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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/20 17:19:12」(JST)

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Latamoxef

Flomoxef

An oxacephem is a molecule similar to a cephem, but with oxygen substituted for the sulfur. They are synthetic compounds not seen in nature. Examples include moxalactam^[1] and flomoxef.^[2]^[3]

References

^ "Medscape.com". Retrieved 2008-12-29.
^ Yazawa K, Mikami Y, Uno J, Otozai K, Arai T (December 1989). "In-vitro activity of flomoxef, a new oxacephem group antibiotic, against Nocardia in comparison with other cephalosporins". J. Antimicrob. Chemother. 24 (6): 921–5. doi:10.1093/jac/24.6.921. PMID 2621177.
^ Cazzola M, Brancaccio V, De Giglio C, Paternò E, Matera MG, Rossi F (March 1993). "Flomoxef, a new oxacephem antibiotic, does not cause hemostatic defects". Int J Clin Pharmacol Ther Toxicol. 31 (3): 148–52. PMID 8468113.

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English Journal

Natural lipopeptide antibiotic tripropeptin C revitalizes and synergistically potentiates the activity of beta-lactams against methicillin-resistant Staphylococcus aureus.

Hashizume H1, Takahashi Y2, Harada S1, Nomoto A1.
The Journal of antibiotics.J Antibiot (Tokyo).2015 Jun;68(6):373-8. doi: 10.1038/ja.2014.169. Epub 2015 Jan 14.
Tripropeptin C (TPPC) is a natural calcium-ion-dependent lipopeptide antibiotic that inhibits peptidoglycan biosynthesis by binding to prenyl pyrophosphate. It displays very potent antimicrobial activity both in vitro and in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) septice
PMID 25586024

Structural basis for the role of Asp-120 in metallo-beta-lactamases.

Crisp J1, Conners R, Garrity JD, Carenbauer AL, Crowder MW, Spencer J.
Biochemistry.Biochemistry.2007 Sep 18;46(37):10664-74. Epub 2007 Aug 23.
Metallo-beta-lactamases (mbetals) are zinc-dependent enzymes that hydrolyze a wide range of beta-lactam antibiotics. The mbetal active site features an invariant Asp-120 that ligates one of the two metal ions (Zn2) and a metal-bridging water/hydroxide (Wat1). Previous studies show that substitutions
PMID 17715946

Expanded-spectrum beta-lactamase producing Klebsiella pneumoniae-related peritonitis in a patient on peritoneal dialysis.

Yang CC1, Chuang FR, Hsu KT, Chen JB, Lee CH, Lee CT, Chien YS, Chen TC, Cheng BC.
American journal of kidney diseases : the official journal of the National Kidney Foundation.Am J Kidney Dis.2004 Dec;44(6):e102-6.
While hospitalized for pneumonia with ventilator-dependent respiratory failure, a 45-year-old man on continuous ambulatory peritoneal dialysis (CAPD) had nosocomial peritonitis secondary to infection by expanded spectrum beta-lactamase producing Klebsiella pneumoniae (ESBL-Kp). He was treated succes
PMID 15558511

Japanese Journal

Safety Evaluation and Drug Development based on Biological Fate of Drugs —Efforts Made to Overcome Drug Interaction in Drug Development—

Drug Metabolism and Pharmacokinetics 17(5), 379-394, 2002
NAID 130004462854

1-Oxacephem-based human chymase inhibitors : Discovery of stable inhibitors in human plasma

Bioorg Med Chem Lett 10, 2403-2406, 2000
NAID 80012012723

整形外科領域におけるオキサセフェム系抗生物質の術後肝機能検査値異常に関する研究

The Japanese journal of antibiotics 52(7), 517-523, 1999-07-25
NAID 10005889920

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