charles,Bosseboeuf Alain
- Jpn. J. Appl. Phys. 54(3), 030220, 2015-01-28
- … In this work we investigate the potential of Au/Ti system with a thin or ultrathin non oxidizable Au layer as a low activation temperature getter material. …
- NAID 150000110175
- Feasibility of Bioleaching in Removing Metals (Al, Ni, V and Mo) from as Received Raw Petroleum Spent Refinery Catalyst: A Comparative Study on Leaching Yields, Risk Assessment Code and Reduced Partition Index
- Pathak Ashish,Srichandan Haragobinda,Kim Dong-Jin
- MATERIALS TRANSACTIONS 56(8), 1278-1286, 2015
- … thiooxidans, the remaining metals in the bioleached spent catalyst samples were present in stable forms (oxidizable and residual fractions). …
- NAID 130005088971
- Oxidized DJ-1 as a possible biomarker of Parkinson's disease
- Saito Yoshiro
- Journal of Clinical Biochemistry and Nutrition 54(3), 138-144, 2014
- … This review focuses on the role of DJ-1 in antioxidative defense and the importance of oxidizable Cys-106 in its function. …
- NAID 130004466748
Related Links
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Related Pictures
★リンクテーブル★
| リンク元 | 「oxidize」「oxidised」「oxidation」「oxidization」 |
「oxidize」
- 酸化する
「oxidised」
酸化された
「oxidation」