The TLR4 gene polymorphisms and susceptibility to cancer: a systematic review and meta-analysis.
Zhang K, Zhou B, Wang Y, Rao L, Zhang L.SourceDepartment of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
European journal of cancer (Oxford, England : 1990).Eur J Cancer.2013 Mar;49(4):946-54. doi: 10.1016/j.ejca.2012.09.022. Epub 2012 Oct 17.
Growing studies revealed the association between polymorphisms in Toll-like receptor 4 (TLR4) and susceptibility to cancer, however, the results remained inconsistent. To assess the effect of six selected SNPs (rs1927914, rs4986790, rs4986791, rs11536889, rs1927911 and rs2149356) in TLR4 on cancer,
Antagonistic versus nonantagonistic models of balancing selection: characterizing the relative timescales and hitchhiking effects of partial selective sweeps.
Connallon T, Clark AG.SourceDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853-2703 E-mail: tmc233@cornell.edu.
Evolution; international journal of organic evolution.Evolution.2013 Mar;67(3):908-17. doi: 10.1111/j.1558-5646.2012.01800.x. Epub 2012 Sep 27.
Antagonistically selected alleles--those with opposing fitness effects between sexes, environments, or fitness components--represent an important component of additive genetic variance in fitness-related traits, with stably balanced polymorphisms often hypothesized to contribute to observed quantita
Association of BST-2 gene variants with HIV disease progression underscores the role of BST-2 in HIV type 1 infection.
Laplana M, Caruz A, Pineda JA, Puig T, Fibla J.SourceUnitat de Genètica Humana, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida and Institut de Recerca Biomèdica de Lleida, Lleida, Spain.
The Journal of infectious diseases.J Infect Dis.2013 Feb 1;207(3):411-9. doi: 10.1093/infdis/jis685. Epub 2012 Nov 12.
We tested bone marrow stromal cell antigen 2 (BST-2) gene variants rs3217318, a 19-base-pair insertion/deletion polymorphism in the promoter region, and rs10415893, a tag single-nucleotide polymorphism in the 3' untranslated region, for their association with human immunodeficiency virus type 1 (HI
Effect of population structure on the amount of polymorphism and the fixation probability under overdominant selection
Nishino Jo,Tajima Fumio
Genes & genetic systems 80(4), 287-295, 2005-08-25
… Under overdominant selection, mutants substantially contribute to increase the amount of polymorphism. … In this study, under overdominant selection the effect of population subdivision on the amount of polymorphism was investigated using the diffusion approximation and the low migration approximation. …
[section]) Genotypic odds ratios (ORs) are shown because these exceed allelic ORs for DDT (recessive model), bendiocarb, and fenitrothion (both overdominant models), and are similar for permethrin and deltamethrin. Multiple ...
over·dom·i·nance noun \ ˌ ō-vər-ˈ dä-mə-nən(t)s, - ˈ däm-nən(t)s\ Definition of OVERDOMINANCE: the condition wherein a heterozygote produces a phenotype more extreme or better adapted than that of the homozygote — over·dom·i ...