関: jaagsiekte、ovine pulmonary adenomatosis

WordNet

any malignant tumor derived from epithelial tissue; one of the four major types of cancer
of or pertaining to or of the nature of or characteristic of a sheep or sheep

PrepTutorEJDIC

がん,がん腫
肺の;肺を冒す

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1. 肺癌の危険因子、病理、および臨床症状の概要 overview of the risk factors pathology and clinical manifestations of lung cancer
2. 肺癌が疑われる患者の初期評価、診断、および病期分類の概要 overview of the initial evaluation diagnosis and staging of patients with suspected lung cancer
3. 肺癌の初期評価、治療、および予後の概要 overview of the initial evaluation treatment and prognosis of lung cancer
4. 肺癌のスクリーニング screening for lung cancer
5. 原発性多発肺癌 multiple primary lung cancers

English Journal

Jaagsiekte sheep retrovirus detected in human lung cancer tissue arrays.

Linnerth-Petrik NM, Walsh SR, Bogner PN, Morrison C, Wootton SK1.Author information 1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada. kwootton@uoguelph.ca.AbstractBACKGROUND: Adenocarcinoma is the most common type of non-small cell lung cancer and is frequently observed in non-smoking patients. Adenocarcinoma in-situ (formerly referred to as bronchioloalveolar carcinoma) is a subset of lung adenocarcinoma characterized by growth along alveolar septae without evidence of stromal, vascular, or pleural invasion, that disproportionately affects never-smokers, women, and Asians. Adenocarcinoma in-situ is morphologically and histologically similar to a contagious lung neoplasm of sheep called ovine pulmonary adenocarcinoma (OPA). OPA is caused by infection with the exogenous betaretrovirus, jaagsiekte sheep retrovirus (JSRV), whose envelope protein (Env) is a potent oncogene. Several studies have reported that a proportion of human lung adenocarcinomas are immunopositive for an antigen related to the Gag protein of JSRV, however other groups have been unable to verify these observations by PCR.
BMC research notes.BMC Res Notes.2014 Mar 19;7:160. doi: 10.1186/1756-0500-7-160.
BACKGROUND: Adenocarcinoma is the most common type of non-small cell lung cancer and is frequently observed in non-smoking patients. Adenocarcinoma in-situ (formerly referred to as bronchioloalveolar carcinoma) is a subset of lung adenocarcinoma characterized by growth along alveolar septae without
PMID 24642139

Host species barriers to Jaagsiekte sheep retrovirus replication and carcinogenesis.

Caporale M1, Martineau H, De las Heras M, Murgia C, Huang R, Centorame P, Di Francesco G, Di Gialleonardo L, Spencer TE, Griffiths DJ, Palmarini M.Author information 1Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale, Teramo, Italy.AbstractUnderstanding the factors governing host species barriers to virus transmission has added significantly to our appreciation of virus pathogenesis. Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep that has rarely been found in goats. In this study, in order to further clarify the pathogenesis of OPA, we investigated whether goats are resistant to JSRV replication and carcinogenesis. We found that JSRV induces lung tumors in goats with macroscopic and histopathological features that dramatically differ from those in sheep. However, the origins of the tumor cells in the two species are identical. Interestingly, in experimentally infected lambs and goat kids, we revealed major differences in the number of virus-infected cells at early stages of infection. These differences were not related to the number of available target cells for virus infection and cell transformation or the presence of a host-specific immune response toward JSRV. Indeed, we also found that goats possess transcriptionally active endogenous retroviruses (enJSRVs) that likely influence the host immune response toward the exogenous JSRV. Overall, these results suggest that goat cells, or at least those cells targeted for viral carcinogenesis, are not permissive to virus replication but can be transformed by JSRV.
Journal of virology.J Virol.2013 Oct;87(19):10752-62. doi: 10.1128/JVI.01472-13. Epub 2013 Jul 31.
Understanding the factors governing host species barriers to virus transmission has added significantly to our appreciation of virus pathogenesis. Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep that has rarely b
PMID 23903827

Pathological and aetiological studies in sheep exhibiting extrathoracic metastasis of ovine pulmonary adenocarcinoma (Jaagsiekte).

Minguijón E1, González L, De las Heras M, Gómez N, García-Goti M, Juste RA, Moreno B.Author information 1Departamento de Sanidad Animal, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Derio, Vizcaya, Spain. eminguijon@neiker.netAbstractSeven sheep with a histopathological diagnosis of pulmonary adenocarcinoma with extrathoracic metastases were included in this retrospective study aiming to describe the pathological findings and to establish their relationship with Jaagsiekte sheep retrovirus (JSRV). In order of frequency, extrathoracic metastases were found in the liver, kidneys, skeletal muscle, digestive tract, spleen, skin and adrenal glands. Intrathoracic metastases involved the chest wall, regional lymph nodes, diaphragm and heart. Immunohistochemistry and polymerase chain reaction allowed detection of JSRV-related protein and nucleic acid, respectively, in the extrathoracic tumours of all cases. It is concluded that extrathoracic metastases constitute a pathological event of ovine pulmonary adenocarcinoma and confirm the malignant character of this virus-induced neoplasia.
Journal of comparative pathology.J Comp Pathol.2013 Feb;148(2-3):139-47. doi: 10.1016/j.jcpa.2012.06.003. Epub 2012 Aug 9.
Seven sheep with a histopathological diagnosis of pulmonary adenocarcinoma with extrathoracic metastases were included in this retrospective study aiming to describe the pathological findings and to establish their relationship with Jaagsiekte sheep retrovirus (JSRV). In order of frequency, extratho
PMID 22878053