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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/26 21:34:14」(JST)
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Oxaceprol
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| Systematic (IUPAC) name |
| (4R)-1-acetyl-4-hydroxy-L-proline |
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Pregnancy cat. |
? |
| Legal status |
? |
| Identifiers |
| CAS number |
33996-33-7 Y |
| ATC code |
D11AX09 M01AX24 |
| PubChem |
CID 65784 |
| UNII |
Q0XV76B96L Y |
| KEGG |
D07215 Y |
| Synonyms |
(2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid |
| Chemical data |
| Formula |
C7H11NO4 |
| Mol. mass |
172.159 g/mol |
Y (what is this?) (verify)
|
Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.[1] It is derived from L-proline, a DNA-encoded amino acid. The active effect of Oxaceprol is to inhibit the adhesion and migration of white blood cells.[2]
References[edit]
- ^ Herrmann G, Steeger D, Klasser M et al. (2000). "Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac". Clin. Rheumatol. 19 (2): 99–104. doi:10.1007/s100670050025. PMID 10791619.
- ^ Clayton, James J. (August 2007), "Nutraceuticals in the Management of Osteoarthritis", Orthopedics 30 (8), retrieved 2013-06-08.
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Other dermatological preparations (D11)
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| Medicated shampoos |
- Cetrimide
- Cadmium compounds
- Selenium compounds
- Povidone-iodine
- Sulfur compounds
- Xenysalate
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| Other dermatologicals |
| Seborrhoeic dermatitis/dandruff |
- Lithium succinate
- Pyrithione zinc
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| Skin whitening/depigmenting |
- Hydroquinone
- Mequinol
- Monobenzone
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| Anti-inflammatory/Immunomodulators |
- Oxaceprol
- Gamolenic acid
- Pimecrolimus
- Tacrolimus
- Alitretinoin
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| Baldness treatments |
- 5-alpha-reductase inhibitors
- potassium channel opener
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| Hair growth inhibitors |
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| Other |
- Calcium gluconate
- Magnesium sulfate
- Tiratricol
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noco (i/b/d/q/u/r/p/m/k/v/f)/cong/tumr (n/e/d), sysi/epon
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proc, drug (D2/3/4/5/8/11)
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noco/cong/tumr, sysi/epon
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English Journal
- A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials.
- Pavelka K.SourceInstitute of Rheumatology and Clinic of Rheumatology, Charles University, Prague, Czech Republic. pavelka@revma.cz
- Current medical research and opinion.Curr Med Res Opin.2012 Jan;28(1):163-78.
- OBJECTIVE: Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) commonly prescribed for pain relief in osteoarthritis (OA). The relative efficacy of diclofenac compared to other pain relief medications used in OA (e.g., alternative NSAIDs, cyclooxygenase type 2 [COX-2] inhibitors) is uncertai
- PMID 22168216
- Determination of oxaceprol in rat plasma by LC-MS/MS and its application in a pharmacokinetic study.
- Gu J, Chen N, Ding G, Zhang Z.SourceDepartment of Pharmacy, Eye & ENT Hospital of Fudan University, Shanghai 200031, China. gujifeng1949@126.com
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2011 Jan 5;54(1):173-8. Epub 2010 Aug 19.
- A sensitive method for the quantification of oxaceprol in rat plasma using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed. Sample pretreatment involved a simple protein precipitation by the addition of 60 μL of acetonitrile-methanol (1:2, v/v) to 20 μL pla
- PMID 20832228
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